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TXL and CRV431 at the 22nd biennial HEP DART meeting [复制链接]

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发表于 2017-11-28 18:30 |只看该作者 |倒序浏览 |打印


Presentations
November 27, 2017
EDISON, N.J., Nov. 27, 2017 (GLOBE NEWSWIRE) -- ContraVir Pharmaceuticals, Inc. (NASDAQ:CTRV), a biopharmaceutical company focused on the development and commercialization of targeted antiviral therapies, announced today three abstracts were accepted for presentation at the 22nd biennial HEP DART meeting being held December 3-7 in Kona, Hawaii.

One oral presentation, and two poster presentations, will disclose the most recent findings on the company’s two novel drugs TXL™ and CRV431, for the treatment of chronic hepatitis B.

Presentation details are as follows:

Title        Tenofovir Exalidex (TXL) Formulation: Optimization Driven by Unique Physicochemical Properties
Abstract Number        27
Paper Status        Poster
Session Details        Poster Session
Dec 5, 2017
3:30 PM - 5:00 PM
Presenting Author        Dr. Robert Foster
         
Title        CRV431: Multiple Therapeutic Actions In vitro and In Vivo
Abstract Number        22
Paper Status        Poster
Session Details        Poster Session
Dec 5, 2017
3:30 PM - 5:00 PM
Presenting Author        Dr. Robert Foster
         
Title        Evidence Supporting Liver Targeting of Tenofovir Exalidex (TXL)
Abstract Number        15
Session Details        Oral Abstract Session VII
Dec 7, 2017
10:30 AM - 12:10 PM
Presenting Time        10:40 AM - 10:50 AM
Presenting Author        Dr. Robert Foster
ContraVir’s poster presentations from HEP DART 2017 will be available on the company’s website following their disclosure at the meeting at http://ir.contravir.com/events-and-presentations/presentations. For further information about HEP DART 2017 meeting visit: http://www.virology-education.com/event/upcoming/hep-dart-2017/

About ContraVir Pharmaceuticals

ContraVir is a biopharmaceutical company focused on the development and commercialization of targeted antiviral therapies with a specific focus on developing a potentially curative therapy for hepatitis B virus (HBV). The Company is developing two novel anti-HBV compounds with complementary mechanisms of action. TXL™, designed to deliver high intrahepatic concentrations of TFV while minimizing off-target effects caused by high levels of circulating TFV, recently completed a Phase 2a trial. CRV431, the other anti-HBV compound, is a next-generation cyclophilin inhibitor with a unique structure that increases its potency and selective index against HBV. In vitro and invivo studies have thus far demonstrated that CRV431 reduces HBV DNA and other viral proteins, including surface antigen (HBsAg). For more information visit www.contravir.com.

Forward Looking Statements
Certain statements in this press release are forward-looking within the meaning of the Private Securities Litigation Reform Act of 1995. These statements may be identified by the use of forward-looking words such as "anticipate," "believe," "forecast," "estimated" and "intend," among others. These forward-looking statements are based on ContraVir's current expectations and actual results could differ materially. There are a number of factors that could cause actual events to differ materially from those indicated by such forward-looking statements. These factors include, but are not limited to, substantial competition; our ability to continue as a going concern; our need for additional financing; uncertainties of patent protection and litigation; uncertainties with respect to lengthy and expensive clinical trials, that results of earlier studies and trials may not be predictive of future trial results; uncertainties of government or third party payer reimbursement; limited sales and marketing efforts and dependence upon third parties; and risks related to failure to obtain FDA clearances or approvals and noncompliance with FDA regulations. As with any drug candidates under development, there are significant risks in the development, regulatory approval, and commercialization of new products. There are no guarantees that future clinical trials discussed in this press release will be completed or successful, or that any product will receive regulatory approval for any indication or prove to be commercially successful. ContraVir does not undertake an obligation to update or revise any forward-looking statement. Investors should read the risk factors set forth in ContraVir's Form 10-K for the year ended June 30, 2017 and other periodic reports filed with the Securities and Exchange Commission.

