咖啡消耗与慢性肝病风险降低有关

StephenW

Coffee consumption associated with reduced risk for chronic liver disease

Setiawan VW, et al. Clin Gastroenterol Hepatol. 2017;doi:10.1016/j.cgh.2017.02.038.
March 14, 2017

Recent study data revealed an association between coffee consumption and a reduced risk for developing chronic liver disease, particularly in non-alcoholic fatty liver disease, alcoholic liver disease and chronic hepatitis C.


“Coffee consumption has been inversely associated with [chronic liver disease (CLD)] severity, but studies were mainly conducted in [chronic hepatitis C (CHC)] while fewer studies have been done in other etiologies,” Veronica Wendy Setiawan, PhD, of the department of preventive medicine and the Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, and colleagues wrote. “Our findings support data from studies showing the effect of coffee on liver enzyme reduction and the association of increased coffee consumption with reduced histological activity, in particular fibrosis in CHC.”

The study comprised 5,385 patients from the Multiethnic Cohort study. The patients had enrolled in the Medicare fee-for-service program and had completed questionnaires on coffee intake and confounders.

Patient diagnoses included ALD (n = 1,112), NALFD (n = 2,786), CHC (n = 606), chronic hepatitis B (n = 165), cryptogenic cirrhosis (n = 359) or other liver-related disease (n = 357). Mean patient age was 61 years, 44% of the patients were men, and ethnicities included Japanese-American (38%), white (23%), Latino (22%), African-American (12%) and Native Hawaiian (5%).

Researchers categorized coffee intake as less than one cup daily, one cup daily, two to three cups daily and four or more cups daily. Patients were matched with controls by age, sex, ethnicity and length of fee-for-service enrollment.

Data showed an association between coffee consumption and a reduced risk for ALD (P = .0015) and CHC (P = .0241), and specifically ALD (P < .0001) and CHC (P = .0215) with cirrhosis. The results further showed an association between coffee consumption and NALFD in both cirrhosis (P = .0484) and non-cirrhosis cases (P = .0018). Researchers found no evidence that coffee association varied by ethnicity. There was no association found between coffee drinking and CLD or cirrhosis due to other etiologies.

“Our data also suggest a possible effect of coffee intake on the fibrosis process in ALD and CHC and an effect of coffee on multiple pathways in NAFLD, possibly including inflammatory, steatotic and fibrotic processes. The effect of coffee on fibrosis may be mediated by adenosine receptors. It is possible that coffee constituents have a direct effect on steatosis or steatohepatitis pathways,” the researchers wrote. “We propose that randomized controlled trials should be entertained, in particular in NAFLD patients where coffee consumption seems to affect the entire disease process and no treatments are currently available.” – by Talitha Bennett

Disclosure: The researchers report no relevant financial disclosures.

StephenW

咖啡消耗与慢性肝病风险降低有关

Setiawan VW，et al。 Clin Gastroenterol Hepatol。 2017; doi：10.1016 / j.cgh.2017.02.038。
2017年3月14日

最近的研究数据显示，咖啡消耗与发生慢性肝病的风险降低之间有关联，特别是在非酒精性脂肪肝疾病，酒精性肝病和慢性丙型肝炎中。


“咖啡消费量与[慢性肝病（CLD）]严重程度呈负相关，但研究主要是在[慢性丙型肝炎（CHC）]中进行，而其他病因学研究较少，”Veronica Wendy Setiawan博士预防医学部和诺里斯综合癌症中心，凯克医学院，南加州大学洛杉矶分校和同事写道。 “我们的研究结果支持来自研究的数据，显示咖啡对肝脏酶减少的影响和增加的咖啡消耗与减少的组织学活性，特别是CHC中的纤维化的关联。

该研究包括来自多种族队列研究的5,385例患者。这些患者已参加了医疗保险费用服务计划，并完成了关于咖啡摄入和混杂因素的调查问卷。

患者诊断包括ALD（n = 1,112），NALFD（n = 2,786），CHC（n = 606），慢性乙型肝炎（n = 165），隐源性肝硬化（n = 359）或其他肝脏相关疾病）。平均病人年龄为61岁，44％的病人为男性，种族包括日裔美国人（38％），白人（23％），拉丁美洲人（22％），非洲裔美国人（12％）和夏威夷原住民％）。

研究人员将咖啡摄入量分类为每天少于一杯，每天一杯，每天两至三杯，每天四杯或更多杯。患者通过年龄，性别，种族和服务入学时间长度与对照进行匹配。

数据显示咖啡消耗与ALD（P = .0015）和CHC（P = 0.0241），特别是ALD（P <0.0001）和CHC（P = 0.0215）与肝硬化的风险降低之间的关联。结果进一步显示咖啡消耗和NALFD在肝硬化（P = .0484）和非肝硬化病例（P = .0018）两者之间的关联。研究人员没有发现咖啡联想因种族而异的证据。由于其他病因，咖啡饮用与CLD或肝硬化之间没有关联。

“我们的数据还表明咖啡摄入对ALD和CHC的纤维化过程的可能影响和咖啡对NAFLD多种途径的影响，可能包括炎症，脂肪变性和纤维化过程。咖啡对纤维化的影响可以由腺苷受体介导。咖啡成分可能对脂肪变性或脂肪性肝炎通路有直接影响，“研究人员写道。 “我们建议应该接受随机对照试验，特别是在NAFLD患者中，咖啡消耗似乎影响整个疾病过程，目前没有治疗方法。” - Talitha Bennett

披露：研究人员报告没有相关的财务披露。

tacolynn

就是说喝咖啡对乙肝没什么帮助了

StephenW

回复 tacolynn 的帖子

不是, 喝咖啡减少发炎(肝脏酶),纤维化, 和非酒精性脂肪肝.

csfluke

回复 tacolynn 的帖子

不是，喝咖啡可以预防肝硬化，不过咖啡对肾不好，不然我去年考虑过喝咖啡的

tacolynn

回复 csfluke 的帖子

我老公一直喝咖啡的，发病之前喝速溶咖啡，喝了有10年。发病以后就开始喝现煮咖啡，也有快2年了，肾功能一直都挺好的。

csfluke

回复 tacolynn 的帖子

咖啡不伤肾，但是有肾病的就不适合喝了，我去年不是肾功能损伤嘛

cgyok

自磨咖啡，又得喝起来，咖啡机闲置一年了