[2006年和2014年中国1-29岁年轻人的HBV易感性流行病学特征：根

StephenW

Zhonghua Yu Fang Yi Xue Za Zhi. 2017 Jul 6;51(7):581-586. doi: 10.3760/cma.j.issn.0253-9624.2017.07.002.
[The epidemiological characteristics of HBV susceptibility in 1-29 years old young people in China in 2006 and 2014: based on the national sero-survey data analysis]. [Article in Chinese;  Abstract available in Chinese from the publisher]
Zheng H1, Wang FZ, Zhang GM, Miao N, Sun XJ, Cui FQ.
Author information
1Epidemiology Division, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Abstractin                                English, Chinese
Objective: To analyze the epidemiological characteristics of HBV susceptible people in 1-29 years old people in 2006 and 2014 in China. Method: Data is from the 2006 and 2014 national sero-survey, and both of them were conducted in 160 disease surveillance points of 31 provinces (excluding Hong Kong, Macao Special Administrative Region and Taiwan province) in China. We used the centralized face-to face investigation method to collect basic information including birth date, gender, ethnicity, resident place, hepatitis B vaccination (HepB) history and so on, and 5 ml venous blood was collected for all subjects to test the sero-markers of HBsAg, anti-HBs and anti-HBc. We definite the HBV susceptible people as the HBsAg, anti-HBs and anti-HBc all negative together. And we use chi-square to analyze the epidemiological characteristics of HBV susceptibility in 1-29 years old young people in 2006 and 2014, and use multiple factors logistic regression to analyze the affect factors on HBV susceptible appearing in people with HepB vaccination. Result: In 2006 and 2014 sero-surveys, the investigated 1-29 year-old people were 49 849 and 31 713, respectively. And compared with 2006, the proportion of HBV susceptible people with HepB among 1-29 in 2014 increased from 20.87% (10 401) to 28.55% (9 055) (χ(2)=630.69, P<0.001); and the proportion of susceptible people without HepB decreasing from 15.02% (7 485) to 7.66% (2 460) (χ(2)=953.73, P<0.001). Compared with Han nationality, the high risk of susceptible appearing in minority people after HepB vaccination (OR=1.38). And compared with less than 3 doses HepB vaccination, the more than 3 doses vaccination could reduce the anti-HBs disappearing rate (OR=0.68); Compared with one year after last dose vaccination, the 2-4 years interval (OR=3.33) and more than 5 years interval (OR=6.53) would have high risk for anti-HBs disappearing. All above were P<0.001. In western area, the proportion of susceptible people without HepB (9.58%, 1 047/2 460) was higher than the proportion in eastern (6.30%, 657/2 460) and middle area (7.30%, 756/2 460) (P<0.001). Conclusion: The HepB coverage maintained in high level in 1-4 years old children. The HBV susceptible proportion mainly concentrated in 15-29 years old people, and the immunization gap was in western, rural areas and minority peoples.


KEYWORDS: Disease susceptibility; Epidemiologic studies; Hepatitis B virus

PMID:28693080

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StephenW

中华宇方易学扎志。 2017年7月6日; 51（7）：581-586。 Doi：10.3760 / cma.j.issn.0253-9624.2017.07.002。
[2006年和2014年中国1-29岁年轻人的HBV易感性流行病学特征：根据国家血清调查数据分析]。
[中文摘要]摘要]
郑和王菲，张通，苗妮，孙旭，崔福奎。
作者信息

1
中国疾病预防控制中心流行病学教研室，北京100050。

抽象英文，中文

目的：分析中国2006年和2014年1-29岁人群HBV易感人群的流行病学特征。方法：数据来自2006年和2014年全国血清调查，两者进行了160次癌症监测点。在多样性面孔，性别，居住地，乙型肝炎疫苗（HepB），特别是历史等方面收集所有受试者的5ml静脉血，以测试HBsAg，抗HBs和抗HBc的血清标志物。我们将HBV易感人群定义为HBsAg，抗HBs和抗HBc都是阴性的。我们使用卡方分析2006年和2014年1-29岁年轻人HBV易感性的流行病学特征，并采用多因素Logistic回归分析HepB疫苗接种人群中HBV suscep特异性的影响因素。结果：2006年和2014年血清调查显示，1-29岁的人分别为49 849人和31 713人。而2006年，HBV易感人群中HepB的比例（Χ（2）= 630.69，P <0.001）;不含HepB的易感人群比例从15.02％（7 485）降至（0.41）（χ（2）= 953.73，P <0.001）。与汉族相比，HepB疫苗接种后（OR = 1.38），少数民族易感染高风险疫苗接种疫苗接种3次以上可降低抗HBs消失率（OR = 0.68）;与上次接种疫苗接种后一年相比，2-4年间隔（OR = 3.33）和5年以上间隔（OR = 6.53），抗HBs消失风险较高。以上均为P <0.001。在西部地区，不含HepB的易感人群比例（9.58％，1（6.30％，756/2 460）（P <0.001））。结论HepB覆盖率保持在1（7.30％，757/2 460） -4岁儿童，HBV易感性浓度集中在15-29岁的人群中，免疫接种差距在西部，农村和个体人群中。
关键词：

疾病易感性;流行病学研究;乙肝病毒

结论：
28693080