维生素D在肝细胞癌中作用的新见解

StephenW

      Review
New insights into the role of vitamin D in hepatocellular carcinoma
Dong-Bo Wu, Meng-Lan Wang, En-Qiang Chen & Hong Tang
Pages 1-8 | Received 24 Aug 2017, Accepted 14 Nov 2017, Accepted author version posted online: 15 Nov 2017, Published online: 21 Nov 2017

    Download citation https://doi.org/10.1080/17474124.2018.1406307



ABSTRACT

Introduction: In addition to being crucial for host immune defense, vitamin D is involved in cell proliferation, apoptosis, differentiation, inflammation, invasion and metastasis, angiogenesis and micro-RNA modulation. To date, clinical studies have demonstrated that vitamin D deficiency is common not only in patients with chronic liver diseases but also in those with hepatocellular carcinoma (HCC). Experimental studies have also demonstrated that vitamin D and its receptors are related to the occurrence of HCC and the prognoses of patients with HCC.

Areas covered: In this review, we discuss the potential anti-tumor role of vitamin D in HCC based on current findings from epidemiological studies, basic science, and clinical studies and provide new insights into the pathogenesis and treatment of HCC.

Expert commentary: Recent studies have revealed the anti-tumor effects of vitamin D to a certain degree. Vitamin D and its analogs may provide new treatment targets and prognostic factors for HCC that might be essential for the primary or secondary prevention of HCC and the monitoring of its progression.
KEYWORDS: Chronic liver disease, hepatocellular carcinoma, vitamin D, deficiency, treatment target
Additional information
Funding
This work was supported by grants from the Science and Technology Support Program of the Sichuan Province, China (2015SZ0049).

StephenW

评论
维生素D在肝细胞癌中作用的新见解
吴东波，王孟兰，陈恩强，唐红
1-8页|收到2017年8月24日，接受2017年11月14日，接受作者版本发布在线：2017年11月15日，在线发表时间：2017年11月21日

    下载引用https://doi.org/10.1080/17474124.2018.1406307



抽象

简介：维生素D除了对宿主免疫防御至关重要之外，还涉及细胞增殖，凋亡，分化，炎症，侵袭和转移，血管生成和微RNA调控。迄今为止，临床研究已经证明，维生素D缺乏不仅在慢性肝病患者中是常见的，而且在肝细胞癌（HCC）患者中也是常见的。实验研究也表明，维生素D及其受体与HCC的发生和HCC患者的预后有关。

所涵盖的领域：在这篇综述中，我们根据目前流行病学研究，基础科学和临床研究的发现，讨论维生素D在HCC中潜在的抗肿瘤作用，并为HCC的发病机制和治疗提供新的见解。

专家评论：近期研究发现维生素D的抗肿瘤作用有一定的效果。维生素D及其类似物可能为HCC的治疗目标和预后提供了新的因素，可能对肝癌的一级或二级预防和监测其发展至关重要。
关键词：慢性肝病，肝癌，维生素D缺乏症，治疗目标
附加信息
资金
这项工作得到了四川省科技支撑计划（2015SZ0049）的资助。