喝咖啡或茶歇以保护你的肝脏

StephenW

Public Release: 6-Jun-2017
                                    Take a coffee or tea break to protect your liver                                

New study indicates that drinking even a few cups a day may prevent hardening of the liver, reports the Journal of Hepatology

               

Elsevier

   

            
  
  
              
  IMAGE: Using data from the Rotterdam Study researchers determined that frequent coffee and herbal tea consumption were inversely related with liver stiffness but not steatosis in the general population.     view more
  

Credit: L. Alferink and S. Darwish Murad

                      Amsterdam, The Netherlands, June 6, 2017 - Chronic liver diseases rank as the 12th cause of death worldwide and many of these disorders are associated with unhealthy lifestyles. Conversely, a healthier lifestyle can help prevent or reverse liver disease. Liver-related mortality is closely related to the development of cirrhosis, the final consequence of progressive fibrosis, i.e. scarring of the liver resulting from chronic inflammation. According to a new study published in the Journal of Hepatology, researchers found that drinking coffee and herbal tea may protect against liver fibrosis, estimated as the degree of liver stiffness, which is high in extensive scarring of the liver. Because these beverages are popular, widely available, and inexpensive, they could have the potential to become important in the prevention of advanced liver disease.
        "Over the past decades, we gradually deviated towards more unhealthy habits, including a sedentary lifestyle, decreased physical activity, and consumption of a 'Happy Diet'," explains lead author Louise J. M. Alferink, MD, of the Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands, "This Happy Diet, also known as the Western diet, is typically rich in unhealthy foods including processed foods lacking nutrients and artificial sugars. This has led not only to an obesity epidemic, but also to a rapid increase in the prevalence of non-alcoholic fatty liver disease (NAFLD), which is due to extensive accumulation of fat in the liver and resembles alcoholic liver disease in people who do not exceed two drinks a day of alcohol. In this context, examining accessible and inexpensive lifestyle strategies that have potential health benefits, such as coffee and tea consumption, is a viable approach to finding ways to halt the rapid increase of liver disease in developed countries."
        Sarwa Darwish Murad, MD, PhD, principal investigator of the study and hepatologist at the Erasmus MC University Medical Center, continues "There is quite some epidemiological, but also experimental data suggesting that coffee has health benefits on liver enzyme elevations, viral hepatitis, NAFLD, cirrhosis, and liver cancer. Beyond the liver, coffee has been demonstrated to be inversely associated with overall mortality in the general population. The exact mechanism is unknown but it is thought that coffee exerts anti-oxidant effects. We were curious to find out whether coffee consumption would have a similar effect on liver stiffness measurements in individuals without chronic liver disease."
        Data was gathered on 2,424 participants of the Rotterdam study, a large population-based cohort study including participants 45 years or older living in a suburb of Rotterdam, The Netherlands. All participants underwent an extensive physical work-up, including data collection for anthropometrics, blood sampling, hepatological imaging using abdominal ultrasound and Fibroscan®, which quantitatively measures liver stiffness. In addition, they completed an externally validated 389-item Food Frequency Questionnaire, which included detailed information on coffee and tea consumption.
        Coffee and overall tea consumption was divided into three categories: none, moderate (>0-3 cups per day), and frequent (?3). Tea consumption was categorized by herbal, green, or black tea and further into none (0) or any (>0) consumption.
        Investigators found that frequent coffee consumption was significantly associated with lower odds of high liver stiffness values (?8 kPa as proxy for liver fibrosis), i.e. less scarring of the liver, independent of lifestyle, metabolic, and environmental traits. When they looked at the whole range of liver stiffness values, they found that both frequent coffee and any herbal tea consumption, even in small amounts, were significantly associated with lower liver stiffness values. Finally, while no direct association was found between either coffee or tea and the presence of fat accumulation in the liver (NAFLD) per se, the effect of coffee on lowering the liver stiffness was significant in both the group with and without liver fat. The authors therefore concluded that frequent coffee and herbal tea seem to have beneficial effects on preventing liver scarring even before overt liver disease has developed.
        However, some caution in the interpretation of the results is necessary, as underlined in an accompanying editorial by Salvatore Petta, MD, PhD, of the Section of Gastroenterology and Hepatology, Di.Bi.M.I.S., University of Palermo, Italy, and Giulio Marchesini, MD, of the Department of Medical and Surgical Sciences (DIMEC), ''Alma Mater" University, Bologna, Italy., In fact, the study included only an elderly Caucasian population and there were few participants in the no-coffee or no-tea control groups, which limit a straightforward conclusion about the effect of coffee and tea on the liver.. The amount of tea consumed was generally low, making estimation of any protective effect difficult. Further, they note that more than 100 components are present in coffee and tea, including polyphenols and caffeine, which are contained in both beverages in very different and variable amounts.
        Hence, when asked "Should we add regular coffee and tea breaks to our daily life? Dr. Petta's and Dr. Marchesini's conclusion is, "Before this policy can be recommended, prospective studies are needed to identify the optimum amounts and the type(s) of coffee and tea leading to more favorable liver outcomes."

