亚型病毒颗粒上的乙型肝炎表面抗原降低了抗HBs​​抗体对

StephenW

Virology. 2017 Jun 9;509:67-70. doi: 10.1016/j.virol.2017.05.017. [Epub ahead of print]
Hepatitis B surface antigen on subviral particles reduces the neutralizing effect of anti-HBs antibodies on hepatitis B viral particles in vitro.Rydell GE1, Prakash K2, Norder H3, Lindh M4.
Author information
1Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg, 41346 Gothenburg, Sweden. Electronic address: [email protected].2Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg, 41346 Gothenburg, Sweden. Electronic address: [email protected].3Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg, 41346 Gothenburg, Sweden. Electronic address: [email protected].4Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg, 41346 Gothenburg, Sweden. Electronic address: [email protected].

AbstractDuring hepatitis B virus (HBV) infections subviral particles (SVP) consisting mainly of hepatitis B surface antigen are present at much higher concentration than viral particles (VP) in serum. To investigate reasons for this excess of SVP production, SVP and VP were fractionated on a Nycodenz gradient and analyzed for HBV infection of HepG2-NTCP cells with and without anti-HBs antibodies. Our findings showed that SVP significantly reduced the neutralization of VP by anti-HBs, while SVP had little effect on viral entry, supporting the assumption that SVP serve as decoy facilitating cell-to-cell spread of HBV in the presence of neutralizing antibodies.

Copyright © 2017 Elsevier Inc. All rights reserved.

KEYWORDS: Attachment; Dane particles; HBV; HBsAg; Neutralisation

PMID:28605637DOI:10.1016/j.virol.2017.05.017

StephenW

病毒学。 2017年6月9日; 509：67-70。 doi：10.1016 / j.virol.2017.05.017。 [提前印刷]
亚型病毒颗粒上的乙型肝炎表面抗原降低了抗HBs​​抗体对乙型肝炎病毒颗粒体外的中和作用。
Rydell GE1，Prakash K2，Norder H3，Lindh M4。
作者信息

1
    传染病司，Sahlgrenska学院，哥德堡大学，41346哥德堡，瑞典。电子地址：[email protected]。
2
    传染病司，Sahlgrenska学院，哥德堡大学，41346哥德堡，瑞典。电子地址：[email protected]。
3
    传染病司，Sahlgrenska学院，哥德堡大学，41346哥德堡，瑞典。电子地址：[email protected]。
4
    传染病司，Sahlgrenska学院，哥德堡大学，41346 Gothenburg，瑞典。电子地址：[email protected]。

抽象

乙型肝炎病毒（HBV）感染主要由乙型肝炎表面抗原组成的亚型病毒颗粒（SVP）的浓度高于血清中的病毒颗粒（VP）。为了研究SVP生产过量的原因，将SVP和VP按Nycodenz梯度分级，并分析了具有和不具有抗HBs抗体的HepG2-NTCP细胞的HBV感染。我们的研究结果表明，SVP显着降低了抗HBs​​的VP中和，SVP对病毒进入影响不大，支持SVP在中和抗体存在下促进HBV的细胞传播扩散的假设。

版权所有©2017 Elsevier Inc.保留所有权利。
关键词：

附件;丹麦颗粒HBV;乙肝表面抗原;中和

结论：
    28605637
DOI：
    10.1016 / j.virol.2017.05.017