蘑菇凝集素通过TLR6信号传导克服乙型肝炎病毒耐性

StephenW

Sci Rep. 2017 Jul 19;7(1):5814. doi: 10.1038/s41598-017-06261-5.
Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling.He M1, Su D1, Liu Q1, Gao W1, Kang Y2.
Author information
1State Key Laboratory for Agro-Biotechnology, College of Biological Science, China Agricultural University, Beijing, China.2State Key Laboratory for Agro-Biotechnology, College of Biological Science, China Agricultural University, Beijing, China. [email protected].

AbstractCurrently, chronic hepatitis B virus (HBV) infection remains a serious public health problem in the world. Recombinant HBV vaccine, as a preventive strategy against HBV infection, generates high antibody level, but it is not effective to activate innate and cellular immunity for chronic HBV infection therapy. Lectins from mushroom are natural and active proteins which have been shown important biological functions. However, little is known about the immunological mechanism engaged by mushroom lectins. Here we report that, lectin from Pleurotus ostreatus (POL) stimulated innate response by activating Toll-like receptor 6 signal pathway of dendritic cells. Subsequently POL enhanced HBV specific antibody level and follicular helper T cells response which overcame HBV tolerance in transgenic mice. This study suggests a novel mechanism for POL acting on immune response and a therapeutic approach to break HBV tolerance.


PMID:28724955PMCID:PMC5517594DOI:10.1038/s41598-017-06261-5

StephenW

Sci Rep。2017 Jul 19; 7（1）：5814。 doi：10.1038 / s41598-017-06261-5。

蘑菇凝集素通过TLR6信号传导克服乙型肝炎病毒耐受性。
他M1，苏D1，刘Q1，高W1，康Y2。
作者信息

1
    中国农业大学生物科学学院农业生物技术国家重点实验室，北京，中国。
2
    中国农业大学生物科学学院农业生物技术国家重点实验室，北京，中国。 [email protected]。

抽象

目前，慢性乙型肝炎病毒（HBV）感染仍然是世界上严重的公共卫生问题。重组HBV疫苗作为预防HBV感染的策略，产生高抗体水平，但对于慢性HBV感染治疗激活先天和细胞免疫无效。来自蘑菇的凝集素是已经显示出重要生物功能的天然和活性蛋白质。然而，关于蘑菇凝集素的免疫机制知之甚少。在这里我们报告说，来自侧耳菇（POL）的凝集素通过激活树突状细胞的Toll样受体6信号通路刺激天然的反应。随后，POL增强HBV特异性抗体水平和滤泡辅助T细胞应答，克服转基因小鼠HBV耐受。这项研究提出了POL对免疫应答的一种新机制，也是一种破坏HBV耐受性的治疗方法。

结论：
    28724955
PMCID：
    PMC5517594
DOI：
    10.1038 / s41598-017-06261-5

StephenW

https://www.nature.com/articles/s41598-017-06261-5