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中国1500万农村夫妇中HBsAg血清阳性率的现状:横断面研究

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才高八斗

发表于 2017-2-22 19:15 |显示全部帖子
Sci Rep. 2017 Feb 21;7:42822. doi: 10.1038/srep42822.
Status of HBsAg seroprevalence in 15 million rural couples in China: a cross-sectional study.Zhang L1,2, Wang YY1,3,4, Huang YJ1,5, Wang QM6, Nelson KE2, Wang AQ7, Shen HP6, Liu XL7, Zhang YP6, Yan DH6, Peng ZQ3, Zhang HG3, Zhang Y3, Zhao J3,4, Wang Y3, Yang Y3, He Y3, Xu JH3, Liu DJ3,4, Guo TJ3,4, Xin XN3,4, Zhou H1,7,8, Ma X1,3,4.
Author information
  • 1Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China.
  • 2Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States.
  • 3National Research Institute for Family Planning, Beijing, China.
  • 4Graduate School of Peking Union Medical College, Beijing, China.
  • 5Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States.
  • 6Department of Maternal and Child Health, National Health and Family Planning Commission of the PRC, Beijing, China.
  • 7Department of Child, Adolescent and Women's Health, School of Public Health, Peking University, Beijing, China.
  • 8Key Laboratory of Reproductive Health, Ministry of Health, Beijing, China.


AbstractA cross-sectional analysis of prevalence of hepatitis B virus infection (HBV) among rural couples was conducted between 2010 and 2014. Serologic HBV markers, including hepatitis B surface antigen (HBsAg) and e antigen (HBeAg), were tested. Primary outcome of interest comprised HBsAg positivity in couples (both positive: F+M+, only wife positive: F+M-, only husband positive: F-M+), and secondary outcome consisted of prevalence and risk factors of HBsAg positivity among husbands or wives. Of 14,816,300 couples included, 0.7% were F+M+; 6.3% were F-M+; 4.4% were F+M-, resulting in the overall seroprevalence of 11.4%. Individually, 6.1% were HBsAg positive with a higher rate seen in husbands (7.0%) than in wives (5.2%). Wife's HBeAg(+)/HBsAg (+) (AOR = 2.61), HBeAg(-)/HBsAg (+) (AOR = 2.23), positivity of syphilis (AOR = 1.50), living in a high-risk region (AOR = 1.46) were significantly predictors of HBsAg positivity in husbands. Prevalence and predictors of HBsAg positivity in wives had similar results. Our data show a high burden and discordant pattern of HBV infection in rural couples, and partner's double positivity of HBeAg and HBsAg was the most significant factor of HBV infection in couples. A comprehensive strategy that emphasizes vaccination and education is needed.


PMID:28220812DOI:10.1038/srep42822

Rank: 8Rank: 8

现金
62111 元 
精华
26 
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30441 
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2009-10-5 
最后登录
2022-12-28 

才高八斗

发表于 2017-2-22 19:16 |显示全部帖子
Sci Rep.2017 Feb 21; 7:42822。 doi:10.1038 / srep42822。
中国1500万农村夫妇中HBsAg血清阳性率的现状:横断面研究。
张丽2,王艳1,3,4,黄艳杰1,王玉梅1,王玉梅2,王玉梅2,王玉1, 4,Wang Y3,Yang Y3,He Y3,Xu JH3,Liu DJ3,4,Guo TJ3,4,Xin XN3,4,Zhou H1,7,8,Ma X1,3,4。
作者信息

    1环境和空间流行病学研究中心,国家人类遗传资源中心,北京,中国。
    2流行病学,Johns Hopkins彭博公共卫生学院,巴尔的摩,马里兰州,美国。
    3国家计划生育研究所,北京,中国。
    中国北京北京协和医学院4 4G学院。
    5卫生政策和管理部,约翰霍普金斯大学彭博公共卫生学院,巴尔的摩,马里兰州,美国。
    6妇幼保健,中华人民共和国国家卫生和计划生育委员会,中国北京。
    7北京大学公共卫生学院儿童,青少年和妇女健康部,中国北京。
    8卫生部生殖健康实验室,北京,中国。

抽象

在2010年至2014年期间,对农村夫妇中乙型肝炎病毒感染(HBV)的流行情况进行了横断面分析。测试了血清学HBV标志物,包括乙型肝炎表面抗原(HBsAg)和e抗原(HBeAg)。主要结局包括夫妇HBsAg阳性(阳性:F + M +,只有妻子阳性:F + M-,只有丈夫阳性:F-M +),次要结果由丈夫HBsAg阳性的患病率和危险因素组成,妻子。在14,816,300对夫妇中,0.7%是F + M +; 6.3%为F-M +; 4.4%为F + M-,导致总体血清阳性率为11.4%。单独地,6.1%的HBsAg阳性,在丈夫(7.0%)中比在妻子(5.2%)中更高的比率。生活在高风险区域(AOR = 2.23)中的妻子的HBeAg(+)/ HBsAg(+)/ HBsAg(+)(AOR = 2.61),HBeAg( - )/ HBsAg(+)(AOR = 1.46)是丈夫HBsAg阳性的显着预测因子。在妻子中HBsAg阳性的流行率和预测因子具有相似的结果。我们的数据显示在农村夫妇的HBV感染的高负担和不一致的模式,合作伙伴的HBeAg和HBsAg的双阳性是夫妇中HBV感染的最重要的因素。需要一个强调疫苗接种和教育的全面战略。

PMID:
    28220812
DOI:
    10.1038 / srep42822
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