γ - 谷氨酰转肽酶与血小板比值不优于中国CHB患者肝纤维化

StephenW

Sci Rep. 2017 Aug 17;7(1):8543. doi: 10.1038/s41598-017-09234-w.
Gamma-glutamyl-transpeptidase to platelet ratio is not superior to APRI,FIB-4 and RPR for diagnosing liver fibrosis in CHB patients in China.Huang R1, Wang G1, Tian C1, Liu Y2, Jia B1, Wang J1, Yang Y1, Li Y1, Sun Z1, Yan X1, Xia J1, Xiong Y1, Song P1, Zhang Z1, Ding W3, Wu C4.
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AbstractThe gamma-glutamyl transpeptidase to platelet ratio (GPR) is a novel index to estimate liver fibrosis in chronic hepatitis B (CHB). Few studies compared diagnostic accuracy of GPR with other non-invasive fibrosis tests based on blood parameters. We analyzed diagnostic values of GPR for detecting liver fibrosis and compared diagnostic performances of GPR with APRI (aspartate aminotransferase-to-platelet ratio index), FIB-4 (fibrosis index based on the four factors), NLR (neutrophil-to-lymphocyte ratio), AAR (aspartate aminotransferase/alanine aminotransferase ratio) and RPR (red cell distribution width-to-platelet ratio) in HBeAg positive CHB and HBeAg negative CHB. We found AUROCs of GPR in predicting significant liver fibrosis, advanced liver fibrosis and liver cirrhosis were 0.732 (95% CI 0.663 to 0.801), 0.788 (95% CI 0.729 to 0.847) and 0.753 (95% CI 0.692 to 0.814), respectively. Further comparisons showed the diagnostic performance of GPR was not significantly different with APRI, FIB-4 and RPR in identifying significant fibrosis, advanced fibrosis and cirrhosis, but it was significantly superior to AAR and NLR in both HBeAg positive CHB and HBeAg negative CHB. In conclusion, GPR does not show advantages than APRI, FIB-4 and RPR in identifying significant liver fibrosis, advanced liver fibrosis and liver cirrhosis in both HBeAg positive CHB and HBeAg negative CHB in China.


PMID:28819319DOI:10.1038/s41598-017-09234-w

StephenW

Sci Rep。2017 Aug 17; 7（1）：8543。 doi：10.1038 / s41598-017-09234-w。
γ - 谷氨酰转肽酶与血小板比值不优于中国CHB患者肝纤维化的APRI，FIB-4和RPR。
黄R1，王G1，田C1，刘Y2，贾B1，王J 1，杨Y1，李Y1，孙梓Yan，阎X1，夏杰1，熊Y1，宋P1，张Z1，丁W3，吴C4。
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γ-谷氨酰转肽酶与血小板比（GPR）是评估慢性乙型肝炎（CHB）肝纤维化的新指标。几项研究比较了基于血液参数的GPR与其他非侵入性纤维化检测的诊断准确性。我们分析了GPR检测肝纤维化的诊断价值，并比较了GPR与APRI（天冬氨酸转氨酶 - 血小板比值指数），FIB-4（基于四个因素的纤维化指数），NLR（嗜中性粒细胞与淋巴细胞比例），HBeAg阳性CHB和HBeAg阴性CHB中的AAR（天冬氨酸氨基转移酶/丙氨酸氨基转移酶比率）和RPR（红细胞分布宽度 - 血小板比）。我们发现AUROCs预测肝纤维化程度明显，肝纤维化程度和肝硬化分别为0.732（95％CI 0.663〜0.801），0.788（95％CI 0.729〜0.847）和0.753（95％CI 0.692〜0.814）。进一步比较表明，APRI，FIB-4和RPR在鉴别显着纤维化，晚期纤维化和肝硬化中GPR的诊断性能没有显着差异，但在HBeAg阳性CHB和HBeAg阴性CHB中均显着优于AAR和NLR。总之，GPR在中国HBeAg阳性CHB和HBeAg阴性CHB中均未显示APRI，FIB-4和RPR鉴别肝纤维化，晚期肝纤维化和肝硬化的优势。

结论：
    28819319
DOI：
    10.1038 / s41598-017-09234-W