慢性乙型肝炎患者使用瞬态弹性成像和天冬氨酸氨基转移酶 -

StephenW

Acta Med Indones. 2017 Jul;49(3):220-226.
Treatment Response Monitoring of Chronic Hepatitis B Patients using Transient Elastography and Aspartate Aminotransferase-to-Platelet Ratio Index (APRI).Tenggara IR1, Lesmana CR, Gani RA.
Author information
1Department of Internal Medicine, Atma Jaya University, Jakarta, Indonesia. [email protected].

AbstractBACKGROUND: Hepatitis B is endemic in Indonesia and treatment response need to be monitored during and after antiviral therapy. Liver stiffness measurement and alanine aminotransferase-to-platelet ratio index (APRI) are noninvasive method to detect liver fibrosis available in Indonesia. However, little is known about their ability to evaluate treatment response in chronic hepatitis B (CHB) patients in Indonesia. This study aimed to investigate liver stiffness changes by transient elastography (TE) and APRI before and after one-year oral antiviral treatment in CHB patients and the correlation between TE and APRI.
METHODS: this study was retrospective cohort on CHB patients in CiptoMangunkusumo Hospital, Jakarta who uderwent treatment between January 2012 and December 2014. Patients received oral antiviral treatment with newer nucleoside analogues (entecavir or telbivudine) for at least one year. TE and APRI were obtained before and after treatment. TE and APRI reductions were analyzed statistically with Spearman's test.
RESULTS: a total of 41 patients were enrolled in this study. Median liver stiffness value was significantly reduced from 10.8 to 5.9 kPa after oral antiviral treatment (p<0.001, Wilcoxon's test). Median APRI was also significantly reduced from 1.13 to 0.43 after treatment (p<0.001, Wilcoxon's test). The correlation between liver stiffness and APRI before treatment was weak (r=0.40), but it was strong after treatment (r=0.73).
CONCLUSION: the liver stiffness measured with transient elastography and APRI significantly decreased after one year of antiviral treatment in chronic HBV patients. There was a significant correlation between TE and APRI after one year of treatment.


KEYWORDS: antiviral therapy; aspartate aminotransferase-to-platelet ratio index (APRI); chronic hepatitis B; liver stiffness measurement; transient elastography

PMID:29093232

StephenW

Acta Med Indones。 2017年7月; 49（3）：220-226。
慢性乙型肝炎患者使用瞬态弹性成像和天冬氨酸氨基转移酶 - 血小板比值指数（APRI）的治疗反应监测。
Tenggara IR1，Lesmana CR，Gani RA。
作者信息

1
    印度尼西亚雅加达Atma Jaya大学内科医学系。 [email protected]。

抽象
背景：

乙型肝炎在印度尼西亚是流行的，需要在抗病毒治疗期间和之后监测治疗反应。肝硬度测量和丙氨酸氨基转移酶 - 血小板比指数（APRI）是检测印度尼西亚肝纤维化的无创方法。然而，关于评估印度尼西亚慢性乙型肝炎（CHB）患者治疗反应的能力知之甚少。本研究旨在探讨CHB患者一年口服抗病毒治疗前后的瞬时弹性成像（TE）和APRI的肝硬度变化以及TE和APRI的相关性。
方法：

本研究是对雅加达CiptoMangunkusumo医院CHB患者的回顾性队列研究，他们在2012年1月至2014年12月期间接受了治疗。患者接受口服抗病毒治疗，使用更新的核苷类似物（恩替卡韦或替比夫定）至少1年。 TE和APRI治疗前后获得。用Spearman's检验对TE和APRI的降低进行了统计分析。
结果：

共有41名患者参加了这项研究。口服抗病毒治疗后肝硬度值中值从10.8降至5.9kPa（p <0.001，Wilcoxon试验）。治疗后APRI中位数也从1.13显着降低至0.43（P <0.001，Wilcoxon检验）。治疗前肝硬化与APRI之间的相关性较弱（r = 0.40），但治疗后较强（r = 0.73）。
结论：

慢性乙型肝炎患者经过一年的抗病毒治疗后，用瞬态弹性成像和APRI测得的肝硬度显着降低。经过一年的治疗后，TE和APRI有显着的相关性。
关键词：

抗病毒治疗;天冬氨酸氨基转移酶与血小板比值指数（APRI）;慢性乙型肝炎;肝硬度测量;瞬时弹性成像

结论：
    29093232