打破乙肝病毒宽容和基于模仿T细胞依赖性抗原诱导保护性免

StephenW

Viral Immunol. 2016 Sep 23. [Epub ahead of print]
Breaking Hepatitis B Virus Tolerance and Inducing Protective Immunity Based on Mimicking T Cell-Independent Antigen.Li X1,2, Ni R1.
Author information

• 11 Department of Gastroenterology, Affiliated Hospital of Nantong University , Nantong, China .
• 22 The Clinical Research Center, Affiliated Hospital of Nantong University , Nantong, China .
  

AbstractThere are over 350 million chronic carriers of hepatitis B virus (HBV) in the world, of whom about a third eventually develop severe HBV-related complications. HBV contributes to liver cirrhosis and hepatocellular carcinoma development. Remarkable progress has been made in selective inhibition of HBV replication by nucleoside analogs. However, how to generate protective antibody of HBsAb in HBV-infected patients after HBV-DNA becomes negative still remains a challenge for scientists. In this study, we show that OmpC-HBsAg 'a' epitope chimeric protein vaccine can break HBV tolerance and induce protective immunity in HBV transgenic mice based on mimicking T cell-independent antigen to bypass T cells from the adaptive immune system. The antibodies induced by the vaccine have the ability to prevent HBV virion infection of human hepatocytes.


PMID:27662269DOI:10.1089/vim.2016.0052

StephenW

病毒免疫。 2016年九月23 [提前打印EPUB]
打破乙肝病毒宽容和基于模仿T细胞依赖性抗原诱导保护性免疫。
李X1,2，倪R1。
作者信息

    消化11部，南通大学，南通，中国的附属医院。
    22临床研究中心，南通大学附属医院，南通，中国。

抽象

有超过3.5亿的全球乙型肝炎病毒（HBV）的慢性携带者，其中大约三分之一最终会发展为严重的HBV相关并发症。 HBV有助于肝硬化和肝细胞癌的发展。显着的进步已经由核苷类似物HBV复制的选择性抑制作出的。然而，如何产生在HBV感染的病人乙肝表面的保护性抗体后HBV-DNA变为负仍然为科学家是一个挑战。在这项研究中，我们表明，OMPC-HBsAg的'一'表位的嵌合蛋白质的疫苗可以打破乙肝耐受并诱导基于模仿的T细胞非依赖性抗原从适应性免疫系统绕过T细胞中HBV转基因小鼠的保护性免疫。由疫苗诱导的抗体具有防止人肝细胞的HBV病毒粒子感染的能力。

结论：
    27662269
DOI：
    10.1089 / vim.2016.0052