减肥计划对血清谷丙转氨酶活性和肥胖乙肝患者免疫应答的

StephenW

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        Afr Health Sci. 2016 Mar;16(1):128-34. doi: 10.4314/ahs.v16i1.17.
Impact of weight reduction program on serum alanine aminotransferase activity and immunologic response in obese hepatitis B patients.Abd El-Kader SM1, Al-Dahr MH2.
Author information

• 1Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
• 2Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
  

AbstractBACKGROUND: Globally, chronic B viral hepatitis (HBV) is a major health problem. Obesity is a common problem among patients with HBV. Several studies have reported that obesity is an important risk factor that alters immune system response in individuals with no underlying cause of liver disease. However, there is a strong association between BMI and the human immune system among HBV patients.
OBJECTIVE: This study was to examine the correlation between body mass index, serum alanine aminotransferase activity (ALT) and immunologic response in obese hepatitis B patients.
MATERIAL AND METHODS: One hundred fifty male patients with chronic hepatitis B virus, their age ranged from 30 to 45 (38.64 ± 7.12) years and their BMI ranged from 30-35 kg/m(2). All Subjects were included in two groups: The first group received weight reduction program in the form of treadmill aerobic exercises in addition to diet control whereas the second group received no therapeutic intervention. Parameters of serum alanine aminotransferase (ALT), CD3, CD4 and CD8 were quantified; Leukocyte, differential counts and body mass index (BMI) were measured before and after 3 months at the end of the study.
RESULTS: There was a 24.7%, 36.8%, 30.8%, 40.7%, 28.6%, 25.9%, 33.3% and 14.3 % reduction in mean values of alanine aminotransferase (ALT), white blood cells, total neutrophil count, monocytes, CD3, CD4 , CD8 and BMI respectively in group (A) at the end of the study. In addition, there were significant differences between mean levels of the investigated parameters in groups.
CONCLUSION: Based on our findings, weight loss modulates serum alanine aminotransferase and immune system parameters of patients with hepatitis B virus infection.


KEYWORDS: Hepatitis B virus; immune system; obesity; weight reduction

PMID:27358623DOI:10.4314/ahs.v16i1.17

StephenW

发给
AFR健康科学。 2016年3月; 16（1）：128-34。 DOI：10.4314 / ahs.v16i1.17。
减肥计划对血清谷丙转氨酶活性和肥胖乙肝患者免疫应答的影响。
阿卜杜勒 - 卡德尔SM1，al-Dahr山MH2。
作者信息

    物理治疗中的应用医学科学院，阿卜杜勒阿齐兹国王大学，吉达，沙特阿拉伯教研室。
    医学检验技术，应用的医学科学学院，阿卜杜勒阿齐兹国王大学，吉达，沙特阿拉伯教研室。

抽象
背景：

全球范围内，慢性乙病毒性肝炎（HBV）是一个主要的健康问题。肥胖是例HBV中的共同问题。几个研究报导，肥胖是改变与肝病的没有潜在原因中的个体的免疫系统反应的重要危险因素。然而，存在的BMI和HBV患者中的人类免疫系统之间有很强的相关性。
目的：

这项研究是检查身体质量指数，血清谷丙转氨酶酶（ALT）和肥胖乙肝患者的免疫反应之间的相关性。
材料与方法：

一百五十男性慢性乙肝病毒，他们的年龄介于30至45（38.64±7.12）岁，他们的BMI从30-35公斤/米不等（2）。所有受试者被列入两组：第一组，而第二组没有收到任何治疗干预的除了饮食控制跑步机有氧运动的形式接收减重计划。血清谷丙转氨酶（ALT）的参数，CD3，CD4和CD8进行量化;白细胞，差分计数和身体质量指数（BMI）之前，并在研究结束后3个月分别测定。
结果：

有24.7％，36.8％，30.8％，40.7％，28.6％，25.9％，在丙氨酸转氨酶（ALT），白血细胞，总嗜中性粒细胞计数，单核细胞，CD3，CD4的平均值减少33.3％和14.3％ ，在研究结束时的CD8和BMI分别在组（A）。此外，还有在基所研究的参数的平均水平之间的显著差异。
结论：

根据我们的研究结果，减肥调节血清谷丙转氨酶和乙肝患者病毒感染的免疫系统参数。
关键词：

乙型肝炎病毒;免疫系统;肥胖;减重

结论：
    27358623
DOI：
    10.4314 / ahs.v16i1.17