影像学评估NAFLD脂肪变性，炎症和纤维化

StephenW

Imaging-Based Assessment of Steatosis, Inflammation and Fibrosis in NAFLD

• Authors
• Authors and affiliations
  

• Timothy Hardy
• Stuart McPhersonEmail author
  

• Timothy Hardy
  • 1
  • 2
    
• Stuart McPherson
  • 2
  • 3
    
  Email author
  

• 1.GastroenterologyNorth Tees University HospitalStocktonUK
• 2.Institute of Cellular Medicine, Faculty of Medical SciencesNewcastle UniversityNewcastle Upon TyneUK
• 3.Liver UnitNewcastle Upon Tyne Hospitals NHS Trust, Freeman HospitalNewcastle Upon TyneUK
  

Open Access
Fatty Liver Disease (S Harrison and J George, Section Editors)First Online: 16 November 2017


            

•                          59                         Downloads
  

   

Part of the following topical collections:

• Topical Collection on Fatty Liver Disease
  

AbstractPurpose of Review

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the Western world. Invasive liver biopsy remains the gold standard method for the diagnosis and staging of NAFLD. The aim of this review is to summarize recent research regarding imaging-based assessment of NAFLD.

Recent Findings

Novel methods such as controlled attenuation parameter (CAP) and magnetic resonance imaging proton-derived fat fraction (MRI-PDFF) appear promising for steatosis assessment and are currently undergoing validation in NAFLD. Fibrosis can be non-invasively assessed by transient elastography (TE), which is currently the best validated test in NAFLD. MR elastography (MRE) appears very sensitive for fibrosis detection. No imaging technique can accurately detect NASH.

Summary

TE is inexpensive and relatively widely available and can reliably exclude advanced fibrosis in NAFLD. MRI offers the most promise for steatosis and fibrosis quantification, but further validation of these techniques is needed.

KeywordsNAFLD Steatosis Fibrosis Magnetic resonance imaging Transient elastography Imaging Non-invasive test Ultrasound

StephenW

影像学评估NAFLD脂肪变性，炎症和纤维化

    作者
    作者和从属关系

    Timothy HardyStuart McPhersonEmail作者

    蒂莫西·哈代
        12
    Stuart McPherson
        23电子邮件作者

    1.Gastroenterology北蒂斯大学医院StocktonUK
    英国纽卡斯尔大学医学院细胞医学研究所纽卡斯尔
    3.纽约州泰恩河畔纽卡斯尔医院NHS Trust，Freeman Hospital Newcastle Upon TyneUK

开放存取
脂肪肝疾病（S Harrison和J George，科室编辑）
首次在线：2017年11月16日

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以下专题集合的一部分：

    脂肪肝疾病的典型收藏

抽象
审查的目的

非酒精性脂肪肝（NAFLD）是西方世界最常见的肝病。浸润性肝活检仍然是NAFLD诊断和分期的金标准方法。这次审查的目的是总结近期有关NAFLD成像评估的研究。
最近的发现

控制性衰减参数（CAP）和磁共振成像质子衍生脂肪级分（MRI-PDFF）等新型方法对于脂肪变性评估似乎是有希望的，目前正在NAFLD中进行验证。纤维化可以通过瞬时弹性成像（TE）进行非侵入性评估，这是当前NAFLD中验证最好的测试。 MR弹性成像（MRE）对于纤维化检测显得非常敏感。没有成像技术可以准确地检测NASH。
概要

TE价格低廉，相对广泛，可以可靠地排除NAFLD的晚期纤维化。 MRI为脂肪变性和纤维化量化提供了最大的希望，但是还需要进一步验证这些技术。
关键词
NAFLD脂肪变性纤维化磁共振成像瞬态弹性成像成像非侵入性测试超声波