妊娠结局超过5000例患有病毒性肝炎的妇女：在瑞典的基于人

StephenW

Eur J Epidemiol. 2017 May 26. doi: 10.1007/s10654-017-0261-z. [Epub ahead of print]
Pregnancy outcome in more than 5000 births to women with viral hepatitis: a population-based cohort study in Sweden.Stokkeland K1,2, Ludvigsson JF3,4,5, Hultcrantz R6,7, Ekbom A8, Höijer J9, Bottai M9, Stephansson O8,10.
Author information
1Department of Medicine, Visby Hospital, St Görans Str. 8, 621 84, Visby, Sweden. [email protected].2Department of Medicine, Gastroenterology and Hepatology Unit, Karolinska Institutet, Stockholm, Sweden. [email protected].3Department of Pediatrics, Örebro University Hospital, Örebro, Sweden.4Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.5Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK.6Department of Medicine, Gastroenterology and Hepatology Unit, Karolinska Institutet, Stockholm, Sweden.7Division of Hepatology, Karolinska Hospital, Stockholm, Sweden.8Department of Medicine, Solna, Clinical Epidemiology Unit, Karolinska Hospital and Institutet, Stockholm, Sweden.9Unit of Biostatistics, IMM, Karolinska Institutet, Stockholm, Sweden.10Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

AbstractPrevious studies have shown inconsistent results with respect to hepatitis B (HBV), hepatitis C (HCV) and pregnancy outcome. The aim of this study was to investigate pregnancy outcome in women with HBV or HCV. In a nationwide cohort of births between 2001 and 2011 we investigated the risks of adverse pregnancy outcomes in 2990 births to women with HBV and 2056 births to women with HCV using data from Swedish healthcare registries. Births to women without HBV (n = 1090 979), and births without HCV (n = 1091 913) served as population controls. Crude and adjusted relative risks (aRR) were calculated using Poisson regression analysis. Women with HCV were more likely to smoke (46.7 vs. 8.0%) and to have alcohol dependence (18.9 vs. 1.3%) compared with population controls. Most women with HBV were born in non-Nordic countries (91.9%). Maternal HCV was associated with a decreased risk of preeclampsia (aRR: 0.39, 95% CI: 0.24-0.64), but an increased risk of preterm birth (aRR: 1.32, 95% CI: 1.08-1.60) and late neonatal death (7-27 days: aRR: 3.79, 95% CI: 1.07-13.39) Preterm birth were also more common in mothers with HBV, aRR: 1.21 (95% CI: 1.02-1.45). Both HBV and HCV are risk factors for preterm birth, while HCV seems to be associated with a decreased risk for preeclampsia. Future studies should corroborate these findings.


KEYWORDS: Late neonatal death; Preeclampsia; Pregnancy outcomes; Preterm birth

PMID:28550648DOI:10.1007/s10654-017-0261-z

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StephenW

Eur J Epidemiol。 2017年5月26日。doi：10.1007 / s10654-017-0261-z。 [提前印刷]
妊娠结局超过5000例患有病毒性肝炎的妇女：在瑞典的基于人群的队列研究。
Stokkeland K1,2，Ludvigsson JF3,4,5，Hultcrantz R6,7，Ekbom A8，HöijerJ9，Bottai M9，Stephansson O8,10。
作者信息

1
    医学系，维斯比医院，StGöransStr。 8，621 84，Visby，Sweden。 [email protected]。
2
    瑞典斯德哥尔摩卡罗林斯卡研究所医学部消化内科和肝病科。 [email protected]。
3
    瑞典ÖrebroÖrebro大学医院儿科系。
4
    瑞典斯德哥尔摩Karolinska机构医学流行病学和生物统计学系。
五
    英国诺丁汉诺丁汉大学流行病与公共卫生学系。
6
    瑞典斯德哥尔摩卡罗林斯卡研究所医学部消化内科和肝病科。
7
    瑞典斯德哥尔摩卡罗林斯卡医院肝脏科。
8
    瑞典斯德哥尔摩卡罗林斯卡医院和研究所临床流行病学系Solna医学系。
9
    生物统计学单位IMM，Karolinska Institutet，斯德哥尔摩，瑞典。
10
    瑞典斯德哥尔摩卡罗林斯卡研究所妇女和儿童健康部。

抽象

以前的研究显示乙型肝炎（HBV），丙型肝炎（HCV）和妊娠结局方面的结果不一致。本研究的目的是调查HBV或HCV女性的怀孕结果。在2001年至2011年的全国出生队列中，我们调查了使用瑞典医疗保健注册管理机构数据的2990例出生HBV患者和2056例出生HCV患者的不良妊娠结局的风险。没有HBV（n = 1090 979）的妇女和没有HCV的出生（n = 1091 913）作为人口控制。使用泊松回归分析计算原始和调整后的相对风险（aRR）。与人群对照相比，HCV患者更有可能吸烟（46.7％vs. 8.0％），酒精依赖（18.9％vs. 1.3％）。大多数HBV患者出生于非北欧国家（91.9％）。母亲HCV与先兆子痫风险降低有关（aRR：0.39,95％CI：0.24-0.64），但早产风险增加（aRR：1.32,95％CI：1.08-1.60）和晚期新生儿死亡（7例-27天：aRR：3.79,95％CI：1.07-13.39）早产儿也较常见于母亲HBV，aRR：1.21（95％CI：1.02-1.45）。 HBV和HCV都是早产的危险因素，而HCV似乎与先兆子痫风险降低有关。未来的研究应证实这些发现。
关键词：

新生儿晚期死亡;先兆子痫;妊娠结局早产

结论：
    28550648
DOI：
    10.1007 / s10654-017-0261-Z