25羟基维生素D水平与肝纤维化的关系在患者的评估由瞬时弹

StephenW

Gut Liver. 2016 Apr 28. doi: 10.5009/gnl15331. [Epub ahead of print]
Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease.Ko BJ1, Kim YS1, Kim SG1, Park JH1, Lee SH2, Jeong SW3, Jang JY3, Kim HS2, Kim BS1, Kim SM1, Kim YD4, Cheon GJ4, Lee BR5.
Author information

• 1Digestive Disease Center and Research Institute, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.
• 2Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.
• 3Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
• 4Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.
• 5Department of Biostatistical Consulting, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
  

AbstractBackground/Aims: Deficiencies of 25-hydroxyvitamin D (25(OH)D) are prevalent in patients with chronic liver disease (CLD). Liver fibrosis is the main determinant of CLD prognosis. The present study was performed to evaluate the correlation between 25(OH)D levels and liver fibrosis as assessed by transient elastography (TE) in patients with compensated CLD.
Methods: Serum 25(OH)D levels and liver stiffness were determined in a total of 207 patients who were subjected to the following exclusion criteria patients with decompensated CLD; patients who had malignancies; patients who were taking medications; and patients who were pregnant.
Results: The most common etiology was chronic hepatitis B (53.1%). Advanced liver fibrosis (defined by TE [≥9.5 kPa]) was present in 75 patients (36.2%). There was a significant correlation between 25(OH)D deficiency and liver stiffness. Based on the multivariate analysis, the following factors were independently associated with advanced liver fibrosis 25(OH)D deficiency (odds ratio [OR], 3.46; p=0.004), diabetes mellitus (OR, 3.04; p=0.041), and fibrosis-4 index (OR, 2.01; p<0.001).
Conclusions: Patients with compensated CLD exhibit a close correlation between vitamin D level and liver stiffness as assessed by TE. Vitamin D deficiency was independently associated with advanced liver fibrosis.


KEYWORDS: 25-Hydroxyvitamin D deficiency; Liver stiffness; Transient elastography

StephenW

肠肝。 2016年四月28 DOI：10.5009 / gnl15331。 [打印EPUB提前]
25羟基维生素D水平与肝纤维化的关系在患者的评估由瞬时弹性慢性肝病。
柯BJ1，金YS1，金SG1，公园JH1，SH2李某，郑某SW3，张JY3，金HS2，金BS1，金SM1，金YD4，千GJ4，李BR5。
作者信息1消化疾病中心研究所，内科，顺天乡大学富川医院，医药，富川，韩国的顺天乡大学。内科，顺​​天乡大学天安医院，中医药大学顺天乡大学，天安，韩国教研室。内科，顺​​天乡大学首尔医院，中医药大学顺天乡大学，韩国首尔的3Department。内科，江陵峨山医院，中医药大学蔚山大学，江陵，韩国4Department。生物统计学咨询，顺天乡大学富川医院，富川，韩国5Department。
抽象
背景/目的：
25-羟维生素D（25（OH）D）的不足之处是在慢性肝病（CLD）普遍。肝纤维化是CLD预后的主要决定因素。进行本研究通过患者的补偿的CLD瞬时弹性（TE）作为评估25（OH）D水平和肝纤维化的评价的相关性。
方法：
血清25（OH）D水平与肝脏硬度在总共谁，进行了以下的排除标准失代偿CLD 207名患者进行了测定;例谁恶性肿瘤;谁是服用药物的患者;和病人谁是怀孕了。
结果：
最常见的病因是慢性乙型肝炎（53.1％）。晚期肝纤维化（由TE [≥9.5千帕]中定义）存在于75例（36.2％）。有25（OH）D缺乏和肝脏硬度之间有显著的相关性。 ，糖尿病（OR，3.04; P = 0.041）和纤维化;根据多变量分析，以下因素是独立拥有先进的肝纤维化25（OH）D缺乏（P = 0.004比值比[OR]，3.46）相关-4指数（OR，2.01; p <0.001）。
结论：
例代偿CLD展览所评估的TE维生素D水平与肝脏硬度密切相关。维生素D缺乏独立与先进的肝纤维化。
关键词：
25-羟基维生素D缺乏症;肝脏硬度;瞬时弹性