循环炎性标记物为肝癌的系统评价

StephenW

Systematic evaluation of circulating inflammatory markers for hepatocellular carcinoma
Authors

    Accepted manuscript online: 8 August 2016Full publication history
    DOI: 10.1111/liv.13218View/save citation
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Abstract
Backgrounds & Aims

A number of circulating inflammatory factors are implicated in the pathogenesis and prognostication of hepatocellular carcinoma (HCC). We aim to evaluate the prognostication of multiple serum inflammatory factors simultaneously and develop an objective inflammatory score for HCC.
Methods

A prospective cohort of 555 patients with HCC with paired serum samples was accrued from 2009 to 2012. The blood levels of conventional inflammatory markers, namely C-reactive protein (CRP), albumin, neutrophils, lymphocytes and platelet, were determined, and 41 other exploratory markers were measured by a multiplex assay. The prognostication and interaction of markers were determined by univariate and multivarite analyses.
Results

The cohort was randomly divided into training cohort (n=139) and validation cohort (n=416). There were no differences in baseline characteristics between the two cohorts. In the training cohort, independent prognostic factors for overall survival included CRP [hazard ratio (HR) 1.107; p=0.003], albumin (HR 0.953; p=0.032) and interleukin-8 (HR=5.816; p<0.001). We have modified the existing inflammation based index (IBI) by adding serum interleukin-8 level. The modified IBI could stratify patients into four groups with distinct overall survival (p<0.001). The results were also validated in the validation cohort. When compared with IBI and other conventional inflammatory markers, the modified IBI had better prognostic performance with higher c-index and homogeneity likelihood ratio chi-square.
Conclusions

Amongst the conventional and exploratory circulating inflammatory markers, higher CRP, lower albumin and higher interleukin-8 were independent prognosticators. By combining these factors, a simple and accurate inflammatory index could be constructed.

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StephenW

循环炎性标记物为肝癌的系统评价
作者

    接受稿件在线：8月8日出版2016Full历史
    DOI：10.1111 / liv.13218View /保存引文
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抽象
背景与宗旨

许多循环炎性因子有牵连的肝细胞癌（HCC）的发病机理和预测。我们的目标是同时评估多个血清炎症因子的预测，并制定HCC客观的炎症评分。
方法

555例肝癌患者与配对血清样本前瞻性队列从2009年累计至2012年传统的炎症标志物的血药浓度，即C反应蛋白（CRP），白蛋白，中性粒细胞，淋巴细胞和血小板，测定和41等探索性标志物由多重法测定。该预测与标记的相互作用进行单因素和multivarite分析确定。
结果

队列被随机分为训练队列（N = 139）和验证组（N = 416）。有两个同伙之间的基线特征没有差异。在训练队列，整体生存的独立预后因素包括CRP [危险比（HR）1.107; p值= 0.003]，白蛋白（HR 0.953; P = 0.032）和白细胞介素-8（HR = 5.816; P <0.001）。我们已经通过增加血清IL-8水平修改现有的基于炎指数（IBI）。改性IBI可以患者分为四组具有不同的整体存活率（P <0.001）。该结果也证实在验证队列。当与IBI等常规炎症标志物相比，修改后的IBI有较好的预后性能更高的C指数和均匀性似然比卡方。
结论

当中传统和探索循环炎症标记物，CRP较高，低白蛋白和较高的白细胞介素-8是独立的预言。通过组合这些因素，一个简单而准确的炎症指标可以构造。