15/10/02说明:此前论坛服务器频繁出错,现已更换服务器。今后论坛继续数据库备份,不备份上传附件。

肝胆相照论坛

 

 

肝胆相照论坛 论坛 学术讨论& HBV English Altimmune扩大临床开发团队
查看: 1623|回复: 5
go

Altimmune扩大临床开发团队 [复制链接]

Rank: 8Rank: 8

现金
62111 元 
精华
26 
帖子
30437 
注册时间
2009-10-5 
最后登录
2022-12-28 

才高八斗

1
发表于 2016-4-6 11:41 |只看该作者 |倒序浏览 |打印
Altimmune Expands Clinical Development Team
Print
April 05, 2016 08:30 ET | Source: Altimmune, Inc.

Appoints Sybil Tasker as Senior Vice President, Clinical Research and Development

Names Efe Egharevba as Head of Clinical Project Management

GAITHERSBURG, Md., April 05, 2016 (GLOBE NEWSWIRE) -- Altimmune, Inc., a clinical stage immunotherapeutic company, today announced the expansion of its clinical development team. Sybil Tasker, M.D., FACP, FIDSA, was appointed as Senior Vice President, Clinical Research and Development. Dr. Tasker will be responsible for overseeing Altimmune’s clinical research and development programs. Efe Egharevba was named Head of Clinical Project Management.  He will be responsible for overseeing the ongoing Phase 1 trial of HepTcell in the treatment of chronic hepatitis B (CHB) patients.

Bill Enright, President and Chief Executive Officer of Altimmune, remarked, “We are excited to welcome Dr. Tasker and Mr. Egharevba to our team. Dr. Tasker has an impressive background in global clinical development through Phase 3 and post-marketing studies including vaccines and antivirals. She is well positioned to be a key member of the development efforts of the three clinical programs Altimmune expects to run over the course of 2016. Dr. Tasker will play a key role as we move our NasoVAX™ influenza vaccine candidate into a Phase II trial later this year, begin enrollment of our planned Phase I trial for our NasoShield™ anthrax vaccine candidate, and manage enrollment of our ongoing Phase I trial of HepTcell for the treatment of Chronic Hepatitis B.”

“I am thrilled to join Altimmune at this juncture in the Company’s development. 2016 will be a pivotal year for Altimmune with a number of upcoming clinical milestones and data readouts. Altimmune’s products have already demonstrated their exciting potential and are well poised to move quickly toward Phase 3.  The two unique technology platforms are incredibly complementary, giving us the flexibility to drive the optimal immune response in a wide array of disease indications,” said Dr. Tasker.

Dr. Tasker joins Altimmune from Genocea Biosceiences, where she was a Senior Director of Clinical Development and led the GEN-003 therapeutic vaccine program. Previously a career military officer, Dr. Tasker held senior leadership roles involving pandemic influenza and biodefense planning within the Department of Defense, in addition to patient care and clinical research activities. Following that, she guided infectious disease therapeutic area clinical development strategy at two leading global CROs, involving a wide variety of sponsors and indications, including two successful BARDA proposals for influenza vaccines and multiple pivotal phase 3 programs for antimicrobials that are currently on the market. Dr. Tasker received an A.B. in Biochemistry from Princeton University and an M.D. from Columbia University.

Mr. Egharevba has 12 years of clinical trial experience in a variety of disease indications including oncology, cardiovascular disease and rheumatology. He joins Altimmune from Takeda, and has held prior positions at Roche, Amgen, and Genmab. Mr. Egharevba received a B.S. in Biology from the University of North Texas and a Masters Degree in Clinical Research from Cardiff University.

About Altimmune
Altimmune is a clinical stage immunotherapeutic company focused on the development of products to stimulate robust and durable immune responses for the prevention and treatment of disease. The Company has two proprietary platform technologies, RespirVec and Densigen, each of which has been shown to activate the immune system in distinctly different ways than traditional vaccines. Using these technologies, Altimmune has developed three novel clinical stage product candidates that potentially represent an entirely new approach to harnessing the immune system.

