慢性HBV感染患者血清IL-6，IL-8，TNF-α和TGF-β的水平：抑郁和

StephenW

Lab Med. 2017 Dec 11. doi: 10.1093/labmed/lmx064. [Epub ahead of print]
Serum Levels of IL-6, IL-8, TNF-α, and TGF-β in Chronic HBV-Infected Patients: Effect of Depression and Anxiety.Bahramabadi R1,2, Fathollahi MS1,3, Hashemi SM4, Arababadi AS1, Arababadi MS1, Yousefi-Daredor H1, Bidaki R5,6, Khaleghinia M7, Bakhshi MH1, Yousefpoor Y4, Torbaghan YE4, Arababadi MK1,2.
Author information
1Immunology of Infectious Diseases Research Center.2Department of Immunology, Faculty of Medicine.3Department of Epidemiology and Biostatistics, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.4Khalil Abad Health Center, Mashhad University of Medical Sciences, Mashhad, Iran.5Research Center of Addiction and Behavioral Sciences.6Diabetes Research Center, Shahid Sadoughi University of Medical Science, Yazd, Iran.7Department of Infectious Diseases, Medical School, Kerman University of Medical Sciences, Kerman, Iran.

AbstractObjective: To assess the effects of depression and anxiety on serum cytokine levels in patients with chronic hepatitis B (CHB) infection.
Methods: In this cross-sectional study, 60 healthy control individuals and 60 patients with CHB participated after filling out standard questionnaires. We examined their serum interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, and TGF-β levels using enzyme-linked immunosorbent assay (ELISA) techniques.
Results: In patients with CHB compared with healthy controls, serum levels of IL-8 were significantly increased, whereas IL-6 and TGF-β levels were significantly decreased. Serum levels of TGF-β were significantly decreased in the patients with CHB who had mild depression, compared with patients with CHB without depression and with moderate and severe depression.
Conclusions: Downregulation of IL-8 and TGF-β, respectively, is a corresponding mechanism for induction of chronic inflammation in patients with CHB. Depression also seems to induce inflammation via downregulation of TGF-β in these patients.


KEYWORDS: IL-6; IL-8; TGF-β; TNF-α; chronic HBV infection; psychiatric diseases

PMID:29237050DOI:10.1093/labmed/lmx064

StephenW

Lab Med。 2017年12月11日doi：10.1093 / labmed / lmx064。 [电子版提前打印]
慢性HBV感染患者血清IL-6，IL-8，TNF-α和TGF-β的水平：抑郁和焦虑的影响。
Bahramabadi R1,2，Fathollahi MS1,3，Hashemi SM4，Arababadi AS1，Arababadi MS1，Yousefi-Daredor H1，Bidaki R5,6，Khaleghinia M7，Bakhshi MH1，Yousefpoor Y4，Torbag​​han YE4，Arababadi MK1,2。
作者信息

1
    传染病研究中心免疫学。
2
    医学系免疫学系。
3
    伊朗拉夫桑詹医学院拉夫桑詹医科大学流行病学和生物统计学系。
4
    伊朗马什哈德Mashhad医学大学Khalil Abad健康中心。
五
    成瘾与行为科学研究中心。
6
    糖尿病研究中心，Shahid Sadoughi医学大学，亚兹德，伊朗。
7
    克尔曼医科大学医学院传染病系，伊朗克尔曼。

抽象
目的：

评估抑郁和焦虑对慢性乙型肝炎（CHB）感染患者血清细胞因子水平的影响。
方法：

在这项横断面研究中，60名健康对照者和60名CHB患者在填写标准问卷后参加。我们用酶联免疫吸附试验（ELISA）技术检测了他们的血清白细胞介素（IL）-6，IL-8，肿瘤坏死因子（TNF）-α和TGF-β水平。
结果：

慢性乙型肝炎患者与正常对照组相比，血清IL-8水平明显升高，而IL-6和TGF-β水平明显下降。 CHB轻度抑郁患者血清TGF-β水平明显下降，与CHB无抑郁，中重度抑郁患者相比，差异有统计学意义。
结论：

IL-8和TGF-β的下调分别是慢性乙型肝炎患者慢性炎症诱导的相应机制。抑郁症似乎也可以通过下调TGF-β诱导炎症反应。
关键词：

IL-6; IL-8; TGF-β; TNF-α;慢性HBV感染;精神疾病

结论：
    29237050
DOI：
    10.1093 / labmed / lmx064