剪切波弹性蛋白在评估慢性乙型肝炎患者肝细胞癌风险中的

StephenW

Gut Liver. 2017 Jun 27. doi: 10.5009/gnl16521. [Epub ahead of print]
Role of Shear Wave Elastography in Evaluating the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B.Jeong JY1, Sohn JH1, Sohn W2, Park CH1, Kim TY1, Jun DW3, Kim Y4, Jeong WK5.
Author information
1Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.2Hepatology Center, Bundang Jesaeng General Hospital, Seongnam, Korea.3Department of Internal Medicine, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Korea.4Department of Radiology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.5Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

AbstractBackground/Aims: To investigate the use of measurements of liver stiffness (LS) by two-dimensional real-time shear wave elastography (SWE) for predicting the development of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB).
Methods: We retrospectively collected data on 291 enrolled patients with CHB whose LS had been measured using SWE.
Results: The mean age of the patients was 46.8 years; males predominated (67%), and 40 of the patients (14%) had clinical cirrhosis. Among the patients, 165 (56.7%) received antiviral treatment. The median LS value was 7.4 kPa, and the median follow-up period was 35.8 months (range, 3.0 to 52.8 months). During follow-up, HCC developed in 13 patients (4.5%), and the cumulative incidence rates of HCC at 1, 2, and 4 years were 1.1%, 3.6%, and 8.4%, respectively. Based on a multivariate analysis, older age (≥50 years) and higher LS value (≥10 kPa) were independently associated with the risk of developing HCC (hazard ratio [HR], 4.53, p=0.023; and HR, 4.08, p=0.022). The cumulative incidence rate of HCC was significantly higher in patients with higher LS values (≥10 kPa) than in those with lower LS values (<10 kPa) (p=0.001).
Conclusions: Increased LS measured by SWE at any time point regardless of antiviral treatment is associated with an increased risk of HCC in patients with CHB.


KEYWORDS: Carcinoma, hepatocellular; Elastography, shear wave; Hepatitis B, chronic; Liver stiffness

PMID:28651307DOI:10.5009/gnl16521

StephenW

肠肝2017年6月27日。doi：10.5009 / gnl16521。 [提前印刷]
剪切波弹性蛋白在评估慢性乙型肝炎患者肝细胞癌风险中的作用
Jeong JY1，Sohn JH1，Sohn W2，Park CH1，Kim TY1，Jun DW3，Kim Y4，Jeong WK5。
作者信息

1
    韩阳大学医学院汉阳大学古里医院内科系韩国古里。
2
    肝脏病中心，韩国龙门市丹东市综合医院。
3
    韩阳大学医学院汉阳医院内科系，韩国首尔。
4
    韩阳大学医学院汉阳大学古里医院放射科，韩国古里。
五
    韩国首尔Sungkyunkwan大学医学院三星医学中心放射科和影像科学中心。

抽象
背景/目的：

研究采用二维实时剪切波形弹性成像（SWE）测量肝硬化（LS）对慢性乙型肝炎（CHB）患者肝细胞癌（HCC）发展的预测。
方法：

我们回顾性地收集了291名使用SWE测量LS的CHB患者的数据。
结果：

患者平均年龄46.8岁;男性占主导地位（67％），40例（14％）患有临床肝硬化。其中165例（56.7％）接受抗病毒治疗。中位LS值为7.4 kPa，中位随访时间为35.8个月（范围为3.0〜52.8个月）。随访期间，肝癌发生13例（4.5％），1年，2年和4年HCC累积发生率分别为1.1％，3.6％和8.4％。根据多变量分析，年龄（≥50岁）和较高的LS值（≥10kPa）与发生HCC的风险独立相关（风险比[HR]，4.53，p = 0.023; HR为4.08，p = 0.022）。 LS值较高（≥10kPa）的患者HCC累积发生率明显高于LS值（<10 kPa）（p = 0.001）。
结论：

无论抗病毒治疗如何，SWE在任何时间点测量的LS增加与CHB患者HCC风险增加有关。
关键词：

癌，肝细胞;弹性成像，剪切波;乙型肝炎，慢性乙型肝炎肝硬度

结论：
    28651307
DOI：
    10.5009 / gnl16521

StephenW

http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl16521