NAFLD / NASH的自然史

StephenW

Natural History of NAFLD/NASH

• Authors
• Authors and affiliations
  

• Mattias EkstedtEmail author
• Patrik Nasr
• Stergios Kechagias
  

• Mattias Ekstedt
  • 1
    
  Email author
• Patrik Nasr
  • 1
    
• Stergios Kechagias
  • 1
    
  
  

• 1.Department of Gastroenterology and Hepatology, Department of Medical and Health SciencesLinköping UniversityLinköpingSweden
  

Open Access
Fatty Liver Disease (S Harrison and J George, Section Editors)First Online: 13 November 2017


            

•                          103                         Downloads
  

   

Part of the following topical collections:

• Topical Collection on Fatty Liver Disease
  

AbstractPurpose of Review

The purpose of this review is to summarize the latest knowledge on the natural history of non-alcoholic fatty liver disease (NAFLD). The review focuses on mortality, liver-related complications, and histological course.

Recent Findings

Studies during the last decade have established NAFLD as a potentially progressive liver disease. Age and diabetes are the strongest clinical predictors of progressive disease. Fibrosis stage is the most important histological variable to predict mortality and liver-related complications. So far, no study has been able to show that non-alcoholic steatohepatitis at baseline predicts mortality or future liver-related complications when adjusting for fibrosis.

Summary

The outlines of the natural history of NAFLD have become clearer during the last decade. There is limited data on factors that predict clinical progression. Prospective longitudinal studies are needed to help us predict worse outcome in individual patients.

KeywordsNatural history Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Prognosis Mortality Liver histology

This article is part of the Topical Collection on Fatty Liver Disease

StephenW

NAFLD / NASH的自然史

    作者
    作者和从属关系

    Mattias EkstedtEmail作者帕特里克NasrStergios Kechagias

    Mattias Ekstedt
        1电子邮件作者
    Patrik Nasr
        1
    Stergios Kechagias
        1

    1.医学与卫生学院消化病与肝病研究所，北京大学连锁学院

开放存取
脂肪肝疾病（S Harrison和J George，科室编辑）
首次在线：2017年11月13日

    103下载

以下专题集合的一部分：

    脂肪肝疾病的典型收藏

抽象
审查的目的

本综述的目的是总结有关非酒精性脂肪性肝病（NAFLD）自然史的最新知识。综述主要集中在死亡率，肝脏相关并发症和组织学过程。
最近的发现

过去十年的研究已经将NAFLD确立为潜在的进行性肝病。年龄和糖尿病是进行性疾病的最强临床预测指标。纤维化阶段是预测死亡率和肝相关并发症的最重要的组织学变量。到目前为止，还没有研究能够显示基线时的非酒精性脂肪性肝炎预测死亡率或调整纤维化后的肝脏相关并发症。
概要

在过去的十年中，NAFLD自然史的轮廓变得更加清晰。关于预测临床进展的因素数据有限。需要前瞻性纵向研究来帮助我们预测个别患者的恶化结果。
关键词
自然史非酒精性脂肪肝疾病非酒精性脂肪性肝炎预后死亡率肝脏组织学

这篇文章是脂肪肝疾病的专题收藏的一部分

StephenW

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