儿茶素及其衍生物抗病毒性肝炎的抗感染能力

StephenW

Clin Exp Vaccine Res. 2018 Jan;7(1):37-42. doi: 10.7774/cevr.2018.7.1.37. Epub  2018 Jan 29.
Anti-infective potential of catechins and their derivatives against viral hepatitis.Song JM1.
Author information
1Department of Global Medical Science, Health & Wellness College, Sungshin University, Seoul, Korea.

AbstractPolyphenols including catechins from green tea (Camellia sinensis) have been reported to have anti-infective activities against a broad spectrum of viruses and other pathogens. During the last two decades, antiviral activities of catechins with different modes of action have been demonstrated on diverse families of viruses, such as human immunodeficiency virus, Herpes simplex virus, influenza virus, hepatitis B and C virus. In this study, we focused on the antiviral properties of catechins and their derivatives against viral hepatitis which have become a key public health issue due to their serious impact on human health with liver diseases.


KEYWORDS: Antiviral agents; Catechin; Hepatitis

PMID:29399578PMCID:PMC5795043DOI:10.7774/cevr.2018.7.1.37

StephenW

临床实验疫苗研究2018年1月; 7（1）：37-42。 doi：10.7774 / cevr.2018.7.1.37。电子邮件2018年1月29日。
儿茶素及其衍生物抗病毒性肝炎的抗感染能力。
歌曲JM1。
作者信息

1
    韩国首尔崇信大学卫生与健康学院全球医学系。

抽象

据报道，包括来自绿茶（Camellia sinensis）的儿茶素的多酚对广谱病毒和其他病原体具有抗感染活性。在过去的二十年中，不同的病毒家族，如人类免疫缺陷病毒，单纯疱疹病毒，流感病毒，乙型肝炎病毒和丙型肝炎病毒，已经证实了具有不同作用方式的儿茶素的抗病毒活性。本研究以儿茶素及其衍生物对抗病毒性肝炎的抗病毒作用为研究重点，通过对肝病人类健康的严重影响，成为一个重要的公共卫生问题。
关键词：

抗病毒药物;儿茶素;肝炎

结论：
    29399578
PMCID：
    PMC5795043
DOI：
    10.7774 / cevr.2018.7.1.37

StephenW

Conclusion

Despite that vaccines and several anti-viral hepatitis drugs are available for patients with HBV and HCV, hepatotropic viral infection is still a severe public health problem in the world. In this review, many natural compounds especially polyphenol and their derivatives are already available with diverse biological activities (Table 1) and these offer a large opportunity for finding novel antiviral lead compounds or good candidates with unique anti-hepatitis viral drugs. Although there is an increasing amount of evidence that polyphenol compounds have anti-hepatitis viral effects to date, but they are limited to cell-based or animal-based studies. So it needs to be carefully assessed whether data from animal experiments are relevant to human, and future efforts should be devoted to optimize and develop for clinical application. When some of these compounds become clinically available, a new path for chemoprevention of hepatotropic viral infection will be opened and control of liver diseases could be dramatically improved.

结论

尽管乙型肝炎病毒和丙型肝炎病毒已经有了疫苗和几种抗病毒药物，但肝炎病毒感染仍然是世界上严重的公共卫生问题。在这篇综述中，许多天然化合物，尤其是多酚及其衍生物已经具有多种生物学活性（表1），为寻找具有独特抗肝炎病毒药物的新型抗病毒先导化合物或良好候选物提供了大量机会。虽然越来越多的证据表明多酚类化合物迄今为止具有抗肝炎病毒作用，但是它们仅限于基于细胞或基于动物的研究。因此，需要认真评估动物实验的数据是否与人类相关，今后应该致力于临床应用的优化和发展。当这些化合物中的一些成为临床可用时，化学预防肝病毒感染的新途径将被打开，并且可以显着改善对肝病的控制。

StephenW

https://synapse.koreamed.org/DOI ... cevr.2018.7.1.37#T1

Hepbest

继咖啡之后，看来喝绿茶对抗病毒也有好处啊