The Company’s most advanced product candidate, NasoVAX, is a Phase 2-ready intranasally-delivered recombinant influenza vaccine offering broad and rapid protection with potential for significant advantages over traditional flu vaccines. The second most advanced product candidate, HepTcell, is currently being tested in a Phase 1 clinical study as an immunotherapy for patients chronically infected with hepatitis B and has the potential to provide a functional cure. With the support of the U.S. Biomedical Advanced Research and Development Authority, or BARDA, the Company is developing a third product candidate, NasoShield, a first-in-class anthrax vaccine designed to provide rapid, stable protection after one intranasal administration. The Company intends to leverage the RespirVec and Densigen platforms to develop additional product candidates for a variety of indications.

CONTACT: Altimmune Contacts

Bill Enright
President and CEO
Phone: 240-654-1450
Email: [email protected]

Investor Relations
Stephanie Carrington
ICR, Inc.
Phone: 646-277-1282
Email: [email protected]

Rank: 8Rank: 8

现金
62111 元 
精华
26 
帖子
30437 
注册时间
2009-10-5 
最后登录
2022-12-28 

才高八斗

2
发表于 2016-4-6 11:42 |只看该作者
Altimmune扩大临床开发团队
打印
2016年4月5日08:30 ET |来源:Altimmune公司

任命西比尔塔斯克担任高级副总裁,临床研究与发展

埃菲名称作为Egharevba临床项目管理负责人

。马里兰州盖瑟斯堡,2016年4月5日(GLOBE NEWSWIRE) - Altimmune公司是一家临床分期免疫治疗公司,今天宣布其临床开发团队的扩充。西比尔塔斯克,医学博士,FACP,FIDSA,被任命为高级副总裁,临床研究与发展。塔斯克博士将负责监督Altimmune的临床研究和发展计划。埃菲社Egharevba被命名为临床项目管理负责人。他将负责监督HepTcell正在进行的第一阶段试验在慢性乙型肝炎(CHB)患者的治疗。

比尔恩莱特,总裁Altimmune的首席执行官说,“我们非常高兴地欢迎塔斯克博士和Egharevba先生加入我们的团队。塔斯克博士通过第3阶段和上市后研究,包括疫苗和抗病毒药物的全球临床开发一个令人印象深刻的背景。她具备成为三个临床项目的发展努力Altimmune预计2016年超过塔斯克博士的过程中运行将起到关键的作用,因为我们把我们的NasoVAX™流感候选疫苗进入二期临床试验的主要成员今年晚些时候,我们开始计划I期临床试验为我们NasoShield™炭疽疫苗候选招生,并为慢性乙型肝炎的治疗管理我们HepTcell正在进行I期临床试验的招生“

“我很高兴在这个时刻在公司发展加盟Altimmune。 2016年将是Altimmune的关键一年与一些即将到来的临床里程碑和数据读出的。 Altimmune的产品已经展现了自己令人兴奋的潜力,并作好准备,以快速向着第三阶段的两个独特的技术平台是令人难以置信的互补性,使我们能够灵活地推动了广泛的疾病适应症的最佳免疫反应动,“博士说:塔斯克。

塔斯克博士Genocea Biosceiences,在那里她是临床发展的高级总监,并带领GEN-003治疗性疫苗的程序加入Altimmune。以前是职业军官,塔斯克博士举行涉及国防部内的流感大流行和生物防御计划,除了病人护理和临床研究活动的高级领导职务。随后,她引导感染性疾病治疗领域的临床发展战略的两个全球领先的CRO公司,涉及各种各样的赞助商和适应症,其中包括两次成功巴尔达建议流感疫苗和多个关键的第三阶段方案是目前市场上的抗菌剂。塔斯克博士获得的高级水手生物化学普林斯顿大学和哥伦比亚大学的医学博士学位。

Egharevba先生拥有12年的各种疾病适应症包括肿瘤,心血管疾病和风湿病的临床试验经验。他加入Altimmune武田,并曾在罗氏,安进和Genmab公司之前的位置。 Egharevba先生获得了学士学位从北德克萨斯卡迪夫大学的大学和硕士学位临床研究生物学。

关于Altimmune
Altimmune是一家临床阶段的免疫治疗公司专注于产品,以刺激预防和治疗疾病的坚固耐用的免疫应答的发展。公司有两个专有平台技术,RespirVec和Densigen,其每一个已显示激活免疫系统在比传统疫苗明显不同的方式。使用这些技术,Altimmune制订了三个新的临床阶段的候选产品的潜在代表一种全新的方法来利用免疫系统。

