慢性乙型肝炎自然史期间血清乙型肝炎核心相关抗原的不同

StephenW

BMC Gastroenterol. 2017 Dec 4;17(1):140. doi: 10.1186/s12876-017-0703-9.
Distinct patterns of serum hepatitis B core-related antigen during the natural history of chronic hepatitis B.
Zhang ZQ1, Zhang XN2, Lu W3, Wang YB3, Weng QC4, Feng YL5.
Author information

1
    Department of Hepatology, Shanghai Public Health Clinical Center, Fudan University, Caolang Road 2901, Shanghai, 201508, China. [email protected].
2
    Research Unit, Shanghai Public Health Clinical Center, Fudan University, Caolang Road 2901, Shanghai, 201508, China. [email protected].
3
    Department of Hepatology, Shanghai Public Health Clinical Center, Fudan University, Caolang Road 2901, Shanghai, 201508, China.
4
    Shanghai Representative Office, Fujirebio Inc., Shanghai, China.
5
    Department of Clinical Pathology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Abstract
BACKGROUND:

The current clinical practice on chronic hepatitis B (CHB) requires better on-treatment monitoring of viral persistence. Quantified assays for hepatitis B surface antigen (HBsAg) and core-related antigen (HBcrAg) hold promise for further optimization of therapy. Here, we aimed to characterize HBcrAg during the natural course of CHB.
METHODS:

Four-hundred and forty four treatment naïve CHB patients, who all underwent liver histology examination, were enrolled in this cross-sectional study. Their HBV DNA, HBsAg, HBeAg and HBcrAg titres were quantified and analyzed in the context of four distinct clinical phases. Correlation of HBcrAg and HBsAg with other markers were performed. The relationship between liver and serum antigen levels were also assessed.
RESULTS:

HBcrAg, like HBsAg, exhibited high degree of correlation with HBV DNA. However, a more significant linear relationship was found between HBcrAg and HBeAg titre in immune tolerant (IT) and immune clearance (IC) phases, while in HBeAg negative hepatitis (ENH) group, HBV DNA is a major determinant of HBcrAg. Significant difference was observed in liver HBcAg score and HBcrAg level in both IT and IC phases whereas barely significant positive correlations between liver HBsAg score and HBsAg titre was documented.
CONCLUSION:

HBcrAg titre exhibited distinct correlative profile in a phase-specific manner. In addition, its level is well-related to the intrahepatic expression of core antigen. It has a considerable utility in monitoring and refining antiviral therapy.
KEYWORDS:

HBV; HBcrAg; HBsAg

PMID:
    29202690
DOI:
    10.1186/s12876-017-0703-9

StephenW

BMC Gastroenterol。 2017年12月4日; 17（1）：140. Doi：10.1186 / s12876-017-0703-9。
慢性乙型肝炎自然史期间血清乙型肝炎核心相关抗原的不同模式
张梓1 1，张新民2，卢炜W3，王晔3，翁QC4，冯烨5
作者信息

1
上海市复旦大学上海公共卫生临床中心上海市曹朗路2901号邮编：201508 [email protected]。
2
上海市复旦大学上海市公共卫生临床中心研究组上海市曹Road路2901号邮编：201508 [email protected]。
3
上海市复旦大学上海公共卫生临床中心上海市曹朗路2901号邮编：201508
4
中国上海Fujirebio公司上海代表处
五
上海复旦大学上海市公共卫生临床中心临床病理科。

抽象
背景：

目前对慢性乙型肝炎（CHB）的临床实践要求更好地对病毒持续性进行治疗监测。乙型肝炎表面抗原（HBsAg）和核心相关抗原（HBcrAg）的定量测​​定有希望进一步优化治疗。在这里，我们的目标是在CHB的自然过程中表征HBcrAg。
方法：

444名接受过肝脏组织学检查的初治慢性乙型肝炎患者参加了这项横断面研究。他们的HBV DNA，HBsAg，HBeAg和HBcrAg滴度定量和分析在四个不同的临床阶段的背景下。 HBcrAg和HBsAg与其他标记物的相关性被执行。还评估了肝脏和血清抗原水平之间的关系。
结果：

HBcrAg与HBV DNA高度相关。然而，HBV DNA之间有更显着的线性关系。然而，HBV DNA之间有更显着的线性关系。然而，HBV与HBeAg阴性肝炎（ENH）组之间存在更显着的线性关系，HBV DNA是HBcAgAg的主要决定因素。肝内HBcAg评分和HBcrAg水平在IT和肝内HBsAg评分与HBsAg滴注之间几乎呈正相关。
结论：

HB在监测和提炼抗病毒治疗方面具有显着的效用。另外，其水平与核心抗原的肝内表达密切相关。
关键词：

HBV; HBcrAg;乙肝表面抗原

结论：
29202690
DOI：
10.1186 / s12876-017-0703-9