更高的BMI对乙型肝炎和C型肝细胞癌的影响

StephenW

Langenbecks Arch Surg. 2017 May 22. doi: 10.1007/s00423-017-1589-2. [Epub ahead of print]
Influence of higher BMI for hepatitis B- and C-related hepatocellular carcinomas.
Hashimoto M1, Tashiro H2, Kobayashi T1, Kuroda S1, Hamaoka M1, Ohdan H1.
Author information

1    Department of Gastroenterological and Transplant Surgery, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8557, Japan.
2    Department of Surgery, Kure Medical Center, National Hospital Organization, 3-1 Aoyama, Kure City, Hiroshima, 737-0023, Japan. [email protected].

Abstract
PURPOSE:

Although obesity is associated with hepatocellular carcinoma (HCC) development, its impact on the surgical outcomes of patients with hepatitis B virus (HBV)-and hepatitis C virus (HCV)-related HCC remains unclear.
METHODS:

We retrospectively analyzed 714 patients with HCC who underwent curative hepatectomy. Among them, the HBV-related HCC group (n = 125) and HCV-related HCC group (n = 426) were subdivided according to the presence of body mass index (BMI) ≥ 25 kg/m2. The surgical outcomes were compared.
RESULTS:

The 5-year overall survival rate after hepatectomy in the HBV-related HCC group was significantly better than that in the HCV-related HCC group. The 5-year overall survival rates of the HBV-related HCC with and without BMI ≥ 25 kg/m2 groups were 65 and 85%, respectively. The 5-year overall survival rates in the HCV-related HCC with and without BMI ≥ 25 kg/m2 groups were 75 and 65%, respectively. The HBV-related HCC with BMI ≥ 25 kg/m2 groups had a significantly worse prognosis than the HBV-related HCC without BMI ≥ 25 kg/m2 groups, while the HCV-related HCC with BMI ≥ 25 kg/m2 groups had a significantly better prognosis than the HCV-related HCC without BMI ≥ 25 kg/m2 groups. Multivariate analysis revealed that BMI ≥ 25 kg/m2 was the positive and negative prognostic factor for the surgical outcomes of patients with HBV- and HCV-related HCC, respectively.
CONCLUSIONS:

BMI ≥ 25 kg/m2 negatively affected the surgical outcomes of patients with HBV-related HCC and positively affected those of patients with HCV-related HCC.
KEYWORDS:

Body mass index (BMI); Overweight; Patients with HBV-related HCC; Patients with HCV-related HCC; Prognosis

PMID:
    28534136
DOI:
    10.1007/s00423-017-1589-2

StephenW

Langenbecks Arch Surg。 2017年5月22日。doi：10.1007 / s00423-017-1589-2。 [提前印刷]
更高的BMI对乙型肝炎和C型肝细胞癌的影响。
桥本M1，Tashiro H2，小林T1，黑田S1，Hamaoka M1，Ohdan H1。
作者信息

1
    广岛大学医院胃肠外科手术系，日本南沙734-8557，广岛市南口1-2-3号。
2
    日本737-0023日本广岛市Kure市3-1山国立医院组织Kure医学中心外科。 [email protected]。

抽象
目的：

虽然肥胖与肝细胞癌（HCC）发展相关，但其对乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）相关HCC患者手术结局的影响仍不清楚。
方法：

回顾性分析了714例接受肝切除术的肝癌患者。其中，HBV相关HCC组（n = 125）和HCV相关HCC组（n = 426）根据体重指数（BMI）≥25kg / m2的存在细分。比较手术结果。
结果：

HBV相关HCC组肝切除术后5年总生存率明显优于HCV相关HCC组。 BMI≥25 kg / m2组HBV相关性肝癌5年总生存率分别为65％和85％。 B型≥25kg / m2组HCV相关性肝癌5年总生存率分别为75％和65％。 BMI≥25 kg / m2的HBV相关HCC预后与HBV相关性HCC无明显差异（BMI≥25kg / m2），而BMI≥25 kg / m2组的HCV相关HCC组显着性差异比没有BMI≥25 kg / m2组的HCV相关HCC预后更好。多变量分析显示，BMI≥25 kg / m2分别是HBV和HCV相关HCC患者手术结果的阳性和阴性预后因素。
结论：

BMI≥25kg / m2对HBV相关HCC患者的手术结果产生不利影响，对HCV相关HCC患者的BMI≥25kg / m2有显着影响。
关键词：

体重指数（BMI）;超重; HBV相关HCC患者; HCV相关HCC患者;预测

结论：
    28534136
DOI：
    10.1007 / s00423-017-1589-2