HBsAg血清清除在乙型肝炎病毒载体在韩国的临床特点：回顾性

StephenW

World J Gastroenterol. 2016 Nov 28;22(44):9836-9843.
Clinical features of HBsAg seroclearance in hepatitis B virus carriers in South Korea: A retrospective longitudinal study.Park YM1, Lee SG1.
Author information

• 1Young Min Park, Hepatology Center, Department of Internal Medicine and Biomedical Research Center, Bundang Jesaeng General Hospital, Seongnam-si, Gyeonggi-do 13589, South Korea.
  

AbstractAIM: To investigate the characteristic features of hepatitis B surface antigen (HBsAg) seroclearance among Korean hepatitis B virus (HBV) carriers.
METHODS: Carriers with HBsAg seroclearance were selected by analyzing longitudinal data collected from 2003 to 2015. The period of time from enrollment to the negative conversion of HBsAg (HBsAg-NC) was compared by stratifying various factors, including age, sex, hepatitis B e antigen (HBeAg), HBV DNA, sequential changes in the signal-to-cutoff ratio of HBsAg (HBsAg-SCR), as measured by qualitative HBsAg assay, and chronic liver disease on ultrasonography (US-CLD). Quantification of HBV DNA and HBsAg (HBsAg-QNT) in the serum was performed by commercial assay.
RESULTS: Among the 1919 carriers, 90 (4.7%) exhibited HBsAg-NC at 6.2 ± 3.6 years after registration, with no differences observed among the different age groups. Among these carriers, the percentages of those with asymptomatic liver cirrhosis (LC) and hepatocellular carcinoma (HCC) at registration were 31% and 7.8%, respectively. The frequency of HBsAg-NC significantly differed according to the HBV DNA titer and US-CLD. HBeAg influenced HBsAg-NC in the 40-50 and 50-60 year age groups. HBsAg-SCR < 1000 was correlated with an HBsAg-QNT < 200 IU/mL. A gradual decrease in the HBsAg-SCR to < 1000 predicted HBsAg-NC. Six patients developed HCC after registration, including two before and four after HBsAg-NC. The rate at which the patients developed new HCC after HBsAg seroclearance was 4.8%. LC with excessive drinking and vertical infection were found to be risk factors for HCC in the HBsAg-NC group.
CONCLUSION: HCC surveillance should be continued after HBsAg seroclearance. An HBsAg-SCR < 1000 and its decrease in sequential testing are worth noting as predictive markers of HBsAg loss.


KEYWORDS: HBeAg; HBsAg; Hepatitis B Surface antigen; Hepatitis B e antigen; Hepatitis B virus; Hepatocellular carcinoma; Liver cirrhosis; Seroconversion

PMID:27956808DOI:10.3748/wjg.v22.i44.9836
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StephenW

世界胃肠病学杂志。 2016 Nov 28; 22（44）：9836-9843。
HBsAg血清清除在乙型肝炎病毒载体在韩国的临床特点：回顾性纵向研究。
Park YM1，Lee SG1。
作者信息

    1Young Min Park，Hepatology Center，Department of Internal Medicine and Biomedical Research Center，Bundang Jesaeng General Hospital，Seongnam-si，Gyeonggi-do 13589，South Korea。

抽象
目标：

探讨乙型肝炎病毒（HBV）携带者乙型肝炎表面抗原（HBsAg）seroclearance的特征。
方法：

通过分析从2003年至2015年收集的纵向数据来选择具有HBsAg血清清除的携带者。通过将包括年龄，性别，乙型肝炎抗原（HBsAg-NC）的各种因素进行分类来比较从入选到HBsAg HBeAg），HBV DNA，通过定性HBsAg测定法测定的HBsAg（HBsAg-SCR）的信号 - 截止比和超声检查中的慢性肝病（US-CLD）的连续变化。通过商业测定进行血清中HBV DNA和HBsAg（HBsAg-QNT）的定量。
结果：

在1919个运营商中，90（4.7％）在登记后6.2±3.6年显示HBsAg-NC，在不同年龄组之间没有观察到差异。在这些携带者中，无症状肝硬化（LC）和肝细胞癌（HCC）在登记时的百分比分别为31％和7.8％。 HBsAg-NC的频率根据HBV DNA滴度和US-CLD显着不同。 HBeAg在40-50和50-60岁年龄组影响HBsAg-NC。 HBsAg-SCR <1000与HBsAg-QNT <200IU / mL相关。 HBsAg-SCR逐渐减少至<1000预测的HBsAg-NC。 6例患者在注册后发展为HCC，包括HBsAg-NC前2例和后4例。 HBsAg血清清除后患者发展新的HCC的发生率为4.8％。在HBsAg-NC组中，发现有过度饮酒和垂直感染的LC是HCC的危险因素。
结论：

HBsAg血清清除后应继续进行肝癌监测。 HBsAg-SCR <1000及其在顺序测试中的减少值得注意作为HBsAg缺失的预测标记物。
关键词：

HBeAg; HBsAg;乙型肝炎表面抗原;乙型肝炎抗原;乙型肝炎病毒;肝细胞癌;肝硬化;血清转换

PMID：
    27956808
DOI：
    10.3748 / wjg.v22.i44.9836

疯一点好

唉，即使表面抗原转阴了又有什么用，癌症发病率还是和没有转阴的一样，看了心烦啊。