本帖最后由 StephenW 于 2018-1-31 18:41 编辑
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Comparison of clinical and virological features among hepatitis B virus genotypes
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Genotype
| B | C | A | D | E-J | Clinical characteristics | Modes of transmission | Perinatal/vertical | Perinatal/vertical | Horizontal | Horizontal | Horizontal | Tendency of chronicity | Lower | Higher | Higher | Lower | ND | Positivity of HBeAg | Lower | Higher | Higher | Lower | ND | HBeAg Seroconversion | Earlier | Later | Earlier | Later | ND | HBsAg seroclearance | More | Less | More | Less | ND | Histological activity | Lower | Higher | Lower | Higher | ND | Clinical outcomes (LC, HCC) | Better | Worse | Better | Worse | Worse in genotype F | Response to INF-α | Higher | Lower | Higher | Lower | Lower in genotype G | Response to nucleos(t)ide analogs | No significant differences among genotypes A to D | ND | Virological characteristics | Serum HBV DNA level | Lower | Higher | ND | ND | ND | Frequency of PC A1896 mutation | Higher | Lower | Lower | Higher | ND | Frequency of basal core promoterT1762/A1764 mutation | Lower | Higher | Higher | Lower | ND | Frequency of preS deletion mutation | Lower | Higher | ND | ND | ND |
ND: No data available; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma; HBV: Hepatitis B virus.
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