孕妇患有慢性乙肝病毒感染者血清中25-羟基维生素D的地位

StephenW

J Infect Dev Ctries. 2016 Aug 31;10(8):851-856. doi: 10.3855/jidc.6600.
Serum 25-hydroxyvitamin D status in pregnant women with chronic hepatitis B virus infection.Gao XR1, Wang CM, Wang WJ, Han GR, Zhang JQ.
Author information

• 1Medical School Southeast University, Nanjing, Jiangsu, China. [email protected].
  

AbstractINTRODUCTION: Maternal 25-hydroxyvitamin D [25(OH)D] deficiency has a negative influence on the health of the mother and the developing fetus. The aim of this study was to assess serum 25(OH)D status and its relationship to virologic and biochemical parameters in pregnant women with chronic hepatitis B virus (HBV) infection.
METHODOLOGY: Serum 25(OH)D levels among 142 pregnant women with chronic HBV infection and 251 healthy pregnant women were measured using enzyme-linked immunosorbent assay.
RESULTS: The mean±SD values for serum 25(OH)D levels were 13.63±5.5 ng/mL in healthy pregnant women and 12.05±3.3 ng/mL in pregnant women with chronic HBV infection (p < 0.01). Serum 25(OH)D levels were associated with seasonal variation in healthy pregnant women (p = 0.01); however, similar results were not observed in pregnant women with chronic HBV infection (p = 0.10). Furthermore, multivariate analysis indicated that only ALT level was independently associated with severe vitamin D deficiency (p = 0.01). A significant positive correlation was found between serum 25(OH)D level and ALT level in pregnant women with chronic HBV infection (r = 0.32; p < 0.001).
CONCLUSIONS: Vitamin D levels were lower in pregnant women with chronic HBV infection compared with healthy pregnant women. Vitamin D supplementation can be routinely recommended for pregnant women in China.


PMID:27580331

StephenW

Ĵ传染开发Ctries。 2016年8月31日; 10（8）：851-856。 DOI：10.3855 / jidc.6600。
孕妇患有慢性乙肝病毒感染者血清中25-羟基维生素D的地位。
高XR1，王CM，王文健，韩GR，张JQ。
作者信息

    1医药东南大学，南京，江苏，中国。 [email protected]。

抽象
介绍：

母体25-羟基维生素D [25（OH）D]缺乏对母亲的健康和发育中的胎儿产生负面影响。这项研究的目的是评估血清25（OH）D的地位及其与病毒学和生化指标与慢性乙型肝炎病毒（HBV）感染的关系孕妇。
方法：

采用酶联免疫吸附法测定142孕妇慢性HBV感染者和251健康孕妇血清中25（OH）D的水平。
结果：

平均±血清25（OH）D水平SD值分别为13.63±5.5毫微克/毫升的健康孕妇和12.05±3.3毫微克/毫升的孕妇患有慢性HBV感染者（P <0.01）。血清25（OH）D水平与健康孕妇（P = 0.01）季节变化有关;然而，类似的结果未在孕妇慢性HBV感染（p值= 0.10）观察到。此外，多变量分析表明，只有ALT水平是独立的严重缺乏维生素D（p值= 0.01）相关联。一个显著的正相关关系，发现血清25之间（OH）孕妇慢性HBV感染维生素D水平与ALT水平相关（r = 0.32，P <0.001）。
结论：

维生素D水平与健康孕妇相比，慢性HBV感染者是孕妇低。补充维生素D可以常规建议孕妇在中国。

结论：
    27580331