For further information, please contact:

Sharen Pyatetskaya
Director of Investor Relations
[email protected]; (732) 902-4028

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Source: ContraVir Pharmaceuticals Inc

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发表于 2017-11-28 18:38 |只看该作者
说的是两种研发中的乙肝药物,TXL和CRV431 的在大会做报告

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发表于 2017-11-29 16:12 |只看该作者
演讲
2017年11月27日
2017年11月27日,新泽西州EDISON - 一家专注于抗病毒药物开发和商业化的生物制药公司ContraVir制药公司(纳斯达克:CTRV)今天宣布,三个摘要已被接受于12月3日至7日在夏威夷科纳举行的第22次双年度HEP DART会议。

一篇口头报告和两篇海报介绍,将公布两种新药TXL™和CRV431的最新发现,用于治疗慢性乙型肝炎。

介绍详情如下:

标题替诺福韦Exalidex(TXL)配方:由独特的物理化学性质驱动的优化
摘要编号27
纸张状态海报
会议详情海报会议
2017年12月5日
3:30 PM - 5:00 PM
介绍作者罗伯特福斯特博士
         
标题CRV431:在体外和体内的多种治疗作用
摘要编号22
纸张状态海报
会议详情海报会议
2017年12月5日
3:30 PM - 5:00 PM
介绍作者罗伯特福斯特博士
         
支持替诺福韦(TXL)肝靶向的证据
摘要编号15
会议详情口头简报会议七
2017年12月7日
上午10:30 - 下午12:10
提出时间上午10:40 - 上午10:50
介绍作者罗伯特福斯特博士
来自HEP DART 2017的ContraVir海报介绍将在公司网站上公布后在http://ir.contravir.com/events-and-presentations/presentations上公布。有关HEP DART 2017会议的更多信息,请访问:http://www.virology-education.com/event/upcoming/hep-dart-2017/

关于ContraVir制药

ContraVir是一家生物制药公司,专注于针对性抗病毒治疗的开发和商业化,特别关注开发一种潜在的治疗乙肝病毒(HBV)的疗法。公司正在开发两种具有互补作用机制的新型抗HBV化合物。 TXL™,旨在提供高肝内浓度的TFV,同时最大限度地减少高水平的循环TFV造成的脱靶效应,最近完成了2a期试验。另一种抗HBV化合物CRV431是下一代亲环素抑制剂,具有独特的结构,增加了其对HBV的效力和选择性指数。迄今为止,体外和体内研究显示CRV431减少了HBV DNA和其他病毒蛋白,包括表面抗原(HBsAg)。欲了解更多信息,请访问www.contravir.com。

前瞻性陈述
本新闻稿中的某些陈述是根据1995年“私人证券诉讼改革法案”的含义而具有前瞻性的。这些陈述可以通过使用“预测”,“相信”,“预测”等前瞻性词语加以识别。 “估计”和“打算”等等。这些前瞻性声明是基于ContraVir当前的预期,实际结果可能会有很大的不同。有许多因素可能导致实际事件与此类前瞻性陈述所表明的事件大不相同。这些因素包括但不限于实质性竞争;我们继续保持持续经营的能力;我们需要额外的融资;专利保护和诉讼的不确定性;对于长期和昂贵的临床试验的不确定性,早期研究和试验的结果可能不能预测未来的试验结果;政府或第三方付款人报销的不确定性;有限的销售和营销努力以及对第三方的依赖;以及未能获得FDA批准或不符合FDA规定的风险。与正在开发的候选药物一样,新产品的开发,监管审批和商业化也存在重大风险。无法保证本新闻稿中讨论的未来临床试验将会完成或成功,或者任何产品都将获得监管部门的批准,以证明其商业成功。 ContraVir不承担更新或修改任何前瞻性陈述的义务。投资者应阅读截至2017年6月30日止年度ContraVir 10-K表格中提出的风险因素以及向证券交易委员会提交的其他定期报告。

