儿童期乙型肝炎病毒抗体滴度随时间变化：2012年至2015年在韩

StephenW

              
        BMC Pediatr. 2017 Jul 14;17(1):164. doi: 10.1186/s12887-017-0924-7.
Changes in hepatitis B virus antibody titers over time among children: a single center study from 2012 to 2015 in an urban of South Korea.Lee KH1, Shim KS1, Lim IS1,2, Chae SA1,2, Yun SW1,2, Lee NM1, Choi YB1, Yi DY3,4.
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AbstractBACKGROUND: Hepatitis B virus (HBV) infection is the most common cause of liver disease in endemic areas such as South Korea. After HBV vaccination, hepatitis B surface antibody (HBsAb) titers gradually decrease. Trends in HBsAb titers have not been evaluated among children in South Korea over the past decade.
METHODS: We screened 6155 patients (aged 7 months to 17 years) who underwent HBV antigen/antibody testing at Chung-Ang University Hospital from May 2012 to April 2015. Titer criteria were defined as follows: positive, titer ≥100 IU/L; weakly positive, titer 10-99 IU/L; and negative, titer <10 IU/L. We also compared titers before and 1 month after a single booster vaccination.
RESULTS: Of the 5655 patients included, 3016 were male and 5 (0.09%) tested positive for HBV surface antigen. A marked reduction in antibody titer was observed until 4 years of age. Thereafter, the titers showed fluctuating decreases. HBsAb titers reached their lowest levels by 14 years of age. After 7 years of age, 50% of patients tested negative for HBsAb. Simple linear analysis showed that the titer reached levels of <10 IU/L and zero at 12.9 and 13.4 years of age, respectively. 1 month after a single booster vaccination was administered to those who were HBsAb-negative (n = 72), 69 children (96%) had developed antibodies while 3 (4%) remained HBsAb-negative.
CONCLUSIONS: In conclusion, the continuous reduction in HBsAb titers over time and in each age group was confirmed. The titer level was shown significant decline until age 4. More than half of the sample had negative titers after age 7 years. After booster vaccination, most of child significantly increase titer level.

StephenW

BMC Pediatr。 2017年7月14日; 17（1）：164。 doi：10.1186 / s12887-017-0924-7。
儿童期乙型肝炎病毒抗体滴度随时间变化：2012年至2015年在韩国城市的单中心研究。
Lee KH1，Shim KS1，Lim IS1,2，Chae SA1,2，Yun SW1,2，Lee NM1，Choi YB1，Yi DY3,4。
作者信息
抽象
背景：

乙型肝炎病毒（HBV）感染是南韩流行地区肝病最常见的原因。乙型肝炎疫苗接种后，乙型肝炎表面抗体（HBsAb）滴度逐渐降低。过去十年来，韩国的儿童HBsAb滴度尚未得到评估。
方法：

我们对2012年5月至2015年4月在中​​安大学医院接受HBV抗原/抗体检测的6155例（7个月至17岁）患者进行筛查。滴度标准定义如下：阳性，滴度≥100IU / L;弱阳性，滴度为10-99IU / L;而阴性，滴度<10IU / L。我们还比较了单次加强免疫接种后1个月之前的滴度。
结果：

在5655例患者中，男性为3016例，HBV表面抗原阳性为5例（0.09％）。观察到抗体滴度显着降低至4岁。此后，滴度显示波动下降。 HBsAb滴度达到14岁以下的最低水平。 7岁以后，50％的患者对HBsAb阴性。简单的线性分析表明，滴度分别达到<10 IU / L，零点为12.9和13.4岁。对HBsAb阴性者（n = 72）进行单次加强免疫接种后1个月，69名儿童（96％）发生了抗体，3名（4％）仍然是HBsAb阴性。
结论：

总之，随着时间的推移和每个年龄组的HBsAb滴度的持续降低被证实。滴度水平显着下降，直到4岁。超过一半的样品在7岁以后具有阴性滴度。加强免疫后，大部分儿童滴度显着提高。