HBsAg在慢性乙型肝炎病毒感染各阶段的合成和分泌可能存在不

StephenW

Med Sci Monit. 2017 Mar 21;23:1385-1393.
Different Mechanisms May Exist for HBsAg Synthesis and Secretion During Various Phases of Chronic Hepatitis B Virus Infection.
Li Y1, Cai Q2, Xie Q2, Zhang Y2, Meng X1, Zhang Z2.
Author information

1    Department of General Surgery, The 1st Affiliated Hospital of Anhui Medical University, Anhui, Hefei, China (mainland).
2    Department of Infectious Diseases, The 1st Affiliated Hospital of Anhui Medical University, Anhui, Hefei, China (mainland).

Abstract

BACKGROUND The aim of this study was to characterize the expression and secretion of hepatitis B surface-antigen (HBsAg) in the hepatocytes of hepatitis B virus (HBV)-infected patients at different phases of infection; as such, the association of intrahepatic HBsAg expression with virological markers and the histological characteristics were analyzed. MATERIAL AND METHODS 302 chronic HBV infection patients who had not received antiviral therapy were stratified by HBeAg status. The proportion of HBsAg-positive cells was used as an indicator for HBsAg expression level. RESULTS In HBeAg-positive patients, there was a significant correlation between serum HBsAg and serum HBV DNA levels (r=0.569, p<0.001). Intrahepatic HBsAg expression and serum HBsAg level in HBeAg-positive patients were higher than those in HBeAg-negative patients (p=0.002 and p<0.001, respectively). A significant correlation between serum HBsAg level and intrahepatic HBsAg expression was found in HBeAg-negative patients (r=0.377, p<0.001), but not in HBeAg-positive patients (r=0.051, p=0.557). Very interestingly, the correlation between serum HBsAg level and HBsAg expression in hepatocytes gradually increased along with disease progression through the immune-tolerant, immune-clearance, inactive, and recovery phases of HBV infection (r=-0.184, 0.068, 0.492, and 0.575; and p=0,238, 0,722, 0.012, and 0.002, respectively). CONCLUSIONS Different mechanisms may be involved in HBsAg synthesis and secretion in different phases of chronic HBV infection.

PMID:
    28321112

StephenW

Med Sci Monit。 2017年3月21日; 23：1385-1393。
HBsAg在慢性乙型肝炎病毒感染各阶段的合成和分泌可能存在不同的机制。
李Y1，蔡Q2，谢Q2，张Y2，孟X1，张Z2。
作者信息

1安徽医科大学附属第一医院普外外科，安徽合肥，中国大陆。
2安徽医科大学附属第一医院感染科，安徽合肥，中国（大陆）。

抽象

背景技术本研究的目的是描述不同感染阶段乙型肝炎病毒（HBV）感染患者肝细胞乙型肝炎表面抗原（HBsAg）的表达和分泌情况;因此，分析肝内HBsAg表达与病毒学标志物的关联和组织学特征。材料与方法302例未接受抗病毒治疗的慢性HBV感染患者按HBeAg状态分层。 HBsAg阳性细胞的比例用作HBsAg表达水平的指标。结果HBeAg阳性患者血清HBsAg与血清HBV DNA水平呈显着相关（r = 0.569，p <0.001）。 HBeAg阳性患者肝内HBsAg表达和血清HBsAg水平高于HBeAg阴性患者（p = 0.002，p <0.001）。 HBeAg阴性患者血清HBsAg水平与肝内HBsAg水平之间存在显着相关性（r = 0.377，p <0.001），而HBeAg阳性患者血清HBsAg水平与肝内HBsAg水平呈显着正相关（r = 0.051，p = 0.557）。非常有趣的是，肝细胞中血清HBsAg水平和HBsAg表达之间的相关性随着HBV感染的免疫耐受，免疫清除，无活性和恢复期的疾病进展而逐渐增加（r = -0.184,0.068,0.492,0.575 ;和p = 0,238,0,722,0.012和0.002）。结论慢性HBV感染不同阶段的HBsAg合成和分泌可能涉及不同的机制。

PMID：
    28321112