在乙肝病毒基因组的变化与肝癌的发展有关

StephenW

World J Gastroenterol. 2016 Jun 21;22(23):5393-9. doi: 10.3748/wjg.v22.i23.5393.
Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma.Lee D1, Lyu H1, Chung YH1, Kim JA1, Mathews P1, Jaffee E1, Zheng L1, Yu E1, Lee YJ1, Ryu SH1.
Author information

• 1Danbi Lee, Young-Hwa Chung, Jeong A Kim, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, South Korea.
  

AbstractAIM: To determine the genomic changes in hepatitis B virus (HBV) and evaluate their role in the development of hepatocellular carcinoma (HCC) in patients chronically infected with genotype C HBV.
METHODS: Two hundred and forty chronic hepatitis B (CHB) patients were subjected and followed for a median of 105 mo. HCC was diagnosed in accordance with AASLD guidelines. The whole X, S, basal core promoter (BCP), and precore regions of HBV were sequenced using the direct sequencing method.
RESULTS: All of the subjects were infected with genotype C HBV. Out of 240 CHB patients, 25 (10%) had C1653T and 33 (14%) had T1753V mutation in X region; 157 (65%) had A1762T/G1764A mutations in BCP region, 50 (21%) had G1896A mutation in precore region and 67 (28%) had pre-S deletions. HCC occurred in 6 patients (3%). The prevalence of T1753V mutation was significantly higher in patients who developed HCC than in those without HCC. The cumulative occurrence rates of HCC were 5% and 19% at 10 and 15 years, respectively, in patients with T1753V mutant, which were significantly higher than 1% and 1% in those with wild type HBV (P < 0.001).
CONCLUSION: The presence of T1753V mutation in HBV X-gene significantly increases the risk of HCC development in patients chronically infected with genotype C HBV.


KEYWORDS: Chronic hepatitis B; Genomic change; Genotype C; Hepatitis B virus; Hepatocellular carcinoma

StephenW

世界今日医学Gastroenterol。 2016年6月21日; 22（23）：5393-9。 DOI：10.3748 / wjg.v22.i23.5393。
在乙肝病毒基因组的变化与肝癌的发展有关。
李D1，吕H1，涌YH1，金JA1，马修斯P1，贾菲E1，郑L1，俞E1，李YJ1，刘某SH1。
作者信息

    1Danbi李，杨，华涌，郑某一金，内科，医学蔚山大学学院，峨山医院中心，首尔05505，韩系。

抽象
目标：

为了确定在乙型肝炎病毒（HBV）基因组的变化，并评估其在肝细胞癌（HCC）的发展慢性感染C型HBV患者的作用。
方法：

二百四十慢性乙型肝炎（CHB）的患者经受和随访105莫的中值。肝癌被确诊按照AASLD指南。使用直接测序法的整个X，S，基础核心启动子（BCP）和HBV前C区进行测序。
结果：

所有研究对象被感染C型HBV。出的240例CHB患者，25（10％）有C1653T和33（14％）在X区T1753V突变; 157（65％）在BCP区域A1762T / G1764A突变，50（21％）在前核心区和67（28％）G1896A突变有前S缺失。 HCC发生6例（3％）。 T1753V突变的发生率在谁开发HCC比那些没有HCC患者是显著高。肝癌的累积发生率分别为5％，并在10年和15年的19％，在患者T1753V突变体，均显著高于1％和在那些与野生型HBV（P <0.001）1％。
结论：

T1753V突变在HBV X基因的存在显著增加肝癌发展的慢性感染C型HBV患者的风险。
关键词：

慢性乙型肝炎;基因组的变化; C基因型;乙型肝炎病毒;肝细胞癌