红细胞分布宽度和球蛋白，在慢性肝炎患者肝纤维化和炎症

StephenW

    European Journal of Gastroenterology & Hepatology:   
    September 2016 - Volume 28 - Issue 9 - p 997–1002
            doi: 10.1097/MEG.0000000000000662
    Original Articles: Hepatitis
  
  Red blood cell distribution width and globulin, noninvasive indicators of fibrosis and inflammation in chronic hepatitis patients      

Wang, Huan; Xu, Hongqin; Qu, Limei; Wang, Xiaomei; Wu, Ruihong; Gao, Xiuzhu; Jin, Qinglong; Niu, Junqi

              
   
   
  
      [url=][/url]Abstract      
   
         

Aims: We aimed to develop new simple predictive models for significant fibrosis and inflammation in chronic hepatitis patients using routine laboratory parameters.

      

Methods: A total of 218 patients who had undergone liver biopsy were enrolled in our study. Among these, 116 had chronic hepatitis B, 65 had primary biliary cirrhosis, and 37 had autoimmune hepatitis. Patients were divided into two groups: absent–mild (S0–S1, G0–G1) and moderate–severe (S2–S4, G2–G4) according to the histologic severity of liver fibrosis and inflammation. All common demographics and routine laboratory parameters were analyzed.

      

Results: Red blood cell distribution width (RDW) and globulin values increased with progressive liver fibrosis and inflammation. After adjustment for other potent predictors, liver fibrosis was associated independently with RDW and platelet (odds ratio=0.976 and 1.487, respectively), whereas significant inflammation was associated independently with globulin, alanine aminotransferase, red blood cell, and platelet (odds ratio=1.153, 1.017, 0.392, and 1.487, respectively). The sensitivity and specificity of model A were 73.4 and 79.1% for the detection of significant liver fibrosis [area under the receiver-operating characteristic curve (AUROC)=0.81, P<0.001]. The sensitivity and specificity of model B were 75.9 and 88.9% for predicting advanced liver inflammation (AUROC=0.89, P<0.001). Compared with pre-existing indicators, model A achieved the highest AUROC (0.81, P<0.001) for liver fibrosis, whereas model B showed the highest AUROC (0.89, P<0.001) for liver inflammation.

      

Conclusion: RDW may provide a useful clinical value for predicting liver fibrosis; meanwhile, globulin may provide a useful clinical value for predicting liver inflammation in chronic hepatitis patients with other markers.

   
  

StephenW

欧洲胃肠病学杂志与肝病学：
2016年9月 - 28卷 - 第9 - P 997-1002
DOI：10.1097 / MEG.0000000000000662
原创文章：肝炎
红细胞分布宽度和球蛋白，在慢性肝炎患者肝纤维化和炎症的非侵入性的指标

王欢;徐，Hongqin;曲丽美;王小妹;吴，瑞虹;高，修竹;金，青龙;牛，军棋
折叠盒
抽象

目的：我们的目的是开发使用常规实验室参数的慢性肝炎患者肝纤维化显著和炎症新的简单的预测模型。

方法：共218例谁经历了肝活检在我们的研究对象。在这些中，116患有慢性乙型肝炎，65有原发性胆汁性肝硬化，和37具有自身免疫性肝炎。根据肝纤维化和炎症的组织学严重程度缺席温和（S0-S1，G0-G1）和重度（S2-S4，G2-G4）：患者被分为两组。所有常用的人口统计学和实验室常规参数进行了分析。

结果：红血细胞分布宽度（RDW）和球蛋白值与进行性肝纤维化和炎症增加。调整为其他有力的预测之后，肝纤维化，用RDW和血小板（比值比= 0.976和1.487，分别）独立地相关，而显著炎症与球蛋白，谷丙转氨酶，红细胞和血小板（比值比= 1.153独立相关，1.017，0.392，和1.487，分别）。灵敏度和模型A的特异性分别73.4和[接收者操作特性曲线（AUROC）= 0.81，p <0.001下面积]检测显著肝纤维化的79.1％。 B型的敏感性和特异性分别为75.9和预测晚期肝脏炎症（AUROC = 0.89，P <0.001）88.9％。与预先存在的指标相比，模型中的实现肝纤维化的AUROC最高（0.81，P <0.001），而B型表现出对肝脏炎症的最高AUROC（0.89，P <0.001）。

结论：RDW可以为预测肝纤维化一个有用的临床价值;与此同时，球蛋白可提供用于在慢性肝炎患者的其他标记物预测肝脏炎症的有益的临床价值。