儿童慢性乙型肝炎病毒感染的肝纤维化临床预测因子

StephenW

J Infect Dis. 2018 Jan 30. doi: 10.1093/infdis/jiy048. [Epub ahead of print]
Clinical predictors of liver fibrosis in patients with chronic hepatitis B virus infection from children to adults.Wu JF1, Song SH2,3, Lee CS4, Chen HL1,5, Ni YH1,5, Hsu HY1, Wu TC2,3, Chang MH1,5.
Author information
1Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.2National Yang Ming University School of Medicine, Taiwan.3Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan.4Department of Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan.5Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan.

AbstractBackground: This study aimed to elucidate predictors of liver fibrosis in chronic hepatitis B virus (HBV)-infected subjects.
Methods: Transient elastography was performed to define liver fibrosis in 533 chronic HBV-infected patients at 30.72 ± 0.57 years of age. Protein array was performed on serum samples and lysates of Huh7 cells transfected with HBV mutants; the results were confirmed by ELISA. Single nucleotide polymorphisms in the interleukin-1β gene were examined chronic HBV-infected patients with and without liver fibrosis.
Results: Male gender, > 18 years old, and serum alpha-fetoprotein level > 3.6 ng/mL were independent predictors of a liver stiffness measurement of ≥ 7 kPa (P = 0.005, 0.019, and < 0.001, respectively). HBeAg-negative hepatitis is associated with increased liver stiffness (P<0.001). Elevation of serum interleukin-1β was demonstrated in subjects with liver fibrosis. Interleukin-1β was upregulated in Huh7 cells transfected with HBeAg-negative hepatitis-related mutants. The AA genotype at rs16944 and the CC genotype at rs1143627 of the interleukin-1β gene were associated with higher serum interleukin-1β levels and liver fibrosis.
Conclusions: Male gender, beyond childhood, elevated alpha-fetoprotein level, and HBeAg-negative hepatitis are risk factors for liver fibrosis. Interleukin-1β is involved in the progression of liver fibrosis in subjects with HBeAg-negative hepatitis.


KEYWORDS: Cytokines; Hepatitis B virus e antigen; Interleukin-1β; Liver fibrosis; Seroconversion

PMID:29390144DOI:10.1093/infdis/jiy048

StephenW

J传染病2018年1月30日doi：10.1093 / infdis / jiy048。 [电子版提前打印]
儿童慢性乙型肝炎病毒感染的肝纤维化临床预测因子。
吴茉1，宋2 2,3，李CS4，陈HL1,5，倪YH1,5，徐HY1，吴TC2,3，张MH1,5。
作者信息

1
    台湾台北大学医学院儿科。
2
    国立杨明大学医学院，台湾。
3
    台北慈济医学基金会台北慈济医院小儿科
4
    台湾台北大学医院肝炎研究中心台湾台北。
五
    台湾台北退伍军人医院儿科台湾台北

抽象
背景：

本研究旨在阐明慢性乙型肝炎病毒（HBV）感染受试者肝纤维化的预测因子。
方法：

在30.72±0.57岁年龄段的533例慢性HBV感染患者中进行瞬态弹性成像以定义肝纤维化。蛋白质阵列在用HBV突变体转染的Huh7细胞的血清样品和裂解物上进行;结果通过ELISA确认。对白介素-1β基因的单核苷酸多态性进行了检查，慢性HBV感染患者肝纤维化和无肝纤维化。
结果：

男性> 18岁，血清甲胎蛋白水平> 3.6 ng / mL是≥7 kPa肝硬度测量的独立预测因子（分别为P = 0.005,0.019和<0.001）。 HBeAg阴性肝炎与肝硬度增加有关（P <0.001）。在患有肝纤维化的受试者中证实了血清白细胞介素-1β的升高。白细胞介素-1β在转染HBeAg阴性肝炎相关突变体的Huh7细胞中上调。白细胞介素-1β基因rs16944处的AA基因型和rs1143627处的CC基因型与血清白细胞介素-1β水平升高和肝纤维化有关。
结论：

男性性别超过儿童，甲胎蛋白水平升高和HBeAg阴性肝炎是肝纤维化的危险因素。白细胞介素-1β参与了HBeAg阴性肝炎患者肝纤维化的进展。
关键词：

细胞因子;乙型肝炎病毒e抗原;白细胞介素1β;肝纤维化;血清转化

结论：
    29390144
DOI：
    10.1093 / infdis / jiy048

jdcy

虽然翻译了、再帮忙简化一下、有些专业术语理解不了！

StephenW

回复 jdcy 的帖子

这实际上是台湾一个非常好的临床研究.

533名患者随访13岁至约30岁.
男性, 年龄 > 17，甲胎蛋白水平> 3.6 ng / mL和 HBeAg
HBeAg血清转换后阴性肝炎是肝纤维化 > 7 kpa 的因素。

jdcy

StephenW 发表于 2018-2-3 19:19
回复 jdcy 的帖子

这实际上是台湾一个非常好的临床研究.

最后一句还是不明白！

StephenW

回复 jdcy 的帖子

HBeAg血清转换后阴性肝炎  - 小三肝炎. 旧的术语是 Immune Escape, 免疫逃逸期.

jdcy

StephenW 发表于 2018-2-4 11:27
回复 jdcy 的帖子

HBeAg血清转换后阴性肝炎  - 小三肝炎. 旧的术语是 Immune Escape, 免疫逃逸期.  ...

这下明白了、谢谢！