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StephenW

公开发布：2017年6月6日
喝咖啡或茶歇以保护你的肝脏

新研究表明，每天喝几杯可能会阻止肝硬化，报道“肝病学杂志”

爱思唯尔
图片

图像：使用鹿特丹研究的数据，研究人员确定，咖啡和草药茶的消费频繁与一般人群的肝硬化呈负相关，但与脂肪变性无关。查看更多

信用：L. Alferink和S. Darwish Murad

荷兰阿姆斯特丹，荷兰，2017年6月6日 - 慢性肝脏疾病是全球第十二个死因，许多这些疾病与不健康的生活方式相关。相反，健康的生活方式可以帮助预防或逆转肝脏疾病。肝相关死亡率与肝硬化的发展密切相关，肝硬化是进行性纤维化的最终后果，即由慢性炎症引起的肝脏瘢痕形成。根据“肝病学杂志”发表的一项新研究，研究人员发现，喝咖啡和凉茶可以防止肝纤维化，据估计肝硬化程度高，肝脏广泛瘢痕形成。因为这些饮料是流行的，广泛可用的和便宜的，它们可能具有在预防晚期肝病中变得重要的潜力。

“过去几十年来，我们逐渐偏向更不健康的习惯，包括久坐不动的生活方式，身体活动减少，以及”快乐饮食“的消费。”消化内科和肝病学系的主任作者Louise JM Alferink解释说，荷兰鹿特丹的伊拉斯姆斯大学医学中心“这个快乐的饮食，也被称为西方饮食，通常富含不健康的食物，包括缺乏营养素和人造糖的加工食品，这不仅导致了肥胖症的流行，非酒精性脂肪肝疾病（NAFLD）的发病率迅速增加，这是由于肝脏中脂肪的积累过多，酒精性肝病在酒精中不超过两杯饮料的情况下，在这种情况下，检查具有潜在健康益处的便利和便宜的生活方式策略，如咖啡和茶消费，是寻找方法来阻止快速增长的可行方法e发达国家的肝病。

伊拉斯姆斯大学医学中心研究和肝病学家主任研究员Sarwa Darwish Murad博士继续说道：“有相当一些流行病学，但也有实验数据表明，咖啡对肝酶升高，病毒性肝炎，NAFLD有健康益处，肝硬化和肝癌，除了肝脏外，咖啡已经被证明与一般人群的总体死亡率成反比关系，确切的机制是未知的，但认为咖啡发挥抗氧化作用，我们好奇地发现咖啡消费是否会对没有慢性肝病的个体的肝硬度测量产生类似的影响。“

在鹿特丹研究的2,424名参与者上收集了数据，这是一项大量的基于人群的队列研究，其中包括45岁或以上的居住在荷兰鹿特丹郊区的参与者。所有参与者进行了广泛的身体后处理，包括人体测量数据采集，血液采样，使用腹部超声的肝脏成像和Fibroscan®，定量测量肝硬化。此外，他们完成了一项外部验证的389项食品频率问卷，其中包括有关咖啡和茶叶消费的详细信息。