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发表于 2017-11-29 16:17 |只看该作者
ContraVir is developing CRV431 for treating hepatitis B and is currently preparing to enter IND-enabling studies based on strong preclinical data. CRV431 belongs to a known drug class of cyclophilin inhibitors derived from cyclosporine A, and was designed specifically to optimize potency and selectivity against HBV.
CRV431 works by disrupting certain host mechanisms that are “hijacked” by HBV as it replicates within liver cells. It is expected to be effective against all HBV genotypes due to the fact that it interrupts more than one point in the viral life cycle that are common in all HBV sub-types.
Potential Advantages of CRV431
Best-in-class potency and selective index against HBV
Interrupts HBV at multiple points, limiting replication and potential resistance
Blocks HBV entry into liver cells and suppresses HBsAg and HBeAg in vitro
Reduces HBV DNA without toxicity; prevents liver fibrosis in vivo



ContraVir is developing Tenofovir Exalidex (TXL™) for Hepatitis B in Phase 2 clinical studies. TXL™ is a novel lipid acyclic nucleoside phosphonate that delivers high intracellular concentrations of the active antiviral agent of tenofovir, marketed by Gilead as Viread®.
TXL™’s novel structure results in decreased circulating levels of tenofovir, lowering systemic exposure and thereby reducing the potential for renal side effects. TXL™ has completed a Phase 1 clinical trial in healthy volunteers, demonstrating a favorable safety, tolerability, and drug distribution profile.
ContraVir believes a potentially best-in-class antiviral like TXL™ can become the cornerstone of a curative combination therapy for hepatitis B. The combination would include multiple drugs that inhibit different points in the viral life cycle, such as ContraVir’s cyclosporine A-derived antiviral TXL™, which is currently in preclinical development. Learn more about TXL™ >>
Potential Advantages of TXL™ over Tenofovir
Increased efficacy by boosting bioavailability
Takes advantage of natural lipid uptake mechanisms
Decreased renal toxicity by reduced circulating TFV
97-fold more active against HBV in vitro

ContraVir正在开发用于治疗乙型肝炎的CRV431,目前正准备基于强大的临床前数据进入IND-Enable研究。 CRV431属于已知的衍生自环孢菌素A的亲环蛋白抑制剂的药物类别,并且专门设计用于优化针对HBV的效力和选择性。
CRV431通过破坏HBV在肝细胞内复制的某些宿主机制而起作用。由于它在病毒生命周期中中断了在所有HBV亚型中常见的一个以上的事实,所以预计对所有的HBV基因型都是有效的。
CRV431的潜在优势
同类最佳的抗乙肝病毒效力和选择性指标
中断HBV的多点,限制复制和潜在的阻力
阻断HBV进入肝细胞并在体外抑制HBsAg和HBeAg
减少HBV DNA无毒性;预防体内肝纤维化



ContraVir正在开发第二阶段临床研究中用于乙型肝炎的替诺福韦Exalidex(TXL™)。 TXL™是一种新型的脂质无环核苷膦酸酯,可提供细胞内高浓度的替诺福韦活性抗病毒药物,由Gilead以Viread®销售。
TXL™的新颖结构导致替诺福韦的循环水平下降,降低全身暴露,从而降低肾脏副作用的可能性。 TXL™已经完成了健康志愿者的第一阶段临床试验,证明了有利的安全性,耐受性和药物分布特征。
ContraVir认为,TXL™等潜在的同类最佳抗病毒药物可成为治疗乙型肝炎治疗性联合疗法的基石。该联合药物将包括抑制病毒生命周期中不同点的多种药物,如ContraVir的环孢素A衍生的抗病毒药物TXL™目前正处于临床前开发阶段。了解更多关于TXL™>>
TXL™对替诺福韦的潜在优势
通过提高生物利用度来提高疗效
利用天然脂质摄取机制
通过降低循环TFV降低肾毒性
在体外对乙型肝炎的活性高出97倍
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