中国乙型肝炎病毒性肝硬化患者肝细胞癌与2型糖尿病的关联

StephenW

Med Sci Monit. 2017 Jul 9;23:3324-3334.
Association Between Hepatocellular Carcinoma and Type 2 Diabetes Mellitus in Chinese Hepatitis B Virus Cirrhosis Patients: A Case-Control Study.Han H1,2, Deng H1,2, Han T3, Zhao H4, Hou F1, Qi X1.
Author information
1Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).2Postgraduate College, Dalian Medical University, Dalian, Liaoning, China (mainland).3Department of Oncology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).4Medical Ethical Committee, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland).

AbstractBACKGROUND Whether the presence of type 2 diabetes mellitus (T2DM) increases the risk of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) cirrhosis patients is controversial. We conducted a retrospective case-control study to evaluate this issue. MATERIAL AND METHODS We considered all patients diagnosed with HBV-related liver cirrhosis at our hospital from July 2011 to June 2014. The case (n=91) and control (n=91) groups were HBV cirrhosis patients with and without T2DM, respectively. They were matched at a ratio of 1: 1 according to the individual age (±2 years) and same sex and Child-Pugh score. RESULTS None of the baseline data were significantly different between the 2 groups. The percentage of HCC was similar between the 2 groups (case versus control group: 34.1% versus 46.2%, P=0.13). In the case group, sex (P=0.002), alkaline phosphatase (P<0.001), g-glutamine transferase (P=0.001), and sodium (P=0.003) were associated with the risk of HCC. In the control group, platelet (P=0.041), alanine aminotransferase (P=0.034), aspartate aminotransferase (P=0.026), alkaline phosphatase (P<0.001), and γ-glutamine transferase (P<0.001) were associated with the risk of HCC. CONCLUSIONS T2DM may not be a risk factor for the presence of HCC in HBV cirrhosis.


PMID:28689209

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StephenW

Med Sci Monit。 2017年7月9日; 23：3324-3334。
中国乙型肝炎病毒性肝硬化患者肝细胞癌与2型糖尿病的关联：病例对照研究。
韩H1,2，邓H1,2，韩T3，赵H4，侯F1，齐X1。
作者信息

1
    中国辽宁沉阳市沉阳军区综合医院消化内科肝硬化研究组（大陆）。
2
    大连医科大学研究生院，大连，辽宁，中国大陆。
3
    沉阳军区综合医院肿瘤科，辽宁沉阳，中国大陆。
4
    中国辽宁沉阳市沉阳军区综合医院伦理委员会。

抽象

背景技术无论2型糖尿病（T2DM）的存在是否增加乙肝病毒（HBV）肝硬化患者肝细胞癌（HCC）的风险是有争议的。我们进行了回顾性病例对照研究来评估这个问题。材料和方法我们考虑了2011年7月至2014年6月在我院诊断为HBV相关性肝硬化的所有患者。病例（n = 91）和对照组（n = 91）分别为有无T2DM的HBV肝硬化患者。根据个体年龄（±2岁）和相同的性别和Child-Pugh评分，比例为1：1。结果两组之间的基线数据没有显着差异。两组之间HCC的百分比相似（病例与对照组比较，分别为34.1％，46.2％，P = 0.13）。在病例组中，性别（P = 0.002），碱性磷酸酶（P <0.001），g-谷氨酰胺转移酶（P = 0.001）和钠（P = 0.003）与HCC的风险相关。对照组血小板（P = 0.041），丙氨酸氨基转移酶（P = 0.034），天冬氨酸氨基转移酶（P = 0.026），碱性磷酸酶（P <0.001）和γ-谷氨酰胺转移酶（P <0.001） HCC风险。结论T2DM可能不是HCC在HBV肝硬化中的存在的危险因素。

结论：
    28689209