未治疗的慢性乙型肝炎患者血清维生素D水平。

StephenW

J Transl Int Med. 2017 Dec 29;5(4):230-234. doi: 10.1515/jtim-2017-0038. eCollection  2017 Dec.
Serum Vitamin D Levels in Treatment-naïve Chronic Hepatitis B Patients.Said E1, Agawy WE2, Ahmed R2, Hassany M2, Ahmed A3, Fouad H4, Baiumy H1.
Author information

AbstractBackground and Objectives: According to the demographic health survey conducted in 2015, Egypt had 10% documented prevalence of anti-HBc positive patients aged 1-59 and 1% viremic patients amongst the population in the same age group, with a domination of genotype D. Several studies claimed the possible role of vitamin D deficiency in hepatitis B virus (HBV) replication and disease progression.
Patients and Methods: Serum vitamin D levels [25(OH D3] were assessed in 96 HBeAg negative non-cirrhotic chronic HBV patients and 25 healthy subjects classified as following: Group I: 48 chronic HBV patients with persistently normal ALT levels and HBV DNA level < 2000 IU/mL for ≥ 6 months; Group II: 48 chronic HBV patients with CHB with persistently elevated ALT and HBV DNA level ≥ 2000 IU/mL for ≥ 6 months; and Group III: 25 apparently healthy subjects with normal liver enzymes and negative hepatitis viral markers were taken as the control group.
Results: Vitamin D was much more deficient in group II than in group I and group III being 11.55 ± 3.97 ng/mL, 15.03 ± 3.45, 27.00 ± 6.76 ng/mL (P < 0.001), respectively, and a strong negative correlation was observed between vitamin D levels and HBV DNA levels (P = 0.043) in groups I and II.
Conclusion: The current study showed high HBV DNA replication in patients with vitamin D deficiency suggesting the antimicrobial immunomodulatory role of vitamin D.


KEYWORDS: Egyptian; hepatitis B virus; vitamin D

PMID:29340280PMCID:PMC5767713DOI:10.1515/jtim-2017-0038

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StephenW

J Transl Int Med。 2017年12月29日; 5（4）：230-234。 doi：10.1515 / jtim-2017-0038。 eCollection 2017年12月
未治疗的慢性乙型肝炎患者血清维生素D水平。
说E1，Agawy WE2，Ahmed R2，Hassany M2，Ahmed A3，Fouad H4，Baiumy H1。
作者信息
抽象
背景和目标：

根据2015年进行的人口健康调查，埃及在同一年龄组人口中报告了抗-HBc阳性患者1-59岁和1％病毒血症患者的10％的流行率，并且控制了基因型D.一些研究声称维生素D缺乏在乙型肝炎病毒（HBV）复制和疾病进展中的可能作用。
患者和方法：

在96名HBeAg阴性非肝硬化慢性HBV患者和25名健康受试者中评估了血清维生素D水平[25（OH D3），分类如下：组I：48名ALT持续正常且HBV DNA水平<2000IU / mL，持续≥6个月;Ⅱ组：48例慢性乙型肝炎患者，ALT持续升高，HBVDNA≥2000IU/mL≥6个月;Ⅲ组：25例肝酶正常，肝炎病毒标志物阴性的健康人作为对照组。
结果：

维生素D缺乏组比第一组和第三组分别为11.55±3.97ng / mL，15.03±3.45,27.00±6.76ng / mL（P <0.001），两者之间呈显着负相关维生素D水平和HBV DNA水平（P = 0.043）在第一组和第二组。
结论：

目前的研究显示，维生素D缺乏患者HBV DNA高复制提示维生素D具有抗微生物免疫调节作用。
关键词：

埃及人;乙肝病毒;维生素D

结论：
    29340280
PMCID：
    PMC5767713
DOI：
    10.1515 / jtim-2017-0038

Hepbest

维生素D缺乏患者HBV DNA高复制，提示维生素D具有抗微生物免疫调节作用。