该公司的最先进的产品候选人,NasoVAX,是第2阶段准备鼻内交付重组流感疫苗提供了潜在的广泛和快速的保护比传统的流感疫苗显著的优势。第二个最先进产品候选人,HepTcell,目前正在以第1阶段临床研究中测试为慢性感染乙型肝炎患者的免疫治疗,并具有提供一种功能治愈的可能性。与之相配套的美国生物医学高级研究与发展管理局或巴尔达的,该公司正在开发第三个候选产品,NasoShield,创一流的炭疽疫苗设计了一个鼻腔给药后提供快速,稳定的保护。本公司拟利用RespirVec和Densigen平台开发更多的产品候选人为各种适应症。

联系方式:联系人Altimmune

比尔恩莱特
总裁兼首席执行官
电话:240-654-1450
电子邮件:enright@alt​​immune.com

投资者关系
斯蒂芬妮卡林顿
ICR公司
电话:646-277-1282
电子邮件:[email protected]

Rank: 9Rank: 9Rank: 9

现金
17064 元 
精华
12 
帖子
9399 
注册时间
2007-6-26 
最后登录
2017-11-25 

风雨同舟

3
发表于 2016-4-6 18:39 |只看该作者
为什么今年来治愈乙肝的药物这么多?因为核苷类药物的价值已经被榨干。
日行一善(百善孝为先)

Rank: 6Rank: 6

现金
1032 元 
精华
帖子
664 
注册时间
2001-12-16 
最后登录
2022-2-9 
4
发表于 2016-4-6 18:54 |只看该作者
希望治疗乙肝药物到达功能性治愈的时代!

Rank: 10Rank: 10Rank: 10

现金
14967 元 
精华
帖子
8594 
注册时间
2008-4-12 
最后登录
2024-11-3 
5
发表于 2016-4-6 20:17 |只看该作者
治疗疫苗?
欢迎收看肝胆卫士大型生活服务类节目《乙肝勿扰》,我们的目标是:普度众友,收获幸福。
我是忠肝义胆MP4。忠肝义胆-战友的天地
QQ群搜"忠肝义胆孰能群"加入

Rank: 8Rank: 8

现金
62111 元 
精华
26 
帖子
30437 
注册时间
2009-10-5 
最后登录
2022-12-28 

才高八斗

6
发表于 2016-4-6 21:24 |只看该作者
MP4 发表于 2016-4-6 20:17
治疗疫苗?

Yes.

HepTcell is a peptide-based immunotherapeutic incorporating Vaxin’s proprietary
Densigen™ technology. This product candidate comprises nine long peptides covering conserved regions of core, polymerase  and surface proteins  from  HBV,  each  linked  to  a  fluorocarbon tail which  acts  to enhance immune  responses.  Using  a bioinformatics platform, HepTcell has been designed to elicit T cell responses to each of the major infecting HBV genotypes,  as  well  as
in an  ethnically  diverse  population,  thereby  allowing  applicability  across  a  world
-wide market.
Treatment with HepTcell aims to restore functional T cell immune responses to the hepatitis virus in HBV-infected subjects where the natural immune responses are lacking or poor.

是。

HepTcell是集Vaxin专有的基于肽基免疫治疗
Densigen™技术。此产品候选人包括九名长肽覆盖从HBV核心,聚合酶和表面蛋白质中,每个连接到一个氟碳尾巴,其作用以增强免疫应答的保守区。使用生物信息学平台,HepTcell已被设计为引起T细胞应答对每个主要感染HBV基因型的,以及
在一个种族多元化的人口,从而使整个世界的适用性
- 宽市场。
与HepTcell治疗的目的自然免疫反应缺乏或较差的地方恢复到肝炎病毒乙肝病毒感染者的功能性T细胞的免疫应答。
已有 1 人评分现金 收起 理由
MP4 + 1

总评分: 现金 + 1   查看全部评分

‹ 上一主题|下一主题
你需要登录后才可以回帖 登录 | 注册

肝胆相照论坛

GMT+8, 2024-11-5 13:39 , Processed in 0.014622 second(s), 12 queries , Gzip On.

Powered by Discuz! X1.5

© 2001-2010 Comsenz Inc.