Core mutant, genotype, HCC of CHB in Guangxi China

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J Med Virol 2002 Sep;68(1):33-40Related Articles, Links


Core promoter mutations (A1762T and G1764A) and viral genotype in chronic hepatitis B and hepatocellular carcinoma in Guangxi, China.

Fang ZL, Yang J, Ge X, Zhuang H, Gong J, Li R, Ling R, Harrison TJ.

Centre for Hepatology, Royal Free and University College Medical School,
University College London, London, United Kingdom.

Hepatitis B viruses (HBV) with core promoter mutations (A(1762)T, G(1764)A)
were found in a previous study to be highly prevalent in patients from
Guangxi, China with hepatocellular carcinoma (HCC). The aim of this study
was to determine whether the mutations are prevalent in areas of Guangxi
with high and lower incidences of HCC and whether they are associated with other severe sequelae of chronic hepatitis B, including the development of cirrhosis. In addition, the genotypes of the various HBV sequences were determined. Core promoter mutations were significantly more common in HCC patients than asymptomatic carriers from both regions of Guangxi and also were common in patients with cirrhosis and chronic hepatitis. The data also support the hypothesis that genotype C HBV causes more severe liver disease than does genotype B. J. Med. Virol. 68:33-40, 2002. Copyright 2002 Wiley-Liss, Inc.

PMID: 12210428 [PubMed - in process]

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Guangxi, China.
University College London, London, United Kingdom.
Core mutant, genotype, HCC of CHB