丙氨酸氨基转移酶比慢性乙型肝炎患者的其他肝脏标志物对

StephenW

J Clin Lab Anal. 2017 Jan 23. doi: 10.1002/jcla.22141. [Epub ahead of print]
Alanine aminotransferase is more sensitive to the decrease in hepatitis B virus-DNA load than other liver markers in chronic hepatitis B patients.Wang HB1, Wang QY2, Yuan Q1, Shan XY1, Fu GH1.
Author information

• 1Department of Clinical Laboratory, Jinhua Central Hospital, Jinhua, China.
• 2Wenzhou Medical College, Wenzhou, China.
  

AbstractBACKGROUND: A direct correlation between hepatitis B virus DNA (HBV-DNA) and liver markers has not been identified in chronic hepatitis B (CHB) patients. However, the effect of HBV-DNA changes on liver markers remains unclear. We explored the association between decreased HBV-DNA and liver makers in CHB patients.
METHODS: Chronic hepatitis B patients who visited Jinhua Central Hospital twice were selected for analysis. Finally, 171 participants with a 1-log reduction in HBV-DNA between the two visits were enrolled as the case group, and 158 participants with no significant changes in HBV-DNA were enrolled as the control group.
RESULTS: There was no significant correlation between HBV-DNA and liver markers (P>.05). However, in longitudinal analysis, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGT) were significantly different between the two tests (P<.05) in the case group. Conversely, there was no significant difference in the control group. When HBV-DNA decreased >26 times, ALT was reduced by half or more. A similar trend was observed with a decrease of >63 times for AST and a decrease of >76 times for GGT.
CONCLUSIONS: A large change in HBV-DNA can lead to a significant variation in liver markers. In particular, ALT was more sensitive than other liver markers to a reduction in HBV-DNA.

© 2017 Wiley Periodicals, Inc.

KEYWORDS: CHB patients; HBV-DNA load; liver markers

PMID:28116822DOI:10.1002/jcla.22141

StephenW

J Clin Lab Anal。 2017年1月23日。doi：10.1002 / jcla.22141。 [打印前的电子版]
丙氨酸氨基转移酶比慢性乙型肝炎患者的其他肝脏标志物对乙型肝炎病毒-DNA负荷的减少更敏感。
Wang HB1，Wang QY2，Yuan Q1，Shan XY1，Fu GH1。
作者信息

中国金华金华中心医院临床实验室。
2温州医学院，温州。

抽象
背景：

在慢性乙型肝炎（CHB）患者中尚未鉴定出乙型肝炎病毒DNA（HBV-DNA）和肝脏标志物之间的直接相关性。然而，HBV-DNA变化对肝脏标志物的影响仍不清楚。我们探讨了CHB患者HBV-DNA下降与肝脏生产者之间的关系。
方法：

两次随访之间的HBV-DNA作为病例组，并且两次随访之间HBV-DNA没有显着变化的158名参与者作为病例组入组，并且158名HBV-DNA没有显着变化的参与者被登记为对照组。
结果：

（ALT），天冬氨酸氨基转移酶（AST）和γ-谷氨酰转肽酶（GGT）在HBV-DNA和肝脏标记物之间差异显着（P> 0.05）。然而，纵向分析，丙氨酸氨基转移酶两组试验（P <0.05）。相反，在对照组中没有显着差异。当HBV-DNA减少> 26倍时，ALT减少一半或更多。 AST> 63次，GGT降低> 76次。
结论：

HBV-DNA的大变化可导致肝标记物的显着变化。特别是，ALT比其他肝脏标志物更敏感，减少HBV-DNA。

©2017 Wiley Periodicals，Inc.
关键词：

CHB患者; HBV-DNA负荷;肝标记

PMID：
28116822
DOI：
10.1002 / jcla.22141tor