不同AFP水平的原发性肝癌患者血清GGT水平及GGT / ALT和AST / ALT

StephenW

Cancer Biomark. 2017 Dec 22. doi: 10.3233/CBM-170088. [Epub ahead of print]
Rule of changes in serum GGT levels and GGT/ALT and AST/ALT ratios in primary hepatic carcinoma patients with different AFP levels.Yang JG, He XF, Huang B, Zhang HA, He YK.
AbstractOBJECTIVE: This study aims to explore the rule of changes in serum GGT activity, as well as GGT/ALT and AST/ALT ratios, in primary hepatic carcinoma (PHC) patients with different alpha-fetal protein (AFP) levels.
METHODS: GGT, AST and ALT were detected in 370 PHC patients with positive HBs-Ag using a automatic biochemical analyzer, and AFP was detected using a Roche E170 modular analytics immunoassay analyzer. GGT level, as well as AST/ALT and GGT/ALT, ratios were compared among PHC patients with different AFP levels.
RESULTS: As shown in Table 1, GGT levels were 109.59 ± 111.06, 151.13 ± 190.43, 135.86 ± 107.62, 151.36 ± 176.59 and 172.58 ± 188.84, respectively, in the groups of primary PHC patients with AFP levels of ⩽ 10, 10-100, 100-200, 200-400 and ⩾ 400 ng/ml; and the differences among these groups were not statistically significant (P> 0.05). AST/ALT ratios were 1.55 ± 1.02, 1.30 ± 0.81, 2.02 ± 1.89, 2.12 ± 1.11 and 1.73 ± 1.25, respectively; and the differences among these groups were not statistically significant (P> 0.05). GGT/ALT ratios were 3.43 ± 3.12, 3.57 ± 5.70, 3.57 ± 2.94, 3.89 ± 4.58 and 3.43 ± 3.61, respectively; and the differences among these groups were not statistically significant (P> 0.05).
CONCLUSION: For patients with chronic hepatitis B and cirrhosis after hepatitis B, no matter how AFP level is, when liver function report reveals increased GGT, AST/ALT > 1 and GGT/ALT > 1 (that is, AST > ALT and GGT > ALT), even if AFP is negative, we should also be alert to the existence of PHC.


KEYWORDS: GGT; Liver neoplasms; hepatitis B; liver cirrhosis

PMID:29286913DOI:10.3233/CBM-170088

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StephenW

癌症生物标志。 2017 Dec 22。doi：10.3233 / CBM-170088。 [电子版提前打印]
不同AFP水平的原发性肝癌患者血清GGT水平及GGT / ALT和AST / ALT比值的变化规律。
杨建国何晓峰黄斌张海何K
抽象
目的：

本研究旨在探讨不同α-胎儿蛋白（AFP）水平的原发性肝癌（PHC）患者血清GGT活性以及GGT / ALT和AST / ALT比值的变化规律。
方法：

采用全自动生化分析仪检测370例HBsAg阴性的PHC患者GGT，AST和ALT，采用Roche E170模块化分析免疫分析仪检测AFP。比较不同AFP水平的PHC患者GGT水平，以及AST / ALT和GGT / ALT比值。
结果：

如表1所示，在AFP水平≥10,10-100,100的原发性PHC患者组中，GGT水平分别为109.59±111.06,151.13±190.43,135.86±107.62,151.36±176.59和172.58±188.84 -200,200-400和≥400ng/ ml;差异无统计学意义（P> 0.05）。 AST / ALT比值分别为1.55±1.02,1.30±0.81,2.02±1.89,2.12±1.11和1.73±1.25;差异无统计学意义（P> 0.05）。 GGT / ALT比值分别为3.43±3.12,3.57±5.70,3.57±2.94,3.89±4.58和3.43±3.61;差异无统计学意义（P> 0.05）。
结论：

对于乙型肝炎后慢性乙型肝炎和肝硬化患者，无论AFP水平如何，当肝功能报告显示GGT增加时，AST / ALT> 1和GGT / ALT> 1（即AST> ALT和GGT> ALT）即使法新社是负面的，我们也应该警惕PHC的存在。
关键词：

GGT;肝肿瘤;乙肝;肝硬化

结论：
    29286913
DOI：
    10.3233 / CBM-170088