单届肝动脉化疗栓塞与微波消融或肝癌射频消融治疗疗效比

StephenW

    European Journal of Gastroenterology & Hepatology:   
    October 2016 - Volume 28 - Issue 10 - p 1198–1203
            doi: 10.1097/MEG.0000000000000688
    Original Articles: Hepato-cellular Carcinoma
  
  Comparison of single-session transarterial chemoembolization combined with microwave ablation or radiofrequency ablation in the treatment of hepatocellular carcinoma:  a randomized-controlled study      

Sheta, Elshazly; El-Kalla, Ferial; El-Gharib, Mohamed; Kobtan, Abdelrahman; Elhendawy, Mohammed; Abd-Elsalam, Sherief; Mansour, Loai; Amer, Ibrahim

              
   
   
  
      [url=][/url]Abstract      
   
         

Background: Globally, hepatocellular carcinoma (HCC) is the third most frequent cause of cancer-related mortality. In recent years, transarterial chemoembolization, radiofrequency ablation, and microwave ablation (MWA) have been accepted as treatment modalities for patients with surgically unresectable HCC.

      

Aim of this work: This study aimed to compare combination treatment with radiofrequency or MWA, followed by transarterial chemoembolization, and performed in a single session.

      

Patients and methods: This study was carried out on 50 patients with nonresectable single-lesion HCC, who were divided into three groups: group A included 20 patients treated by transcatheter hepatic arterial chemoembolization, group B included 20 patients treated by radiofrequency thermal ablation combined with transcatheter arterial chemoembolization, and group C included 10 patients treated by MWA combined with transcatheter arterial chemoembolization. The combined treatments were performed in a single session, with the ablation performed first.

      

Results: The total success rate in this study at 6 months following the procedure was 50% in group A, 70% in group B, and 80% in group C. Major complications were recorded in 22% of patients. The number of complications was the highest in group A.

      

Conclusion: Combined ablation with chemoembolization is superior in the treatment of nonresectable single masses larger than 4 cm. Transcatheter arterial chemoembolization and ablation can be performed safely and successfully during a single session, which has not been found to decrease the response rates to treatment. Combined treatment with MWA is more effective in terms of tumor response, and results in the same complication rate as with radiofrequency, but less than chemoembolization alone.

   
  

StephenW

欧洲胃肠病学杂志与肝病学：
2016年10月 - 28卷 - 10期 - P 1198至1203年
DOI：10.1097 / MEG.0000000000000688
原创文章：肝细胞癌
单届肝动脉化疗栓塞与微波消融或肝癌射频消融治疗疗效比较：一项随机对照研究

Sheta，Elshazly;埃尔 - 卡拉，平日;埃尔 - 加里卜，穆罕默德; Kobtan，Abdelrahman; Elhendawy，穆罕默德;阿卜杜勒Elsalam，Sherief;曼苏尔，Loai;阿米尔，易卜拉欣
抽象

背景：在全球范围内，肝细胞癌（HCC）是癌症相关死亡的第三个最常见的原因。近年来，化学栓塞，射频消融，微波消融（MWA）已被接受为患者手术无法切除的肝癌的治疗方式。

这项工作的目的：本研究旨在用射频或微波消融比较联合治疗，随后化学栓塞，并在单个会话中执行。

病人和方法：本研究对50例不可切除的单病灶HCC，谁被分成三组进行：A组包括20例患者通过肝动脉化疗栓塞治疗，B组包括射频消融联合治疗20例肝动脉化疗栓塞，C组包括MWA与肝动脉化疗栓塞结合治疗10例。合并后的治疗是在一个会话中执行，以烧蚀进行第一。

结果：以下的步骤在本研究的总的成功率在6个月是在A组的50％，在B组的70％，而在C组主要并发症，记录在22％的患者的80％。并发症的数目是在基团A中的最高

结论：综合消融介入治疗是不可切除单群众大于4cm的治疗优越。肝动脉化疗栓塞和消融在单个会话，它一直没有找到降低响应率在治疗过程中安全地和成功地执行。与MWA联合治疗是在肿瘤反应方面更有效，并且导致相同的并发症发生率，与射频，但小于单独化疗栓塞。

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