血清HBV核心相关抗原是在慢性乙型肝炎患者自发HBeAg血清学转

StephenW

J Med Virol. 2016 Aug 9. doi: 10.1002/jmv.24657. [Epub ahead of print]
Serum HBV core related antigen is a good predictor for spontaneous HBeAg seroconversion in chronic hepatitis B patients.Song G1, Yang R1, Rao H1, Feng B1, Ma H1, Jin Q1, Wei L1.
Author information

• 1Institutional affiliation: Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Peking University, Beijing, 100044, China.
  

AbstractEarly prediction of spontaneous hepatitis B virus e antigen (HBeAg) seroconversion is pivotal in the prevention of unnecessary drug prescription, corresponding financial burden and adverse reactions. One hundred and thirteen chronic hepatitis B patients with HBeAg-positive in the immune active phase were followed up for about one and half years. Patients were classified into two groups: spontaneous HBeAg seroconversion group (group A, n = 18) and non-spontaneous HBeAg seroconversion group. Among the non-spontaneous HBeAg seroconversion group, 35 patients were selected as controls (group B, n = 35). At week 12, there was a significant difference in hepatitis B core-related antigen (HBcrAg) levels between the two groups (group A 4.32 ± 1.05 log10 kU/mL, and group B 5.16 ± 0.53 log10 kU/mL, P = 0.004), and this significance magnified at week 28. Only two variables, HBcrAg level and the reduction in the HBcrAg levels (ΔHBcrAg) at week 28 were enrolled, with the odds ratio of 4.19 and 0.21, respectively. The optimal cutoffs of HBcrAg levels and the ΔHBcrAg at week 28 were 4.90 log10 kU/mL and 2.00 log10 kU/mL, respectively. The positive predictive value and negative predictive value of HBcrAg levels at week 28 were 73.9% and 96.7%, respectively. The positive predictive value and negative predictive value of the ΔHBcrAg at week 28 were 76.2% and 93.8%, respectively. The measurement of HBcrAg is useful for monitoring the natural course of chronic hepatitis B virus infection. The dynamics of HBcrAg levels could accurately predict the spontaneous HBeAg seroconversion. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.


KEYWORDS: hepatitis B; hepatitis B core-related antigen; natural history; prediction; spontaneous HBeAg seroconversion

PMID:27505145DOI:10.1002/jmv.24657

StephenW

医学杂志病毒学杂志。 2016年9月：10.1002 / jmv.24657。 [打印EPUB提前]
血清HBV核心相关抗原是在慢性乙型肝炎患者自发HBeAg血清学转换一个很好的预测。
宋G1，杨R1，饶H1，冯B1，马H1，​​金Q1，魏L1。
作者信息

    1Institutional单位：北京大学人民医院，北京大学肝病研究所，丙型肝炎和免疫治疗肝病，北京大学，北京，100044中国北京市重点实验室。

抽象

自发乙型肝炎病毒e抗原（HBeAg）血清转换的早期预测是防止不必要的药物处方的关键，相应的财政负担和不良反应。一百一十三慢性乙型肝炎患者的免疫活动期的HBeAg阳性约一年半随访。患者被分为两组：自发HBeAg血清学转换组（A组，n = 18）和非自发的HBeAg血清学转换组。在非自发的HBeAg血清学转换组，35例患者作为对照组（B组，n = 35）。在第12周时，两组间乙肝核心相关抗原（HBcrAg）水平显著差异（A组4.32±1.05日志10 KU /毫升，B组5.16±0.53日志10 KU /毫升，P = 0.004）和这个意义上在28.只有两个变量，HBcrAg一级和HBcrAg水平（ΔHBcrAg）在28周减少一周放大的患者，以分别4.19和0.21，比值比。 HBcrAg水平的最优截断，并在28周ΔHBcrAg为4.90 log10的KU / mL和2.00 log10的KU /毫升，。阳性预测值和28周HBcrAg水平阴性预测值分别为73.9％和96.7％。阳性预测值，并在28周ΔHBcrAg阴性预测值分别为76.2％和93.8％。 HBcrAg的测量是用于监测慢性乙肝病毒感染的自然过程是有用的。 HBcrAg水平的动态变化可以准确地预测自发的HBeAg血清学转换。本文由版权保护。版权所有。

本文由版权保护。版权所有。
关键词：

乙型肝炎;乙型肝炎核心相关抗原;自然历史;预测;自发的HBeAg血清学转换

结论：
    27505145
DOI：
    10.1002 / jmv.24657

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