咖啡和茶叶总消费量分为三类：无，中等（> 0-3杯/天），频繁（？3）。茶叶消费由草本，绿茶或红茶分类，进一步分为无（0）或任何（> 0）消费。

调查人员发现，咖啡消耗频繁，与肝脏硬度值较高的几率（肝纤维化代谢为8kPa）相关，即与生活方式，代谢和环境性状无关的肝脏瘢痕形成较少。当他们观察肝脏僵硬度的全部范围时，他们发现，即使是少量的咖啡和任何草药茶消费量都与低胆固醇值显着相关。最后，虽然咖啡或茶之间没有发现直接关联，而且在肝脏（NAFLD）本身存在脂肪蓄积，但是在有和没有肝脏脂肪的组中，咖啡对降低肝硬度的影响是显着的。因此，作者得出结论，即使在明显的肝病发展之前，经常性的咖啡和草药茶似乎也有利于预防肝脏瘢痕。

然而，对于结果的解释，一些谨慎是必要的，正如在“胃肠病科”的Salvatore Petta，MD，PhD的随附社论中强调的那样

MP4

我有个问题，茶中的咖啡因含量和这有没关系
茶中主要作用成分是啥

StephenW

回复 MP4 的帖子

tea-polyphenols茶多酚.

道理不明,只是猜测. 可能是(anti-oxident)抗氧化剂.



Since caffeine alone does not seem to fully explain the beneficial effect of coffee, other components are proposed to contribute. Both coffee and tea contain a substantial amount of polyphenols, which have been suggested to promote hepatoprotective effects independent of caffeine.45
Animal studies showed that coffee-polyphenols, chlorogenic acid and tocopherols, attenuate obesity-related lipid accumulation in the liver46
and have antioxidant properties. Furthermore, experimental animal data
suggest that tea-polyphenols attenuate fibrosis, oxidative stress
and inflammation through pivotal inflammatory transcription factor47
and inhibition of hepatic stellate cell activation.48
In our population study, we could not explore the underlying mech-
anistic pathway responsible for the observed effects.
由于咖啡因本身似乎没有完全解释咖啡的有益效果，因此其他组分被提出贡献。 咖啡和茶都含有大量的多酚，这被认为可以促进独立于咖啡因的肝保护作用。
动物研究表明，咖啡多酚，绿原酸和生育酚减轻了肝脏中肥胖相关的脂质积累46
并具有抗氧化性能。 此外，实验动物数据
表明茶多酚减弱纤维化，氧化应激
并通过关键性炎症转录因子发炎
并抑制肝星状细胞的活化
在我们的人口研究中，我们无法探索底层的机制，
负责观察效果的主观途径。


Only few studies have assessed the effect of overall tea con-
sumption  on  liver  disease  and  these  show  inconsistent
results.18,37,39
Moreover, five large Asian studies specifically examined green tea consumption in relation to liver health,19,20
of which three found a significant beneficial association between
green tea and serum transaminases.21,22,40
However, this association was only seen in individuals consuming more than 700 ml
green tea per day. We could not detect a beneficial effect of green
tea in our study. This may partly be explained by our predominantly elderly Caucasian population, in which drinking green
tea is not customary, as reflected in the low consumption rate.
We speculate that the beneficial effects of tea could be dose-dependent and might only exert an independent effect on liver health when consumed above a certain threshold.

只有少数研究评估了整体茶叶的影响
对肝脏疾病的综述和这些显示不一致
results.18,37,39
此外，五大亚洲研究专门研究了与肝脏健康有关的绿茶消费量
其中三个发现了重要的有益关联
绿茶和血清转氨酶21,22,40
然而，这种关联仅在消耗超过700毫升的个体中被看到
绿茶每天 我们无法检测到绿色的有益效果
茶在我们学习。 这可能部分地由我们主要是老年白种人，其中饮用绿色解释
茶不习惯，反映在低消费率。
我们推测，茶的有益效果可能是剂量依赖性的，并且只有在超过某一阈值时才能对肝脏健康产生独立影响。