慢性乙型肝炎携带者的多民族队列中的周围细胞因子发光与

StephenW

Am J Reprod Immunol. 2017 May 19. doi: 10.1111/aji.12707. [Epub ahead of print]
Peripartum cytokine flares in a multiethnic cohort of chronic hepatitis B carriers does not correlate with hepatitis B virus suppression or increased risk of liver disease.
Joshi SS1,2, Wong D2, Castillo E3, Swain MG1, Coffin CS1,2.
Author information

1    Calgary Liver Unit, Division of Gastroenterology and Hepatology, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
2    Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
3    Section of Maternal Fetal Medicine, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Abstract
PROBLEM:

In chronic hepatitis B (CHB) carriers, alanine transaminase (ALT) flares are common in the peripartum period. There are limited data on immunological changes of pregnancy in CHB. We hypothesize that in pregnant CHB carriers, the Th1/Th2 cytokine ratio is altered resulting in changes in biochemical/virological and liver fibrosis markers.
STUDY METHODS:

Serum from 38 pregnant/post-partum CHB carriers (median age 32 years, 53% Asian, 8 HBeAg+ ) was tested for HBV DNA, quantitative HBV surface antigen, ALT and liver fibrosis by transient elastography (TE). Serum cytokines were analyzed using a Luminex assay.
RESULTS:

Untreated CHB cases had mild ALT flares post-partum, but showed normal TE, and no change in viral markers despite increased Th1 cytokines compared to healthy controls (P<.05).
CONCLUSION:

CHB carriers show increased Th1 cytokines in the peripartum period albeit with no effect on viral load or liver disease suggesting an aborted antiviral immune response.

© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
KEYWORDS:

CHB-pregnancy; Th1-cytokines; hepatitis B virus; liver stiffness measurement

PMID:
    28544232
DOI:
    10.1111/aji.12707

StephenW

Am J Reprod Immunol。 2017年5月19. doi：10.1111 / aji.12707。 [提前印刷]
慢性乙型肝炎携带者的多民族队列中的周围细胞因子发光与乙型肝炎病毒抑制或肝脏疾病风险增加无关。
Joshi SS1,2，Wong D2，Castillo E3，Swain MG1，Coffin CS1,2。
作者信息

加拿大卡尔加里卡尔加里大学卡姆加里大学医学院胃肠病与肝病学系卡尔加里肝单位1名。
2加拿大卡尔加里卡尔加里大学康明医学院微生物学与免疫学与传染病科。
3加拿大卡尔加里卡尔加里大学医学院孕妇胎儿医学系。

抽象
问题：

在慢性乙型肝炎（CHB）携带者中，丙氨酸转氨酶（ALT）耀斑在围产期是常见的。 CHB中妊娠免疫学变化数据有限。我们假设在怀孕的CHB携带者中，Th1 / Th2细胞因子比例发生变化，导致生化/病毒学和肝纤维化标志物的变化。
研究方法：

通过瞬态弹性成像（TE）检测38例怀孕/产后CHB携带者（中位年龄32岁，53％亚洲人，8例HBeAg +）的血清HBV DNA，定量HBV表面抗原，ALT和肝纤维化。使用Luminex检测法分析血清细胞因子。
结果：

未治疗的CHB病例产后出现轻度ALT耀斑，但呈现正常TE，尽管Th1细胞因子与健康对照组相比，病毒标志物无变化（P <0.05）。
结论：

CHB载体在周围产生Th1细胞因子增加，尽管对病毒载量或肝脏疾病没有影响，表明中止了抗病毒免疫反应。

©2017 John Wiley＆Sons A / S。由John Wiley＆Sons Ltd.出版
关键词：

CHB怀孕;中Th1细胞因子;乙型肝炎病毒;肝硬度测量

结论：
    28544232
DOI：
    10.1111 / aji.12707