肝细胞癌及其可能的化学和生物学原因：综述

StephenW

J Environ Pathol Toxicol Oncol. 2017;36(2):171-190. doi: 10.1615/JEnvironPatholToxicolOncol.2017020927.
Hepatocellular Carcinoma and Possible Chemical and Biological Causes: A Review.Erkekoglu P1, Oral D1, Chao MW2, Kocer-Gumusel B3.
Author information
1Hacettepe University, Faculty of Pharmacy, Department of Toxicology, 06100 Ankara Turkey.2Chung Yuan Christian University, Department of Bioscience Technology, Zhongli district, Taoyuan, Taiwan.3Hacettepe University, Faculty of Pharmacy, Department of Toxicology, 06100 Ankara, Turkey.

AbstractThe development of hepatocellular carcinoma (HCC) is a multistep process. In HCC, progressive and morphologically distinct preneoplastic lesions/alterations associated with chronic liver injury, inflammation, hepatocellular degeneration/regeneration, necrosis, and small-cell dysplasia can be observed. The incidence of HCC exhibits regional and ethnic differences. Several cytotoxic and DNA-damaging chemicals are suggested to be the underlying causes of HCC-for example, acrylamide, perfluorooctanoic acid (PFOA), polychlorinated biphenyls (PCBs), benzo(a)pyrene (BaP), perfluorinated chemicals (PFCs), vinyl chloride monomer (VCM), and dietary contaminants (aflatoxins, ochratoxins). Also suggested are substances of abuse (alcohol) and biological agents, such as hepatitis B and C and human immunodeficiency virus 1 (HIV-1). These can act through genetic and/or epigenetic mechanisms. This review will shortly address the genetic and epigenetic mechanisms of HCC and focus on cytotoxic and DNA-damaging chemicals and biological agents, exposure to which are suggested to lead to HCC initiation, promotion, and/or progression.


PMID:29199597DOI:10.1615/JEnvironPatholToxicolOncol.2017020927

StephenW

J Environ Pathol Toxicol Oncol。 2017; 36（2）：171-190。 doi：10.1615 / JEnvironPatholToxicolOncol.2017020927。
肝细胞癌及其可能的化学和生物学原因：综述。
Erkekoglu P1，Oral D1，Chao MW2，Kocer-Gumusel B3。
作者信息

1
    Hacettepe大学药剂学系，毒理学系，土耳其安卡拉06100。
2
    中原大学中原区生物科学技术中心。
3
    Hacettepe大学药剂系，毒理学系，06100安卡拉，土耳其。

抽象

肝细胞癌（HCC）的发展是一个多步骤的过程。在HCC中，可观察到与慢性肝损伤，炎症，肝细胞变性/再生，坏死和小细胞发育异常有关的进行性和形态学上不同的癌前病变/改变。 HCC的发病率呈现地区和种族差异。一些细胞毒性和DNA损伤的化学物质被认为是HCC的潜在原因，例如丙烯酰胺，全氟辛酸（PFOA），多氯联苯（PCBs），苯并（a）芘（BaP），全氟化合物（PFCs），乙烯基氯化物单体（VCM）和膳食污染物（黄曲霉毒素，赭曲霉毒素）。还建议滥用（乙醇）物质和生物制剂，如乙型肝炎和丙型肝炎和人类免疫缺陷病毒1（HIV-1）。这些可以通过遗传和/或表观遗传机制起作用。本综述将简要介绍HCC的遗传和表观遗传机制，并着重介绍细胞毒性和DNA损伤的化学物质和生物制剂，建议接触这些化学制剂和生物制剂以导致HCC的发生，促进和/或进展。

结论：
    29199597
DOI：
    10.1615 / JEnvironPatholToxicolOncol.2017020927