十氯酮对活性慢性肝炎的影响

StephenW

Impact of Chlordecone on Active Chronic Hepatitis
Primary Outcome Measures:

    Evaluation of progression to cirrhosis with a correlation test between chlordecone exposure and fibrosis in active and chronic hepatitis due to virus B, C or alcohol. [ Time Frame: through study completion, an average of 5 years. ]

    : Chlordecone level will be compared among the two groups (patients with or without significant fibrosis) in order to determine the impact of chlordecone on the evolution of fibrosis. Patients of each group will be paired according to the age, sex, origin of the liver disease. Analysis will be performed using SPSS software.

Secondary Outcome Measures:

Actually, there is no data concerning the impact of chlordecone on the evolution of fibrosis to cirrhosis in chronic hepatitis whereas many studies have been reported liver damage in mice. The goal of this study is to know if co-exposition to chlordecone can induce evolution to cirrhosis in chronic hepatitis due to alcohol or viral hepatitis. At first, we will assess a group of patients with chronic hepatitis B, C or due to alcohol without fibrosis. And they will be compared to patients with cirrhosis exposed to chlordecone too. Patients will be included in 2 hospital centers. All these patients should have an active liver disease. The activity will be defined by histology or elevated transaminases (>2N), fibrosis will be defined by histology or an association of fibroscan and biological markers. Exposition to chlordecone will be evaluated by a blood chlordecone measure for every patient.

Source: imported from this press release.

StephenW

十氯酮对活性慢性肝炎的影响
主要结果措施：

    用病毒B，C或酒精对活性和慢性肝炎的十氯酮暴露和纤维化进行相关性检验评估进展为肝硬化。 [时限：通过学习完成，平均5年。 ]

    ：为了确定十氯酮对纤维化进程的影响，将比较两组（十二指肠和十二指肠组织）十氯酮水平。每组病人将根据年龄，性别，肝病的起源进行配对。将使用SPSS软件进行分析。

次要结果措施：

实际上，没有关于十氯酮对慢性肝炎中纤维化进展为肝硬化的影响的数据，而许多研究报道了小鼠的肝损伤。这项研究的目的是要知道，如果与酒精或病毒性肝炎共同作用于十氯酮，可以诱发慢性肝炎进展为肝硬化。首先，我们将评估一组慢性乙型肝炎，丙型肝炎或酒精无纤维化的患者。他们也将与肝硬化暴露于十氯酮的患者进行比较。患者将被纳入2个医院中心。所有这些患者都应该有活跃的肝脏疾病。活性将由组织学或升高的转氨酶（> 2N）定义，纤维化将通过组织学或纤维扫描与生物学标志物的关联来定义。对十氯酮的评估将通过每名患者的十氯酮血液评估进行评估。

来源：从这个新闻稿中导入。