看了一篇文献，似乎已经证明了替诺对母乳的孩子没有影响

familyjiankang

对50组吃替诺的并哺乳的母亲和孩子进行研究，母亲的母乳中替诺的浓度只有血液浓度的3%，另外是94%的婴儿的血液中的替诺都是不可测量的！
另外求大神指点：“ Based on the milk concentration, the infants had TFV exposures at less than 0.01% of the proposed infant therapeutic dose (6 mg/kg)”这句话应该怎么翻译啊？
求大神找一下这篇文章的文献原文呢！
感谢啊，一位纠结的替诺待产妈妈们！
以下是我搜的文章原文：
TDF/FTC can be used as PrEP by breastfeeding mothers without risk to the baby

Simon Collins, HIV i-Base

A study reporting that low TDF/FTC concentrations in breastmilk do not put a baby at risk will be important in enabling women to routinely use PrEP irrespective of whether or not they are breastfeeding.

Kenneth Mugwanya from University of Washington presented results from a pharmacokinetic study in 50 mother and infant pairs. The mothers were given daily PrEP for ten days with drugs levels measured in both breast milk samples and infant plasma samples. [1]

Median age of the infants was 13 weeks.

Only very small quantities of tenofovir (median med 0.2 ng/mL) transferred to milk – approximately at 3% of blood levels in the mothers. Tenofovir was not quantifiable in 94% of infant plasma samples. Based on the milk concentration, the infants had TFV exposures at less than 0.01% of the proposed infant therapeutic dose (6 mg/kg).

Emtricitabine (FTC) concentrations in breast milk were also low, although somewhat higher (median 212.5 ng/mL). These concentrations were consistent with those seen with 3TC, abacavir and AZT. Overall, 47/49 samples had detectable FTC in infant plasma, but at small concentrations (13.2 ng/mL), equivalent to approximately 0.5% of the proposed therapeutic infant dose.

Even though this was a small study, it provides the first data to suggest that PrEP can be safely used by women who are breastfeeding.

Full results from the study were published as an open access paper in PLoS Medicine in September 2016. [2]

雁过留声

要不要替诺母乳，其实就是看你自己本人的想法

bobokuku

我也在纠结中，听说广州南方医院的侯金林大夫发表了一篇关于服用替诺期间母乳喂养的文章，在医学论坛杂志上，结论是浓度很低可以喂养，有人找到过这篇文章吗？我在知网没找到啊

familyjiankang

回复 雁过留声 的帖子

本人是非常想给宝宝哺乳的。
但是就是担心替诺妈妈哺乳，对宝宝会有什么不利。
雁姐能给解疑一下吗？

雁过留声

那你担心有什么不利？

familyjiankang

回复 雁过留声 的帖子

担心孩子通过母乳吃到替诺，对他的身体健康不好。

雁过留声

按你这样说法，那怀孕就不能吃替诺了。

酸糖果29

个人觉得如果实在担心就索性不要母乳的话，不然以后就算母乳了，娃有个什么不舒服就会归结到这个母乳上的，现在纯奶粉的娃也很多的，就是抵抗力会稍微差点。

familyjiankang

回复 雁过留声 的帖子

雁姐，是否可以这样说，完全不用担心替诺妈妈哺乳时，替诺对孩子的影响？因为通过母乳传递给孩子的替诺量实在是太小了，几乎微乎其微！

雁过留声

回复 familyjiankang 的帖子

可以这样说