慢性乙型肝炎慢性肾脏病患病率：横断面调查。

StephenW

J Viral Hepat. 2017 Jun 5. doi: 10.1111/jvh.12733. [Epub ahead of print]
Prevalence of chronic kidney disease in patients with chronic hepatitis B: A cross-sectional survey.Ning L1, Lin W1, Hu X1, Rong F1, Liang X1, Wu Y1, Shen S1, Yu R1, Sun J1, Hou J1.
Author information
1State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

AbstractRenal safety is a major concern during long-term antiviral treatment for chronic hepatitis B (CHB). This study aimed to investigate the prevalence of chronic kidney disease (CKD) in patients with CHB that had been treated with antiviral therapy. This was a single center, cross-sectional study in a real-life cohort in which all patients received antiviral treatment. Serum creatinine-based equations from the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) were used to estimate the glomerular filtration rate (GFR). CKD was defined as an eGFR <60 mL/min/1.73 m² or a urinary albumin to creatinine ratio ≥ 3 mg/mmol (defined as albuminuria). Univariate and multivariate analyses were conducted to determine the risk factors of CKD.A total of 1985 patients were included in the analysis from February 2015 to December 2015. The mean age and median duration of antiviral treatment was 42.20 years and 17.05 months, respectively. The overall prevalence of CKD was 7.9% (157/1985), with 44 patients experiencing decreased renal function (eGFR less than 60 mL/min/1.73 m²) and 129 patients with albuminuria. Patients with cirrhosis had a higher prevalence of a decreased GFR (4.3% vs. 1.6%, P <0.001) and albuminuria (11.1% vs. 5.2%, P <0.001) than those without cirrhosis. In the multivariate analysis, hypertension (Odds Ratio [OR] 4.564, P<0.001), diabetes mellitus (OR 2.688, P<0.001) and cirrhosis (OR 1.918, P<0.001) were independent factors associated with the presence of CKD. CKD was a clinically significant comorbidity in patients with CHB. Special attention should be paid to cirrhotic patients and patients with the metabolic syndrome. This article is protected by copyright. All rights reserved.


This article is protected by copyright. All rights reserved.



KEYWORDS: Chronic hepatitis B; albuminuria; chronic kidney disease; renal function

PMID:28581186DOI:10.1111/jvh.12733

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StephenW

J病毒肝2017年6月5日。doi：10.1111 / jvh.12733。 [提前印刷]
慢性乙型肝炎慢性肾脏病患病率：横断面调查。
宁L1，林W1，胡X1，荣F1，梁X1，吴毅，沉S1，俞R1，孙继1，侯J 1。
作者信息

1
    广东省南方医科大学南方医院传染病病毒性肝炎病毒性肝炎研究重点实验室器官功能衰竭研究国家重点实验室。

抽象

慢性乙型肝炎（CHB）长期抗病毒治疗期间，肾脏安全是一个主要问题。本研究旨在调查用抗病毒治疗治疗的CHB患者慢性肾脏疾病（CKD）患病率。这是一个现代生活队列中的单中心横断面研究，其中所有患者都接受抗病毒治疗。使用慢性肾脏疾病流行病学协作（CKD-EPI）的基于血肌酐的方程来估计肾小球滤过率（GFR）。 CKD被定义为eGFR <60mL / min / 1.73m 2或尿白蛋白与肌酐比≥3mg/ mmol（定义为蛋白尿）。进行单变量和多变量分析以确定CKD的危险因素。从2015年2月至2015年12月，将1985年患者总数纳入分析。抗病毒治疗的平均年龄和中位数分别为42.20岁和17.05个月。 CKD的总体发病率为7.9％（157/1985），44例患者肾功能下降（eGFR小于60 mL / min / 1.73平方米）和129例白蛋白尿患者。与没有肝硬化的患者相比，肝硬化患者的流行率更高（4.3％vs 1.6％，P <0.001）和白蛋白尿（11.1％vs. 5.2％，P <0.001）。在多变量分析中，高血压（OR值为4.564，P <0.001），糖尿病（OR 2.688，P <0.001）和肝硬化（OR 1.918，P <0.001）是与CKD存在相关的独立因素。慢性阻塞性肺疾病患者CHB患者临床意义重大。应特别注意肝硬化患者和代谢综合征患者。本文受版权保护。版权所有。

本文受版权保护。版权所有。
关键词：

慢性乙型肝炎蛋白尿;慢性肾病;肾功能

结论：
    28581186
DOI：
    10.1111 / jvh.12733