[江苏省HBeAg血清学转换的慢性乙型肝炎患者HBeAg逆转的流行病

StephenW

Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Jan 10;38(1):43-48. doi: 10.3760/cma.j.issn.0254-6450.2017.01.008.
[Epidemiological characteristics of HBeAg reversion in chronic hepatitis B patients with HBeAg seroconversion in Jiangsu province, 2012-2014]. [Article in Chinese;  Abstract available in Chinese from the publisher]
Zhu LG1, Tian H2, Jiang J1, Song C3, Zou Y4, Xu JF5, Liu HJ6, Peng H1, Hu ZB7, Zhu FC1, Shen HB3, Zhai XJ1.
Author information

• 1Major Project Executive Office, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
• 2Acute Infectious Disease Prevention Section, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
• 3School of Public Health, Nanjing Medical University 210029, China.
• 4Epidemic Prevention Section, Zhangjiagang County Center for Disease Control and Prevention, Zhangjiagang 215600, China.
• 5Epidemic Prevention Section, Danyang County Center for Disease Control and Prevention, Danyang 212310, China.
• 6Major Project Executive Office, Taixing County Center for Disease Control and Prevention, Taixing 225400, China.
• 7Animal Care Facility, Nanjing Medical University 210029, China.
  

Abstractin                                English, Chinese
Objective: To understand characteristics and influencing factors of reversion of HBeAg in chronic hepatitis B patients with HBeAg sero-conversion, and provide epidemiological evidence for the regular management of chronic hepatitis B patients. Methods: From 2012 to 2014, a cohort study was conducted among the chronic hepatitis B patients with sero-conversion of HBeAg in Jiangsu province. Association between participants' demographics, ALT, HBV DNA and incidence of HBeAg reversion was analyzed by Cox regression model. HBV DNA changing trend between patients with HBeAg reversion and patients with persistent HBeAg sero-conversion was compared by repeated measure data variance analysis. Results: In 2012, there were 5 068 HBeAg seroconverted chronic hepatitis B patients aged (51.9 ± 12.8) years enrolled. By 2014, HBeAg had reversed in 121 cases with the rate of 1.3/100 person-years. The probability of HBeAg reversion decreased with the age of the patients. By Cox regression analysis, HBV DNA level was an important influencing factor for the progress of HBeAg reversion. The patients with HBV DNA≥200 000 IU/ml had a higher HBeAg reversion rate DNA (3.8/100 person-years) than those with HBV DNA <2 000 IU/ml (1.1 person-years) (HR=3.44, 95% CI: 1.91-6.20, P=0.000). Compared with the persistent HBeAg sero-conversion group, HBV DNA and ALT showed a more dramatic increase in the HBeAg reversion group (P=0.000). Conclusions: There was a certain HBeAg reversion rate in chronic hepatitis B patients with HBeAg sero-conversion. Younger chronic CHB patients with HBeAg sero-conversion and those with higher HBV DNA lever had higher HBeAg reversion rate. Following up and management of chronic CHB patients with HBeAg sero-conversion is important and helpful for the control of hepatitis B.


KEYWORDS: Cohort; HBeAg; Hepatitis B; Reversion

PMID:28100375

StephenW

中华刘兴兵薛子志。 2017 Jan 10; 38（1）：43-48。 doi：10.3760 / cma.j.issn.0254-6450.2017.01.008。
[江苏省HBeAg血清学转换的慢性乙型肝炎患者HBeAg逆转的流行病学特征，2012-2014]。
[中文;摘要中文摘要：
Zhu LG1，Tian H2，Jiang J1，Song C3，Zou Y4，Xu JF5，Liu HJ6，Peng H1，Hu ZB7，Zhu FC1，Shen HB3，Zhai XJ1。
作者信息

    江苏省疾病预防控制中心重大项目执行办公室，南京210009。
    江苏省疾病预防控制中心，江苏省南京市210009 2级传染病预防科。
    南京医科大学公共卫生学院210029。
    张家港市疾病预防控制中心预防学科，张家港市215600。
    5丹阳县疾病预防控制中心预防科，丹阳212310。
    6泰兴县疾病预防控制中心重点项目办公室，泰兴225400。
    7南京医科大学学报（医学版）。

摘要英语，中文

目的：了解HBeAg逆转HBeAg血清转换的慢性乙型肝炎患者的特点和影响因素，为慢性乙型肝炎患者的常规管理提供流行病学证据。方法：2012 - 2014年，江苏省HBeAg血清转换慢性乙型肝炎患者进行队列研究。通过Cox回归模型分析参与者的人口统计学，ALT，HBV DNA和HBeAg逆转的发生率之间的关联。通过重复测量数据方差分析，比较HBeAg逆转患者和持续HBeAg血清转换患者的HBV DNA变化趋势。结果：2012年，有5 068例HBeAg血清转化的慢性乙型肝炎患者年龄（51.9±12.8）岁。到2014年，HBeAg逆转121例，比率为1.3 / 100人年。 HBeAg逆转的概率随着患者的年龄而下降。通过Cox回归分析，HBV DNA水平是HBeAg逆转进展的重要影响因素。 HBVDNA≥200000 IU / ml的患者比HBV DNA <2 000 IU / ml（1.1人年）（HR = 3.44,95％）的HBeAg逆转率DNA（3.8 / 100人年） CI：1.91-6.20，P = 0.000）。与持续性HBeAg血清转换组相比，HBV DNA和ALT在HBeAg逆转组中显着增加（P = 0.000）。结论：在HBeAg血清转化的慢性乙型肝炎患者中有一定的HBeAg逆转率。年轻慢性CHB患者HBeAg血清转换和那些与高HBV DNA杠杆有较高的HBeAg回复率。随访和管理慢性CHB患者HBeAg血清转化是重要的，有助于控制乙型肝炎。
关键词：

队列; HBeAg;乙型肝炎;反转

PMID：
    28100375