HBsAg / HBeAg在1 936 801对夫妇准备在中国农村怀孕的流行率：观

StephenW

J Viral Hepat. 2017 Feb 15. doi: 10.1111/jvh.12693. [Epub ahead of print]
Prevalence of HBsAg/HBeAg among 1 936 801 couples preparing for pregnancy in rural China: An observational study.Liu J1, Zhang S2, Wang Q2, Ping S2, Zhang M3, Zhang Y2, Yan D2, Liu M4.
Author information

• 1Department of Child, Adolescent and Women's Health, School of Public Health, Peking University, No.38, Xueyuan Road, Haidian District, Beijing, 100191, China.
• 2Department of Maternal and Child Health, National Health and Family Planning Commission of the PRC, No.14, Zhichun Road, Haidian District, Beijing, 100190, China.
• 3Center for Clinical Laboratory, Beijing Shijitan Hospital, Capital Medical University, Tieyilu 10, Yangfangdian, Haidian District, Beijing, 100038, China.
• 4Department of Epidemiology and Biostatistics, School of Public Health, Peking University, No.38, Xueyuan Road, Haidian District, Beijing, 100191, China.
  

AbstractOBJECTIVE: There are few extant studies on the prevalence of HBV infection in couples preparing for pregnancy. We assessed the prevalence of hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) in couples preparing for pregnancy in rural China, and the association between HBV prevalence and the statuses of HBsAg/HBeAg and ALT in the spouses.
METHODS: We performed a nationwide cross-sectional study, using data from a health check-up program for 1 936 801 rural couples from 31 provinces preparing for pregnancy between 2010 and 2012. ELISA was used to test serologic samples, and we defined couples who were either discordant or both positive for HBsAg as "POSITIVE COUPLES" (PC).
RESULTS: Among the 1 936 801 couples, 202 816 (10.47%; 95% CI, 10.43%-10.51%) were PC. HBeAg (high infectiousness) was detected in 56 474 (27.84%; 95% CI, 27.65%-28.04%) of 202 816 HBsAg-positive couples. Multivariate models showed that the prevalence of HBV infection in wives increased along with the positive statuses for HBsAg/HBeAg and alanine aminotransferase (ALT) of their husbands (adjusted odds ratio increased from 2.31 to 4.98), after adjustment for potential confounders. Similarly, the prevalence of HBV infection in husbands was associated with the positive statuses of HBsAg/HBeAg and ALT of their wives (adjusted odds ratio increased from 2.04 to 4.93).
CONCLUSIONS: The prevalence of POSITIVE COUPLES in couples preparing for pregnancy in rural China was high, and the prevalence of HBV infection was independently associated with the positive statuses of HBsAg/HBeAg and ALT of the spouses. Instead of solely focusing on mothers prior to becoming pregnant, POSITIVE COUPLES should be taken as an important unit of care. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.

KEYWORDS: disease prevalence; epidemiology; hepatitis B virus; preconception health

PMID:28199770DOI:10.1111/jvh.12693

StephenW

J病毒Hepat。 2017年2月15日。doi：10.1111 / jvh.12693。 [打印前的电子版]
HBsAg / HBeAg在1 936 801对夫妇准备在中国农村怀孕的流行率：观察性研究。
Liu J1，Zhang S2，Wang Q2，Ping S2，Zhang M3，Zhang Y2，Yan D2，Liu M4。
作者信息

1北京大学公共卫生学院儿童青少年与妇女健康部，北京市海淀区学院路38号，100191。
2.中华人民共和国国家卫生和计划生育委员会，中国北京市海淀区志春路14号，100190。
3首都医科大学北京市石家庄医院临床实验室北京市海淀区阳坊店铁里楼10号邮编100038。
4北京大学公共卫生学院流行病学与生物统计学系，北京市海淀区学院路38号，100191。

抽象
目的：

在准备怀孕的夫妇中，很少有关于HBV感染流行的研究。在中国农村，夫妇准备妊娠的夫妇中的乙型肝炎表面抗原（HBsAg）和乙型肝炎抗原（HBeAg）的流行率，以及HBV流行率与HBsAg / HBeAg和ALT在配偶中的状态之间的关系。
尿：

我们使用来自31个省的1 936 801名农村夫妇的健康检查计划的数据进行了一项全国性的横断面研究，为2010年至2012年的怀孕做准备.ELISA用于测试血清学样本，我们定义夫妇不一致或两者都是阳性的HBsAg作为“正向耦合”（PC）。
结果：

（HBeAg阳性伴侣HBeAg（高剂量）在56 474例（27.84％; 95％CI，27.65％-28.04％）中检测到HBsAg（高感染性）;多变量模型显示HBV感染的发生率妻子与丈夫的HBsAg / HBeAg和丙氨酸氨基转移酶（ALT）的阳性状态一起使用（调整后的比值比从2.31增加到4.98），同样，在丈夫中的HBV感染的流行与HBsAg / HBeAg和ALT的阳性状态（调整的优势比从2.04增加到4.93）。
结论：

在中国农村，夫妇准备怀孕的阳性夫妇的职业是高的，HBV感染的流行与配偶的HBsAg / HBeAg和ALT的阳性状态独立相关。阳性对象应该作为一个重要的护理单位。本文受版权保护。

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关键词：

前列腺病;流行病学

PMID：
28199770
DOI：
10.1111 / jvh.12693