吸烟与肝纤维化的严重程度相关，但与非酒精性脂肪性肝病

StephenW

Smoking is associated with severity of liver fibrosis but not with histological severity in nonalcoholic fatty liver disease. Results from a cross-sectional study
Isabelle D Munsterman, Mark M Smits, Rene Andriessen, Carin M J van Nieuwkerk, Elisabeth Bloemena, Chris J J Mulder, show all
Pages 1-5 | Received 10 Feb 2017, Accepted 28 Mar 2017, Published online: 27 Apr 2017

    Download citation http://dx.doi.org/10.1080/00365521.2017.1315169


Abstract

Objectives: To assess the influence of smoking on histological disease severity and fibrosis in real-world NAFLD patients.

Material and methods: Consecutive NAFLD patients were identified with liver biopsies performed between 2008 and 2015. Characteristics such as smoking status and total number of pack years were collected. Biopsies were revised and BRUNT fibrosis and NAFLD activity score (NAS) determined. Patients with a high NAS (≥5) were compared to patients with a low NAS (<5) and with advanced fibrosis (stage 3–4) to patients with no-early fibrosis (stage 0–2). Patients with a history of smoking (current or past smoker) were defined ever smokers.

Results: Fifty-six patients were included (mean age 49 ± 14.3, 68.9% males and 39.3% history of smoking). Ever smokers had a higher fibrosis score than never smokers; two (IQR 0–3) versus one (IQR 1–1.5) (p = .040). Patients with advanced fibrosis smoked significantly more pack years than patients with no-early fibrosis; 10.6 (IQR 0–25.8) versus 0 (IQR 0–7) (p = .011). There is a weak to moderate correlation between fibrosis stage and number of pack years (Spearman’s Rho = 0.341, p = .012). There was no difference in NAS between never and ever smokers; 2.8 ± 1.5 versus 3.3 ± 1.4 (p = .205). Patients with NAS <5 had a median number of pack years of 0 (IQR 0–9) versus a median of 10.3 pack years (IQR 0–24) in patients with NAS ≥5 (p = .127).

Conclusion: Smoking is associated with severity of NAFLD-related liver fibrosis but not with histological disease severity. This supports the recommendation to cease smoking for NAFLD patients.
Keywords: NAFLD, smoking, NASH, liver fibrosis, pathohistology

StephenW

吸烟与肝纤维化的严重程度相关，但与非酒精性脂肪性肝病的组织学严重程度无关。横断面研究的结果
Isabelle D Munsterman，Mark M Smits，Rene Andriessen，Carin M J van Nieuwkerk，Elisabeth Bloemena，Chris J J Mulder，显示全部
第1-5页|收到2017年2月10日，接受日期：2017年3月28日，在线发布：2017年4月27日

    下载引文http://dx.doi.org/10.1080/00365521.2017.1315169


抽象

目的：评估吸烟对真实NAFLD患者组织病变严重程度和纤维化的影响。

材料与方法：连续NAFLD患者在2008年至2015年期间进行了肝活组织检查，收集了吸烟状况和总包数等特征。修复活组织检查，确定BRUNT纤维化和NAFLD活性评分（NAS）。将具有高NAS（≥5）的患者与无早期纤维化患者（0-2级）相比，具有低NAS（<5）和晚期纤维化（3-4期）的患者。具有吸烟史（目前或过去吸烟者）的患者被定义为吸烟者。

结果：56例患者（平均年龄49±14.3岁，男性为68.9％，吸烟史为39.3％）。过去吸烟者的纤维化评分高于不吸烟者;两个（IQR 0-3）与一个（IQR 1-1.5）（p = 0.040）。晚期纤维化患者吸烟明显多于无早期纤维化的患者; 10.6（IQR 0-25.8）与0（IQR 0-7）（p = 0.011）。纤维化阶段与包装年数之间存在弱至中度的相关性（Spearman Rho = 0.341，p = 0.012）。从来没有吸烟者，NAS之间没有差别; 2.8±1.5对3.3±1.4（p = .205）。 NAS <5的患者中位数为0（IQR 0-9），而NAS≥5的患者中位数为10.3包年（IQR 0-24）（p = .127）。

结论：吸烟与NAFLD相关肝纤维化的严重程度相关，但与组织学疾病严重程度无关。这支持NAFLD患者戒烟的建议。
关键词：NAFLD，吸烟，NASH，肝纤维化，病理组织学

雁过留声

雁过留声

rxsm

就是戒不了啊