HBV相关肝移植患者HBcrAg与HBV再感染的关系

StephenW

Journal of Gastroenterology

March 2017, Volume 52, Issue 3,                        pp 366–375

The relationship between HBcrAg and HBV reinfection in HBV related post-liver transplantation patients

• Authors
• Authors and affiliations
  
  

• Ayako Urabe
• Michio Imamura
• Masataka Tsuge
• Hiromi Kan
• Hatsue Fujino
• Takayuki Fukuhara
• Keiichi Masaki
• Tomoki Kobayashi
• Atsushi Ono
• Takashi Nakahara
• Tomokazu Kawaoka
• Akira Hiramatsu
• Yoshiiku Kawakami
• Hiroshi Aikata
• Clair Nelson Hayes
• 
  

• Ayako Urabe
  
  • 1
    
• Michio Imamura
  
  • 1
    
• Masataka Tsuge
  
  • 1
    
• Hiromi Kan
  
  • 1
    
• Hatsue Fujino
  
  • 1
    
• Takayuki Fukuhara
  
  • 1
    
• Keiichi Masaki
  
  • 1
    
• Tomoki Kobayashi
  
  • 1
    
• Atsushi Ono
  
  • 1
    
• Takashi Nakahara
  
  • 1
    
• Tomokazu Kawaoka
  
  • 1
    
• Akira Hiramatsu
  
  • 1
    
• Yoshiiku Kawakami
  
  • 1
    
• Hiroshi Aikata
  
  • 1
    
• Clair Nelson Hayes
  
  • 1
    
• Noboru Maki
  
  • 2
    
• Hideaki Ohdan
  
  • 3
    
• Kazuaki Chayama
  
  • 1
    
  Email author

• 1.Department of Gastroenterology and Metabolism, Applied Life ScienceInstitute of Biomedical and Health Science, Hiroshima University, Hiroshima UniversityHiroshimaJapan
• 2.Advanced Life Science Institute, Inc.WakoJapan
• 3.Division of Frontier Medical Science, Department of Surgery, Programs for Biomedical ResearchGraduate School of Biomedical Science, Hiroshima UniversityHiroshimaJapan
  

Original Article—Liver, Pancreas, and Biliary TractFirst Online: 15 July 2016

DOI:            10.1007/s00535-016-1240-y

Cite this article as: Urabe, A., Imamura, M., Tsuge, M. et al. J Gastroenterol (2017) 52: 366. doi:10.1007/s00535-016-1240-y
            

•                         1                           Shares
•                          301                         Downloads
  

   


AbstractBackground

Post-transplant hepatitis B virus (HBV) reinfection is one of the major problems facing patients who undergo HBV-related liver transplantation (LT). We analyzed the clinical impact of serum hepatitis B core-related antigen (HBcrAg) on HBV reinfection in post-LT patients with HBV-related liver diseases.

Methods

Serum hepatitis B surface antigen (HBsAg), HBV DNA, and HBcrAg were measured over time in 32 post-LT patients. Twenty-one out of 32 patients had HCC at LT. The effects of HBcrAg, hepatocellular carcinoma (HCC) recurrence, and HBs gene mutation on HBV reinfection and withdrawal from hepatitis B immune globulin (HBIG) were analyzed.

Results

Sixteen out of 32 patients (50 %) were positive for HBcrAg even though only six patients were thought to have experienced HBV reinfection based on reappearance of either HBV DNA or HBsAg during a median follow-up time of 75 months. Three of these six patients who became re-infected with HBV experienced HCC recurrence after LT. The HBV DNA reappearance rate was significantly higher in patients with HCC recurrence after LT (p < 0.001). Two HBV re-infected patients without HCC recurrence had HBs gene mutations G145R and G145A, respectively. Anti-HBs antibody development rate by HB vaccination was similar between HBcrAg-positive and negative patients (p = 0.325).

Conclusions

HBV reinfection is more common than is usually considered based on conventional measurement of HBsAg and HBV DNA. HCC recurrence and mutations in the HBV S gene were associated with HBV reinfection after LT.

KeywordsLiver transplantationHBV reinfectionHBcrAgHBs gene mutationsHepatitis B immune globulin

StephenW

胃肠病学杂志

2017年3月， 52，Issue 3，pp 366-375
HBV相关肝移植患者HBcrAg与HBV再感染的关系

作者
作者和关系

Ayako UrabeMichio ImamuraMasataka TsugeHiromi KanHatsue FujinoTakayuki Fukuhara Keiichi MasakiTomoki KobayashiAtsushi OnoTakashi NakaharaTomokazu KawaokaAkira HiramatsuYoshiiku KawakamiHiroshi AikataClair Nelson Hayes

绫子urabe
1
今井美
1
Masataka Tsuge
1
Hiromi Kan
1
佐藤富士
1
Fukuhara Takayuki
1
Keiichi Masaki
1
Tomoki Kobayashi
1
Atsushi小野
1
Takashi Nakahara
1
Tomokazu Kawaoka
1
Hiramatsu平井
1
Yoshiiku Kawakami
1
Hiroshi Aikata
1
Clair Nelson Hayes
1
Noboru Maki
2
Hideaki Ohdan
3
Kazuaki Chayama
1电子邮件作者

广岛大学应用生命科学研究所生命医学与健康科学部广岛大学广岛大学
高级生命科学研究所，Wako日本
3.广岛大学生物医学科学大学生物医学研究所外科学科前沿医学科的分类广岛日本

原文 - 肝脏，胰腺和胆道

首先在线：
2016年7月15日

DOI：10.1007 / s00535-016-1240-y

引用本文：
Urabe，A.，Imamura，M.，Tsuge，M。 J Gastroenterol（2017）52：366。doi：10.1007 / s00535-016-1240-y

1股301下载

抽象
背景

移植后乙型肝炎病毒（HBV）再感染是接受HBV相关肝移植（LT）的患者面临的主要问题之一。我们分析了血清乙型肝炎核心相关抗原（HBcrAg）对HBV再感染在HBV相关肝病后LT患者的临床影响。
方法

（HBsAg），HBV DNA和HBcrAg随时间推移在32名LT后患者中测量。 32例患者中有21例在LT患有HCC。分析HBcrAg，肝细胞癌（HCC）复发，HBs基因突变对HBV再感染和从乙型肝炎免疫球蛋白（HBIG）中撤出的影响。
结果

32例患者中有16例（50％）为HBcrAg阳性，即使仅有6例患者在75个月的中位随访时间内基于HBV DNA或HBsAg的再出现被认为经历过HBV再感染。这6例患者中，有3例重新感染HBV，在LT后发生HCC复发。 LT后肝癌复发的HBV DNA复发率显着升高（p <0.001）。 2例HBV复发患者无HBCC复发，HBs基因突变G145R和G145A HB抗体阳性和阴性患者HB抗体发展率相似（p = 0.325）。
结论

HBV重新感染比基于常规测量HBsAg和HBV DNA的赤道更常见。 HCC复发和HBV S基因突变与LT后的HBV再感染相关。
关键词
肝移植HBV再感染HBrAgHBs基因突变乙型肝炎免疫球蛋白

MP4

又是fujirebio