瞬时弹性成像与血清乙肝表面抗原增强肝纤维化检测。

StephenW

Med Sci Monit. 2016 Aug 15;22:2878-2885.
Transient Elastography with Serum Hepatitis B Surface Antigen Enhances Liver Fibrosis Detection.Dai T1, Si J2, Hao M3, Li C4, Liu X5, Li J5, Ma A6.
Author information

• 1Department of Cardiology, Capital Medical University Affiliated Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China (mainland).
• 2Department of Infectious Diseases, JiaYuguan's First Hospital, Jiayuguan, Gansu, China (mainland).
• 3Department of Ultrasound, Japan-China Friendship Hospital, Beijing, China (mainland).
• 4Department of Ultrasound, Japan-China Friendship Hospital, Beijing , China (mainland).
• 5Department of Pathology, Japan-China Friendship Hospital, Beijing, China (mainland).
• 6Department of Infectious Diseases, Japan-China Friendship Hospital, Beijing, China (mainland).
  

AbstractBACKGROUND The aim of this study was to explore transient elastography (TE) with quantitative hepatitis B surface antigen (qHBsAg) for detecting advanced hepatic fibrosis. MATERIAL AND METHODS This was a single-center prospective real-life analysis of 111 treatment-naïve chronic hepatitis B (CHB) patients enrolled into the Establishment of Non-invasive Diagnosis Criteria and Model of Hepatitis B Virus-related Cirrhosis Study. RESULTS There were significant correlations between TE, qHBsAg, and fibrosis. Both qHBsAg and TE were identified as independent predictors for advanced fibrosis. In receiver operating characteristic curve (ROC) analysis, TEqHBsAg (combination of TE and qHBsAg) resulted in the highest area under the receiver-operator curve (AUC) (0.912), mainly due to increased specificity. Using the optimal cut-off, TEqHBsAg provided a sensitivity of 86.7%, and increased specificity from 78.7% to 85.1%. CONCLUSIONS Combining TE with qHBsAg enhances specificity in identifying advanced fibrosis in treatment-naïve CHB patients.


PMID:27526179

StephenW

医学科学monit的。 2016年8月15日22：2878年至2885年。
瞬时弹性成像与血清乙肝表面抗原增强肝纤维化检测。
戴T1，思J2，郝M3，李C4，刘X5，李J5，马A6。
作者信息

    心内科教研室，首都医科大学附属北京安贞医院，心脏，肺北京理工大学和血管疾病，北京，中国（大陆）。
    传染病教研室，嘉峪关的第一医院，嘉峪关，甘肃省，中国（大陆）。
    超声3Department，日本中国友好医院，北京，中国（大陆）。
    超声4Department，日本中国友好医院，北京，中国（大陆）。
    病理5Department，日本中国友好医院，北京，中国（大陆）。
    传染病6Department，日本中国友好医院，北京，中国（大陆）。

抽象

背景技术本研究的目的是探讨瞬时弹性（TE）与定量乙肝表面抗原（qHBsAg），用于检测先进肝纤维化。材料和方法这是111治疗初治慢性乙型肝炎的单中心前瞻性现实生活中的分析（CHB）患者参加到非侵入性诊断标准的建立及示范乙型肝炎病毒相关的肝硬化研究。结果两组TE，qHBsAg和纤维化的显著相关性。无论qHBsAg和TE被确定为晚期肝纤维化的独立预测因子。在接收器操作特征曲线（ROC）分析，TEqHBsAg（TE和qHBsAg的组合）导致接收机的操作员曲线（AUC）（0.912），主要是由于提高的特异性下的最高区域。使用最佳截止，TEqHBsAg提供86.7％的灵敏度和增加的特异性从78.7％至85.1％。结论与qHBsAg结合TE增强了识别初治慢性乙肝患者肝纤维化的特异性。

结论：
    27526179