了解在乙型肝炎病毒治疗期间观察到的复杂模式。

StephenW

Viruses. 2017 May 19;9(5). pii: E117. doi: 10.3390/v9050117.
Understanding the Complex Patterns Observed during Hepatitis B Virus Therapy.
Carracedo Rodriguez A1, Chung M2, Ciupe SM3.
Author information

1    Department of Mathematics, Virginia Tech, 460 McBryde Hall, Blacksburg, VA 24060, USA. [email protected].
2    Department of Mathematics, Virginia Tech, 460 McBryde Hall, Blacksburg, VA 24060, USA. [email protected].
3    Department of Mathematics, Virginia Tech, 460 McBryde Hall, Blacksburg, VA 24060, USA. [email protected].

Abstract

Data from human clinical trials have shown that the hepatitis B virus (HBV) follows complex profiles, such as bi-phasic, tri-phasic, stepwise decay and rebound. We utilized a deterministic model of HBV kinetics following antiviral therapy to uncover the mechanistic interactions behind HBV dynamics. Analytical investigation of the model was used to separate the parameter space describing virus decay and rebound. Monte Carlo sampling of the parameter space was used to determine the virological, pharmacological and immunological factors that separate the bi-phasic and tri-phasic virus profiles. We found that the level of liver infection at the start of therapy best separates the decay patterns. Moreover, drug efficacy, ratio between division of uninfected and infected cells, and the strength of cytotoxic immune response are important in assessing the amount of liver damage experienced over time and in quantifying the duration of therapy leading to virus resolution in each of the observed profiles.
KEYWORDS:

Monte Carlo; drug therapy; hepatitis B virus (HBV); virus kinetics

PMID:
    28534812
DOI:
    10.3390/v9050117

StephenW

病毒。 2017年5月19日; 9（5）。皮亚：E117。 Doi：10.3390 / v9050117。
了解在乙型肝炎病毒治疗期间观察到的复杂模式。
Carracedo Rodriguez A1，Chung M2，Ciupe SM3。
作者信息

1弗吉尼亚理工大学数学系460 McBryde Hall，Blacksburg，VA 24060，USA。 [email protected]。
2
弗吉尼亚理工大学数学系460 McBryde Hall，Blacksburg，VA 24060，USA。 [email protected]。
3
弗吉尼亚理工大学数学系460 McBryde Hall，Blacksburg，VA 24060，USA。 [email protected]。

抽象

从人类临床试验已经显示，乙型肝炎病毒（HBV）遵循复杂的分布，如双相，三相，逐步衰变和反弹。我们使用HBV k的确定性模型预测抗病毒治疗以揭示机械相互作用在该模型的控制下，用于分离参数空间调节的病毒衰减和反弹。参数空间的蒙特卡罗取样用于确定分离双相和三相病毒相容性的病毒学，药理学和免疫学因素。我们发现，治疗开始时肝脏感染的水平最好分离衰老模式。此外，药物功效，未感染细胞和感染细胞分裂之间的比例以及细胞毒性免疫应答的强度对于评估随时间经历的肝脏损伤的量以及量化在每个观察到的细胞中导致病毒解离的治疗持续时间是重要的。
关键词：

蒙特卡洛;药物治疗;乙型肝炎病毒（HBV）

结论：
28534812
DOI：
10.3390 / v9050117