[中国人群肝癌的疾病负担，1990年和2013年。

StephenW

Zhonghua Liu Xing Bing Xue Za Zhi. 2016 Jun 10;37(6):758-62. doi: 10.3760/cma.j.issn.0254-6450.2016.06.003.
[Disease burden of liver cancer in the Chinese population, in 1990 and 2013]. [Article in Chinese]
Wang LJ1, Yin P1, Liu YN1, Liu JM1, Qi JL1, Zhou MG2.
Author information

• 1Division of Vital Statistics and Death Surveillance, National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
• 2National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
  


AbstractOBJECTIVE: To analyze the disease burden of liver cancer in the Chinese population in 1990 and 2013.
METHODS: Data from Global Burden of Diseases 2013 (GBD2013) was used to analyze the disease burden of liver cancer in China. The main outcome measurements would include mortality and disability-adjusted life years (DALY). Again, GBD global standard population in 2013 was used as the reference population to calculate the age-standardized rate. Related changes on percentage from 1990 to 2013 were calculated to analyze the changing patterns of disease burden for liver cancer in China.
RESULTS: In 2013, a total of 358 100 people died of liver cancer, with the crude death rate as 25.85/100 000, in China. Number of deaths due to liver cancer secondary to hepatitis B was 163 600 (accounting for 45.69%). Number of deaths due to liver cancer secondary to hepatitis C was 134 200 (accounting for 37.48%) with DALY due to liver cancer appeared as 40.80 million person years. In 2013, the leading causes of DALY related to liver cancer was liver cancer secondary to hepatitis B, followed by liver cancer secondary to hepatitis C, liver cancer secondary to alcohol use, other liver cancers, with related DALYs as 4 652.0, 3 394.3, 964.3 and 592.1 thousands person years, respectively. The disease burdens of liver cancer secondary to various kinds of liver cancer were significantly higher in males than in females. Compared with 1990, the standardized mortality of liver cancer reduced by 25.00%, the DALY attributable to liver cancer increased by 16.95% and the standardized DALY rate attributable to liver cancer reduced by 33.47%. The burden of liver cancer secondary to hepatitis C became more serious and the standardized death rate increased by 106.18%, together with the standardized DALY rate increased by 91.68% in the past 23 years. Disease burden of liver cancer among young adults and the elderly were most serious. When comparing with the data in 1990, the standardized DALY rate showed declining trend in all the age groups, with the most seen in the 5-14 year group. The standardized DALY rate, secondary to hepatitis B had a 46.37% decrease in the 5-14 year olds. The standardized DALY rate secondary to hepatitis C showed an increasing trend in all the age groups.
CONCLUSIONS: Liver cancer had been one of the serious diseases that causing heavy disease burden in China. In recent years, the disease burden of liver cancer secondary to hepatitis B decreased but the disease burden of liver cancer secondary to hepatitis C significantly increased. Disease burden on liver cancer in male population was significantly higher than that in females, showing that related targeted prevention and control measures should be imminently carried out.


PMID:27346097 [PubMed - in process]  


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StephenW

中华刘星秉须鄂杂志。 2016年6月10日; 37（6）：758-62。 DOI：10.3760 / cma.j.issn.0254-6450.2016.06.003。
[中国人群肝癌的疾病负担，1990年和2013年。
[中国中文章]
王LJ1，尹P1，刘YN1，刘JM1，齐JL1，周MG2。
作者信息

    生命统计及死因监测，全国中心慢性非传染性疾病预防和控制，中国疾病预防控制中心，北京100050，中国的1区。
    2National中心慢性非传染性疾病预防和控制，中国疾病预防控制中心，北京100050，中国。

抽象
目的：

为了分析1990年和2013年肝癌在中国人群中的疾病负担。
方法：

从疾病的全球疾病负担2013（GBD2013）数据来分析肝癌在中国的疾病负担。主要结果的测量包括死亡率和伤残调整寿命年（DAL​​Y）。同样，在2013年GBD全球标准的人口作为参考人口计算年龄标准化率。计算上个2090至13年有关的变化来分析疾病负担模式的变化在中国肝癌。
结果：

在2013年，共有358 100人死于肝癌，与粗死亡率为25.85 / 10万，在中国。由于肝癌继发于B型肝炎的死亡人数为163 600（占45.69％）。由于肝癌继发丙型肝炎的死亡人数与DALY 134 200（占37.48％）由于肝癌表现为40.80亿人年。 2013年，达利与肝癌的主要原因是肝癌继发于B型肝炎，其次是肝癌继发于肝炎，肝癌继发于酒精的使用，其他肝脏肿瘤，与相关的伤残调整寿命为4 652.0 3 394.3， 964.3和592.1数千人年，分别为。继发于各种肝癌的肝癌的疾病负担均在男性比女性显著更高。与1990年相比，肝癌的标化死亡率由25.00％减少，DALY归属于肝癌上升了16.95％和标准化DALY率归因于肝癌由33.47％减少。肝癌继发丙型肝炎的负担变得更加严重，标准化死亡率上升了106.18％，与标准化DALY率在过去23年增长了91.68％在一起。青壮年肝癌的疾病负担和老人是最严重的。当与数据，1990年相比，标准化DALY率呈现在所有的年龄组出现下降趋势，最可见的5-14年的小组。标准化DALY率，继发乙肝曾在5-14岁的孩子一个46.37％的跌幅。标准化DALY率继发丙型肝炎显示，所有年龄组有增加的趋势。
结论：

肝癌一直是造成中国重的疾病负担严重的疾病之一。近年来，肝癌继发乙型肝炎疾病负担减少，但肝癌继发肝炎的疾病负担Ç显著增加。在男性人群肝癌疾病负担较显著高于女性，显示出相关的有针对性的预防和控制措施应迫切进行。

结论：
    27346097
    [考研 - 过程]